ENSMUSG00000023802


Mus musculus

Features
Gene ID: ENSMUSG00000023802
  
Biological name :Nox3
  
Synonyms : NADPH oxidase 3 / Nox3 / Q672J9
  
Possible biological names infered from orthology : Q9HBY0
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A1
Gene start: 3635240
Gene end: 3696261
  
Corresponding Affymetrix probe sets: 10447530 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000111466
NCBI entrez gene - 224480     See in Manteia.
MGI - MGI:2681162
RefSeq - NM_198958
RefSeq Peptide - NP_945196
swissprot - Q672J9
Ensembl - ENSMUSG00000023802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOX3ENSGALG00000013659Gallus gallus
 NOX3ENSG00000074771Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*ENSMUSG0000001534057
Nox1 / Q8CIZ9 / NADPH oxidase 1 / Q9Y5S8*ENSMUSG0000003125752
Nox4 / Q9JHI8 / NADPH oxidase 4 / Q9NPH5*ENSMUSG0000003056236
Duox1 / dual oxidase 1 / Q9NRD9*ENSMUSG0000003326829
Duox2 / dual oxidase 2 / Q9NRD8*ENSMUSG0000006845228


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029653  NADPH oxidase 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0009590 detection of gravity IMP
 biological_processGO:0009629 response to gravity IMP
 biological_processGO:0042554 superoxide anion generation IDA
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha,Grip2tm1Rha/Grip2tm1Rha
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tigittm1Sdl/Tigittm1Sdl,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha,Grip2tm1Rha/Grip2tm1Rha
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha,Grip2tm1Rha/Grip2tm1Rha
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

Allelic Composition: Nox3het-R542/Nox3het-R542
Genetic Background: C3HeB/FeJ-Nox3het-R542

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Tigittm1Sdl/Tigittm1Sdl,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6

 MP:0001443 poor grooming "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404]
Show

Allelic Composition: Tigittm1Sdl/Tigittm1Sdl,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha,Grip2tm1Rha/Grip2tm1Rha
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

Allelic Composition: Nox3het-3J/Nox3het-3J
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

Allelic Composition: Nox3het-R542/Nox3het-R542
Genetic Background: C3HeB/FeJ-Nox3het-R542

Allelic Composition: Nox3het-2J/Nox3het-2J
Genetic Background: B10.Q-H2q/SgJ

Allelic Composition: Nox3het-5J/Nox3het-5J
Genetic Background: CByJ.Cg-Nox3het-5J/GrsrJ

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

Allelic Composition: Nox3het-R542/Nox3het-R542
Genetic Background: C3HeB/FeJ-Nox3het-R542

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

 MP:0002978 absent otoliths "absence of the crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

Allelic Composition: Nox3het-3J/Nox3het-3J
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

Allelic Composition: Nox3het-R542/Nox3het-R542
Genetic Background: C3HeB/FeJ-Nox3het-R542

Allelic Composition: Nox3het-2J/Nox3het-2J
Genetic Background: B10.Q-H2q/SgJ

Allelic Composition: Nox3het-5J/Nox3het-5J
Genetic Background: CByJ.Cg-Nox3het-5J/GrsrJ

 MP:0002980 abnormal postural reflex "failure to respond with the normal extension of legs to maintain balance when the cage is tilted" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88306]
Show

Allelic Composition: Nox3het-3J/Nox3het-3J
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

Allelic Composition: Nox3het-R542/Nox3het-R542
Genetic Background: C3HeB/FeJ-Nox3het-R542

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

 MP:0004845 absent vestibuloocular reflex "absence of nystagmus or deviation of the eyes in response to stimulation of the vestibular system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha,Grip2tm1Rha/Grip2tm1Rha
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

Allelic Composition: Nox3het-3J/Nox3het-3J
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Nox3het-R96/Nox3het-R96
Genetic Background: C3HeB/FeJ-Nox3het-R96

Allelic Composition: Nox3het-R542/Nox3het-R542
Genetic Background: C3HeB/FeJ-Nox3het-R542

Allelic Composition: Nox3het-2J/Nox3het-2J
Genetic Background: B10.Q-H2q/SgJ

Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J

Allelic Composition: Nox3het/Nox3het,T31H/T+
Genetic Background: involves: 101/H * C3H/HeH * TFH

Allelic Composition: Nox3het/Nox3het,T33H/T+
Genetic Background: involves: 101/H * C3H/HeH * TFH

Allelic Composition: Nox3het/Nox3het,T36H/T+
Genetic Background: involves: 101/H * C3H/HeH * TFH

Allelic Composition: Nox3het-5J/Nox3het-5J
Genetic Background: CByJ.Cg-Nox3het-5J/GrsrJ

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nox3het-5J/Nox3het-5J
Genetic Background: CByJ.Cg-Nox3het-5J/GrsrJ

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Nox3het/Nox3het
Genetic Background: B6Ei.GL-Nox3het/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006519 Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSMUSG00000026480 Ncf2 / O70145 / Neutrophil cytosol factor 2 / P19878* / neutrophil cytosolic factor 2*  / complex
 ENSMUSG00000036805 Noxa1 / Q8CJ00 / NADPH oxidase activator 1 / Q86UR1*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000015950 Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr