| MP:0000260 | abnormal angiogenesis | "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
|
| MP:0000343 | altered response to myocardial infarction | "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
|
| MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
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Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
|
| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
|
| MP:0001473 | reduced long term potentiation | "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0001731 | abnormal postnatal growth | "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0001845 | abnormal inflammatory response | "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0002133 | abnormal respiratory system physiology | "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0002284 | abnormal tracheal smooth muscle morphology | "structural anomaly of the smooth muscle lining the trachea" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0002406 | increased susceptibility to infection | "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0002410 | decreased susceptibility to viral infection | "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd
|
| MP:0002451 | abnormal macrophage physiology | "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd
|
| MP:0002463 | abnormal neutrophil physiology | "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
|
| MP:0002500 | granulomatous inflammation | "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0002842 | increased blood pressure | "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0002928 | abnormal bile duct morphology | "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
|
| MP:0002972 | abnormal cardiac muscle contractility | "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
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| MP:0003008 | enhanced long term potentiation | "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
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| MP:0003026 | decreased vascular smooth muscle contraction | "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0003184 | increased ACE activity | |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0003313 | abnormal locomotor activation | "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
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| MP:0003332 | liver abscess | "collection of purulent exudate within the liver as a result of infection by bacteria, protozoa, or other agents " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
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| MP:0003352 | increased circulating renin level | "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
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| MP:0003449 | abnormal intestinal goblet cells | "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282] |
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Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0003561 | rheumatoid arthritis | "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp2tm10Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
|
| MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
|
| MP:0003724 | susceptibility to induced arthritis | "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Mesp2tm10Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0004003 | abnormal vascular endothelial cell physiology | "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
|
| MP:0004799 | increased susceptibility to experimental autoimmune encephalomyelitis | "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp2tm10Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
|
| MP:0004800 | decreased susceptibility to experimental autoimmune encephalomyelitis | "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp2tm10Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0004883 | abnormal blood vessel healing | "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
|
| MP:0005025 | response to infection | "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0005074 | defective granulocyte bactericidal activity | "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5405] |
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Allelic Composition: Lrp6Cd/Lrp6Cd
Genetic Background: A-Lrp6Cd
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| MP:0005087 | reduced acute inflammation | "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478] |
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Allelic Composition: F2rtm1.1Cgh/F2rtm1.1Cgh,F2rl1tm2Cgh/F2rl1tm2Cgh,Tg(Tek-F2r)1Cgh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005088 | increased acute inflammation | "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0005340 | altered susceptibility to atherosclerosis | "a change in the likelihood that an organism will develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0005595 | abnormal vascular smooth muscle physiology | "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
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| MP:0005617 | increased susceptibility to type IV hypersensitivity reaction | "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mesp2tm10Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0006264 | decreased systolic blood pressure | "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0006278 | aortic aneurysm | "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0009456 | impaired cued conditioning behavior | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
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| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0009868 | abnormal descending thoracic aorta morphology | "any structural anomaly of the part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" [http://www.medterms.com "MedicineNet.com"] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0010895 | increased lung compliance | "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
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| MP:0010936 | decreased airway resistance | "reduced opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith] |
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Allelic Composition: Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: B6.129S2-Ncf1tm1Shl
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