ENSGALG00000001189


Gallus gallus

Features
Gene ID: ENSGALG00000001189
  
Biological name :NCF1
  
Synonyms : NCF1 / neutrophil cytosol factor 1
  
Possible biological names infered from orthology : neutrophil cytosolic factor 1 / P14598 / Q09014
  
Species: Gallus gallus
  
Chr. number: 19
Strand: -1
Band:
Gene start: 2625770
Gene end: 2632588
  
Corresponding Affymetrix probe sets: GgaAffx.11658.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000034504
NCBI entrez gene - 417485     See in Manteia.
RefSeq - NM_001030709
RefSeq - XM_015295704
RefSeq Peptide - NP_001025880
swissprot - F1NW14
Ensembl - ENSGALG00000001189
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncf1ENSDARG00000033735Danio rerio
 NCF1ENSG00000158517Homo sapiens
 Ncf1ENSMUSG00000015950Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SH3PXD2A / SH3 and PX domains 2A / O89032* / Q5TCZ1* / SH3 and PX domain-containing protein 2A *ENSGALG0000000829332
SH3PXD2B / SH3 and PX domains 2B / A1X283* / A2AAY5* / SH3 and PX domain-containing protein 2B *ENSGALG0000000283130
NOXO1 / NADPH oxidase organizer 1 / Q8NFA2* / Q8VCM2*ENSGALG0000000557228


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001655  Neutrophil cytosol factor 1
 IPR001683  Phox homologous domain
 IPR015039  NADPH oxidase subunit p47Phox, C-terminal
 IPR032136  Neutrophil cytosol factor 1, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006612 protein targeting to membrane IEA
 biological_processGO:0006801 superoxide metabolic process IBA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0055114 oxidation-reduction process IBA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071800 podosome assembly IBA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 cellular_componentGO:0002102 podosome IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IBA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IBA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr