ENSDARG00000033735


Danio rerio

Features
Gene ID: ENSDARG00000033735
  
Biological name :ncf1
  
Synonyms : ncf1 / neutrophil cytosolic factor 1
  
Possible biological names infered from orthology : Neutrophil cytosol factor 1 / P14598 / Q09014
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 61432541
Gene end: 61445697
  
Corresponding Affymetrix probe sets: Dr.2973.1.A1_at (Zebrafish Array)   NM_001030071_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000050897
NCBI entrez gene - 378966     See in Manteia.
RefSeq - NM_001030071
RefSeq Peptide - NP_001025242
swissprot - A2BFP2
ZFIN ID - ZDB-GENE-031006-6
Ensembl - ENSDARG00000033735
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCF1ENSGALG00000001189Gallus gallus
 NCF1ENSG00000158517Homo sapiens
 Ncf1ENSMUSG00000015950Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sh3pxd2b / SH3 and PX domains 2B / A1X283* / A2AAY5* / SH3 and PX domain-containing protein 2B *ENSDARG0000010325130
noxo1a / NADPH oxidase organizer 1a / NOXO1* / Q8NFA2* / NADPH oxidase organizer 1*ENSDARG0000004129425
sh3pxd2aa / SH3 and PX domains 2Aa / Q5TCZ1* / O89032* / SH3PXD2A* / SH3 and PX domains 2A* / SH3 and PX domain-containing protein 2A *ENSDARG0000006014824
noxo1b / NADPH oxidase organizer 1b / NOXO1* / Q8NFA2* / Q8VCM2* / NADPH oxidase organizer 1*ENSDARG0000005637424
sh3pxd2ab / SH3 and PX domains 2Ab / Q5TCZ1* / O89032* / SH3PXD2A* / SH3 and PX domains 2A* / SH3 and PX domain-containing protein 2A *ENSDARG0000006175819


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001655  Neutrophil cytosol factor 1
 IPR001683  Phox homologous domain
 IPR015039  NADPH oxidase subunit p47Phox, C-terminal
 IPR032136  Neutrophil cytosol factor 1, C-terminal
 IPR034909  Neutrophil cytosol factor 1, PX domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045730 respiratory burst IMP
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:0055114 oxidation-reduction process IBA
 biological_processGO:0071800 podosome assembly IBA
 cellular_componentGO:0002102 podosome IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IBA
 molecular_functionGO:0035091 phosphatidylinositol binding IBA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism dead , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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