ENSDARG00000060148


Danio rerio

Features
Gene ID: ENSDARG00000060148
  
Biological name :sh3pxd2aa
  
Synonyms : SH3 and PX domains 2Aa / sh3pxd2aa
  
Possible biological names infered from orthology : O89032 / Q5TCZ1 / SH3 and PX domain-containing protein 2A / SH3 and PX domains 2A / SH3PXD2A
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 47585700
Gene end: 47686888
  
Corresponding Affymetrix probe sets: Dr.23092.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000078892
Ensembl peptide - ENSDARP00000127586
NCBI entrez gene - 562018     See in Manteia.
RefSeq - NM_001160022
RefSeq Peptide - NP_001153494
swissprot - T1ECT1
swissprot - X1WBJ5
ZFIN ID - ZDB-GENE-060503-271
Ensembl - ENSDARG00000060148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SH3PXD2AENSGALG00000008293Gallus gallus
 Q5TCZ1ENSG00000107957Homo sapiens
 O89032ENSMUSG00000053617Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sh3pxd2ab / SH3 and PX domains 2Ab / Q5TCZ1* / O89032* / SH3PXD2A* / SH3 and PX domains 2A* / SH3 and PX domain-containing protein 2A *ENSDARG0000006175837
sh3pxd2b / SH3 and PX domains 2B / A1X283* / A2AAY5* / SH3 and PX domain-containing protein 2B *ENSDARG0000010325128
noxo1a / NADPH oxidase organizer 1a / NOXO1* / Q8NFA2* / NADPH oxidase organizer 1*ENSDARG000000412949
ncf1 / neutrophil cytosolic factor 1 / P14598* / Q09014* / Neutrophil cytosol factor 1 *ENSDARG000000337359
noxo1b / NADPH oxidase organizer 1b / NOXO1* / Q8NFA2* / Q8VCM2* / NADPH oxidase organizer 1*ENSDARG000000563748


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001655  Neutrophil cytosol factor 1
 IPR001683  Phox homologous domain
 IPR034917  SH3 and PX domain-containing protein 2A
 IPR035449  SH3PXD2A, SH3 domain 3
 IPR035450  SH3PXD2A, SH3 domain 1
 IPR035452  SH3PXD2A, SH3 domain 2
 IPR035453  SH3PXD2A, SH3 domain 4
 IPR035454  SH3PXD2A, SH3 domain 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Invadopodia formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001115 trunk trunk melanocyte decreased amount , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage absent , abnormal
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 ZFA:0001338 intestine intestine morphology , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
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 ZFA:0009004 trunk neural crest cell trunk neural crest cell morphology , abnormal
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 ZFA:0009165 neural crest cell neural crest cell increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000067545 adam19b / ADAM metallopeptidase domain 19b / ADAM19* / O35674* / Q9H013* / ADAM metallopeptidase domain 19* / Disintegrin and metalloproteinase domain-containing protein 19 *  / reaction / complex
 ENSDARG00000089213 adam15 / ADAM metallopeptidase domain 15 / O88839* / Q13444* / Disintegrin and metalloproteinase domain-containing protein 15 *  / reaction / complex






 

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