ENSG00000107957


Homo sapiens

Features
Gene ID: ENSG00000107957
  
Biological name :SH3PXD2A
  
Synonyms : Q5TCZ1 / SH3 and PX domains 2A / SH3PXD2A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.33
Gene start: 103594027
Gene end: 103855543
  
Corresponding Affymetrix probe sets: 207661_s_at (Human Genome U133 Plus 2.0 Array)   213252_at (Human Genome U133 Plus 2.0 Array)   224817_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000348215
Ensembl peptide - ENSP00000358789
Ensembl peptide - ENSP00000395781
NCBI entrez gene - 9644     See in Manteia.
RefSeq - XM_017016970
RefSeq - NM_014631
RefSeq - XM_006718080
RefSeq - XM_011540385
RefSeq - XM_017016969
RefSeq - XM_005270294
RefSeq - XM_005270295
RefSeq - XM_005270298
RefSeq - XM_006718079
RefSeq Peptide - NP_055446
swissprot - Q5TCZ1
swissprot - H0Y507
Ensembl - ENSG00000107957
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh3pxd2aaENSDARG00000060148Danio rerio
 sh3pxd2abENSDARG00000061758Danio rerio
 SH3PXD2AENSGALG00000008293Gallus gallus
 O89032ENSMUSG00000053617Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A1X283 / SH3PXD2B / SH3 and PX domains 2BENSG0000017470535
NCF1 / P14598 / neutrophil cytosolic factor 1ENSG0000015851712
NOXO1 / Q8NFA2 / NADPH oxidase organizer 1ENSG000001964087


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001683  Phox homologous domain
 IPR034917  SH3 and PX domain-containing protein 2A
 IPR035449  SH3PXD2A, SH3 domain 3
 IPR035450  SH3PXD2A, SH3 domain 1
 IPR035452  SH3PXD2A, SH3 domain 2
 IPR035453  SH3PXD2A, SH3 domain 4
 IPR035454  SH3PXD2A, SH3 domain 5
 IPR036028  SH3-like domain superfamily
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IMP
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0055114 oxidation-reduction process IBA
 biological_processGO:0071800 podosome assembly IBA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0072675 osteoclast fusion IMP
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IBA
 molecular_functionGO:0035091 phosphatidylinositol binding IBA


Pathways (from Reactome)
Pathway description
Invadopodia formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135074 ADAM19 / Q9H013 / ADAM metallopeptidase domain 19  / reaction / complex
 ENSG00000143537 ADAM15 / Q13444 / ADAM metallopeptidase domain 15  / complex / reaction
 ENSG00000148848 ADAM12 / O43184 / ADAM metallopeptidase domain 12  / complex / reaction






 

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