ENSG00000148848


Homo sapiens

Features
Gene ID: ENSG00000148848
  
Biological name :ADAM12
  
Synonyms : ADAM12 / ADAM metallopeptidase domain 12 / O43184
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q26.2
Gene start: 126012381
Gene end: 126388455
  
Corresponding Affymetrix probe sets: 202952_s_at (Human Genome U133 Plus 2.0 Array)   204943_at (Human Genome U133 Plus 2.0 Array)   213790_at (Human Genome U133 Plus 2.0 Array)   215613_at (Human Genome U133 Plus 2.0 Array)   226777_at (Human Genome U133 Plus 2.0 Array)   242460_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357665
Ensembl peptide - ENSP00000357668
Ensembl peptide - ENSP00000391268
NCBI entrez gene - 8038     See in Manteia.
OMIM - 602714
RefSeq - NM_021641
RefSeq - XM_017016705
RefSeq - NM_001288973
RefSeq - NM_001288974
RefSeq - NM_001288975
RefSeq - NM_003474
RefSeq Peptide - NP_067673
RefSeq Peptide - NP_001275904
RefSeq Peptide - NP_003465
RefSeq Peptide - NP_001275903
RefSeq Peptide - NP_001275902
swissprot - Q5JRP2
swissprot - O43184
Ensembl - ENSG00000148848
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam12ENSDARG00000079068Danio rerio
 ADAM12 (1 of many)ENSDARG00000116062Danio rerio
 ADAM12ENSGALG00000041255Gallus gallus
 Adam12ENSMUSG00000054555Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM19 / Q9H013 / ADAM metallopeptidase domain 19ENSG0000013507445
ADAM33 / Q9BZ11 / ADAM metallopeptidase domain 33ENSG0000014945136
ADAM15 / Q13444 / ADAM metallopeptidase domain 15ENSG0000014353734
ADAM8 / P78325 / ADAM metallopeptidase domain 8ENSG0000015165131
ADAM28 / Q9UKQ2 / ADAM metallopeptidase domain 28ENSG0000004298027
ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22ENSG0000000827726
ADAM11 / O75078 / ADAM metallopeptidase domain 11ENSG0000007367024
ADAM23 / O75077 / ADAM metallopeptidase domain 23ENSG0000011494824
ADAM7 / Q9H2U9 / ADAM metallopeptidase domain 7ENSG0000006920624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007520 myoblast fusion TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by EGFR
Invadopodia formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107957 Q5TCZ1 / SH3PXD2A / SH3 and PX domains 2A  / complex / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction






 

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contact: otassy@igbmc.fr