ENSG00000073670


Homo sapiens

Features
Gene ID: ENSG00000073670
  
Biological name :ADAM11
  
Synonyms : ADAM11 / ADAM metallopeptidase domain 11 / O75078
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.31
Gene start: 44759031
Gene end: 44781846
  
Corresponding Affymetrix probe sets: 207880_at (Human Genome U133 Plus 2.0 Array)   239837_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465537
Ensembl peptide - ENSP00000200557
Ensembl peptide - ENSP00000347856
Ensembl peptide - ENSP00000443773
NCBI entrez gene - 4185     See in Manteia.
OMIM - 155120
RefSeq - XM_017024647
RefSeq - NM_001318933
RefSeq - NM_002390
RefSeq - XM_005257373
RefSeq Peptide - NP_001305862
RefSeq Peptide - NP_002381
swissprot - B4DKD2
swissprot - H7BY08
swissprot - K7EKA8
swissprot - O75078
Ensembl - ENSG00000073670
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam11ENSDARG00000079204Danio rerio
 ADAM11ENSGALG00000035673Gallus gallus
 Adam11ENSMUSG00000020926Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22ENSG0000000827753
ADAM23 / O75077 / ADAM metallopeptidase domain 23ENSG0000011494850
ADAM19 / Q9H013 / ADAM metallopeptidase domain 19ENSG0000013507431
ADAM33 / Q9BZ11 / ADAM metallopeptidase domain 33ENSG0000014945130
ADAM12 / O43184 / ADAM metallopeptidase domain 12ENSG0000014884829
ADAM8 / P78325 / ADAM metallopeptidase domain 8ENSG0000015165128
ADAM15 / Q13444 / ADAM metallopeptidase domain 15ENSG0000014353728
ADAM28 / Q9UKQ2 / ADAM metallopeptidase domain 28ENSG0000004298025
ADAM7 / Q9H2U9 / ADAM metallopeptidase domain 7ENSG0000006920624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix ISS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005178 integrin binding TAS
 molecular_functionGO:0008237 metallopeptidase activity IEA


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000153902 LGI4 / Q8N135 / leucine rich repeat LGI family member 4  / complex / reaction
 ENSG00000108231 LGI1 / O95970 / leucine rich glioma inactivated 1  / complex / reaction






 

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