ENSG00000114948


Homo sapiens

Features
Gene ID: ENSG00000114948
  
Biological name :ADAM23
  
Synonyms : ADAM23 / ADAM metallopeptidase domain 23 / O75077
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q33.3
Gene start: 206443539
Gene end: 206621130
  
Corresponding Affymetrix probe sets: 1559268_at (Human Genome U133 Plus 2.0 Array)   206046_at (Human Genome U133 Plus 2.0 Array)   213808_at (Human Genome U133 Plus 2.0 Array)   244463_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264377
Ensembl peptide - ENSP00000406827
Ensembl peptide - ENSP00000363536
NCBI entrez gene - 8745     See in Manteia.
OMIM - 603710
RefSeq - NM_003812
RefSeq - XM_011512086
RefSeq - XM_005246932
RefSeq Peptide - NP_003803
swissprot - E7EWD3
swissprot - O75077
swissprot - H7C2M6
swissprot - A0A024R3W8
Ensembl - ENSG00000114948
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam23aENSDARG00000062323Danio rerio
 FO818722.1ENSDARG00000112453Danio rerio
 ADAM23ENSGALG00000008582Gallus gallus
 Adam23ENSMUSG00000025964Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM11 / O75078 / ADAM metallopeptidase domain 11ENSG0000007367047
ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22ENSG0000000827746
ADAM19 / Q9H013 / ADAM metallopeptidase domain 19ENSG0000013507429
ADAM33 / Q9BZ11 / ADAM metallopeptidase domain 33ENSG0000014945127
ADAM12 / O43184 / ADAM metallopeptidase domain 12ENSG0000014884827
ADAM15 / Q13444 / ADAM metallopeptidase domain 15ENSG0000014353725
ADAM8 / P78325 / ADAM metallopeptidase domain 8ENSG0000015165124
ADAM28 / Q9UKQ2 / ADAM metallopeptidase domain 28ENSG0000004298023
ADAM7 / Q9H2U9 / ADAM metallopeptidase domain 7ENSG0000006920623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005178 integrin binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008237 metallopeptidase activity IEA


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006116 CACNG3 / O60359 / calcium voltage-gated channel auxiliary subunit gamma 3  / reaction / complex
 ENSG00000075461 CACNG4 / Q9UBN1 / calcium voltage-gated channel auxiliary subunit gamma 4  / reaction / complex
 ENSG00000153012 LGI2 / Q8N0V4 / leucine rich repeat LGI family member 2  / reaction / complex
 ENSG00000168481 LGI3 / Q8N145 / leucine rich repeat LGI family member 3  / reaction / complex
 ENSG00000153902 LGI4 / Q8N135 / leucine rich repeat LGI family member 4  / complex / reaction
 ENSG00000008277 ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22  / reaction / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex / reaction
 ENSG00000166862 CACNG2 / Q9Y698 / calcium voltage-gated channel auxiliary subunit gamma 2  / reaction / complex
 ENSG00000142408 CACNG8 / Q8WXS5 / calcium voltage-gated channel auxiliary subunit gamma 8  / reaction / complex
 ENSG00000108231 LGI1 / O95970 / leucine rich glioma inactivated 1  / complex / reaction






 

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