ENSG00000142408


Homo sapiens

Features
Gene ID: ENSG00000142408
  
Biological name :CACNG8
  
Synonyms : CACNG8 / calcium voltage-gated channel auxiliary subunit gamma 8 / Q8WXS5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.42
Gene start: 53963040
Gene end: 53990215
  
Corresponding Affymetrix probe sets: 231355_at (Human Genome U133 Plus 2.0 Array)   234750_at (Human Genome U133 Plus 2.0 Array)   234756_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000270458
Ensembl peptide - ENSP00000492637
NCBI entrez gene - 59283     See in Manteia.
OMIM - 606900
RefSeq - NM_031895
RefSeq Peptide - NP_114101
swissprot - A0A1X7SBR8
swissprot - Q8WXS5
Ensembl - ENSG00000142408
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacng8aENSDARG00000020450Danio rerio
 cacng8bENSDARG00000070626Danio rerio
 Cacng8ENSMUSG00000053395Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CACNG4 / Q9UBN1 / calcium voltage-gated channel auxiliary subunit gamma 4ENSG0000007546148
CACNG2 / Q9Y698 / calcium voltage-gated channel auxiliary subunit gamma 2ENSG0000016686246
CACNG3 / O60359 / calcium voltage-gated channel auxiliary subunit gamma 3ENSG0000000611644
CACNG7 / P62955 / calcium voltage-gated channel auxiliary subunit gamma 7ENSG0000010560520
CACNG5 / Q9UF02 / calcium voltage-gated channel auxiliary subunit gamma 5ENSG0000007542920


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR008368  Voltage-dependent calcium channel, gamma subunit
 IPR008372  Voltage-dependent calcium channel, gamma-8 subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport NAS
 biological_processGO:0019226 transmission of nerve impulse IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0070588 calcium ion transmembrane transport IBA
 biological_processGO:2000311 regulation of AMPA receptor activity IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex NAS
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0032281 AMPA glutamate receptor complex ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IBA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0016247 channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Trafficking of AMPA receptors
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex
 ENSG00000114948 ADAM23 / O75077 / ADAM metallopeptidase domain 23  / complex / reaction
 ENSG00000008277 ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22  / complex
 ENSG00000108231 LGI1 / O95970 / leucine rich glioma inactivated 1  / complex / reaction






 

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