ENSG00000008277


Homo sapiens

Features
Gene ID: ENSG00000008277
  
Biological name :ADAM22
  
Synonyms : ADAM22 / ADAM metallopeptidase domain 22 / Q9P0K1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q21.12
Gene start: 87934143
Gene end: 88202889
  
Corresponding Affymetrix probe sets: 1555024_at (Human Genome U133 Plus 2.0 Array)   206615_s_at (Human Genome U133 Plus 2.0 Array)   206616_s_at (Human Genome U133 Plus 2.0 Array)   208226_x_at (Human Genome U133 Plus 2.0 Array)   208227_x_at (Human Genome U133 Plus 2.0 Array)   208237_x_at (Human Genome U133 Plus 2.0 Array)   213411_at (Human Genome U133 Plus 2.0 Array)   244194_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396233
Ensembl peptide - ENSP00000391334
Ensembl peptide - ENSP00000412085
Ensembl peptide - ENSP00000413899
Ensembl peptide - ENSP00000265727
Ensembl peptide - ENSP00000381260
Ensembl peptide - ENSP00000381261
Ensembl peptide - ENSP00000381262
Ensembl peptide - ENSP00000381267
NCBI entrez gene - 53616     See in Manteia.
OMIM - 603709
RefSeq - XM_017012341
RefSeq - XM_011516320
RefSeq - XM_011516321
RefSeq - XM_011516322
RefSeq - XM_011516323
RefSeq - XM_011516324
RefSeq - XM_017012329
RefSeq - XM_017012330
RefSeq - XM_017012331
RefSeq - XM_017012332
RefSeq - XM_017012333
RefSeq - XM_017012334
RefSeq - XM_017012335
RefSeq - XM_017012336
RefSeq - XM_017012337
RefSeq - XM_017012338
RefSeq - XM_017012339
RefSeq - NM_001324417
RefSeq - NM_001324418
RefSeq - NM_001324419
RefSeq - NM_001324420
RefSeq - NM_001324421
RefSeq - NM_004194
RefSeq - NM_016351
RefSeq - NM_021721
RefSeq - NM_021722
RefSeq - NM_021723
RefSeq - XM_005250445
RefSeq - XM_006716028
RefSeq - XM_006716029
RefSeq - XM_011516318
RefSeq - XM_011516319
RefSeq Peptide - NP_001311347
RefSeq Peptide - NP_004185
RefSeq Peptide - NP_057435
RefSeq Peptide - NP_068367
RefSeq Peptide - NP_068368
RefSeq Peptide - NP_068369
RefSeq Peptide - NP_001311346
RefSeq Peptide - NP_001311348
RefSeq Peptide - NP_001311349
RefSeq Peptide - NP_001311350
swissprot - F8WAD8
swissprot - H7C0Q9
swissprot - H7C3I4
swissprot - E7EPF1
swissprot - E9PF78
swissprot - Q9P0K1
Ensembl - ENSG00000008277
  
Related genetic diseases (OMIM): 617933 - ?Epileptic encephalopathy, early infantile, 61, 617933
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam22ENSDARG00000060532Danio rerio
 ADAM22ENSGALG00000008976Gallus gallus
 Adam22ENSMUSG00000040537Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM11 / O75078 / ADAM metallopeptidase domain 11ENSG0000007367045
ADAM23 / O75077 / ADAM metallopeptidase domain 23ENSG0000011494842
ADAM19 / Q9H013 / ADAM metallopeptidase domain 19ENSG0000013507428
ADAM12 / O43184 / ADAM metallopeptidase domain 12ENSG0000014884826
ADAM33 / Q9BZ11 / ADAM metallopeptidase domain 33ENSG0000014945124
ADAM15 / Q13444 / ADAM metallopeptidase domain 15ENSG0000014353724
ADAM8 / P78325 / ADAM metallopeptidase domain 8ENSG0000015165123
ADAM28 / Q9UKQ2 / ADAM metallopeptidase domain 28ENSG0000004298022
ADAM7 / Q9H2U9 / ADAM metallopeptidase domain 7ENSG0000006920621


Protein motifs (from Interpro)
Interpro ID Name
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007162 negative regulation of cell adhesion NAS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0014037 Schwann cell differentiation IEA
 biological_processGO:0022011 myelination in peripheral nervous system IEA
 biological_processGO:0042063 gliogenesis IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005178 integrin binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008237 metallopeptidase activity IEA


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006116 CACNG3 / O60359 / calcium voltage-gated channel auxiliary subunit gamma 3  / complex
 ENSG00000075461 CACNG4 / Q9UBN1 / calcium voltage-gated channel auxiliary subunit gamma 4  / complex
 ENSG00000114948 ADAM23 / O75077 / ADAM metallopeptidase domain 23  / reaction / complex
 ENSG00000153902 LGI4 / Q8N135 / leucine rich repeat LGI family member 4  / complex / reaction
 ENSG00000168481 LGI3 / Q8N145 / leucine rich repeat LGI family member 3  / complex / reaction
 ENSG00000153012 LGI2 / Q8N0V4 / leucine rich repeat LGI family member 2  / complex / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex
 ENSG00000166862 CACNG2 / Q9Y698 / calcium voltage-gated channel auxiliary subunit gamma 2  / complex
 ENSG00000142408 CACNG8 / Q8WXS5 / calcium voltage-gated channel auxiliary subunit gamma 8  / complex
 ENSG00000108231 LGI1 / O95970 / leucine rich glioma inactivated 1  / reaction / complex






 

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