ENSMUSG00000040537


Mus musculus

Features
Gene ID: ENSMUSG00000040537
  
Biological name :Adam22
  
Synonyms : Adam22 / Disintegrin and metalloproteinase domain-containing protein 22 / Q9R1V6
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 22 / Q9P0K1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A1
Gene start: 8072352
Gene end: 8368160
  
Corresponding Affymetrix probe sets: 10528038 (MoGene1.0st)   1435293_at (Mouse Genome 430 2.0 Array)   1451812_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122652
Ensembl peptide - ENSMUSP00000122758
Ensembl peptide - ENSMUSP00000143097
Ensembl peptide - ENSMUSP00000142580
Ensembl peptide - ENSMUSP00000138353
Ensembl peptide - ENSMUSP00000123196
Ensembl peptide - ENSMUSP00000049120
Ensembl peptide - ENSMUSP00000055000
Ensembl peptide - ENSMUSP00000086122
Ensembl peptide - ENSMUSP00000086139
Ensembl peptide - ENSMUSP00000111043
Ensembl peptide - ENSMUSP00000111044
Ensembl peptide - ENSMUSP00000111046
Ensembl peptide - ENSMUSP00000115775
Ensembl peptide - ENSMUSP00000116422
Ensembl peptide - ENSMUSP00000116736
Ensembl peptide - ENSMUSP00000118571
Ensembl peptide - ENSMUSP00000119409
Ensembl peptide - ENSMUSP00000120995
Ensembl peptide - ENSMUSP00000121156
Ensembl peptide - ENSMUSP00000122426
NCBI entrez gene - 11496     See in Manteia.
MGI - MGI:1340046
RefSeq - XM_006503542
RefSeq - NM_001007220
RefSeq - NM_001007221
RefSeq - NM_001098225
RefSeq - NM_001310439
RefSeq - NM_001310440
RefSeq - XM_006503528
RefSeq - XM_006503529
RefSeq - XM_006503530
RefSeq - XM_006503531
RefSeq - XM_006503532
RefSeq - XM_006503533
RefSeq - XM_006503534
RefSeq - XM_006503535
RefSeq - XM_006503536
RefSeq - XM_006503537
RefSeq - XM_006503540
RefSeq Peptide - NP_001297369
RefSeq Peptide - NP_001007221
RefSeq Peptide - NP_001007222
RefSeq Peptide - NP_001091695
RefSeq Peptide - NP_001297368
swissprot - F7DAP1
swissprot - A0A0G2JE04
swissprot - D3YUQ0
swissprot - D3YUP9
swissprot - A0A0G2JFA9
swissprot - F6PZ09
swissprot - F6SK63
swissprot - F6TDF4
swissprot - F6VJ78
swissprot - F6XIT3
swissprot - F6XRZ6
swissprot - F7AYY9
swissprot - F7BXL9
swissprot - F7BZ55
swissprot - Q9R1V6
swissprot - S4R1S5
swissprot - D6QSS8
swissprot - F7CDH3
Ensembl - ENSMUSG00000040537
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam22ENSDARG00000060532Danio rerio
 ADAM22ENSGALG00000008976Gallus gallus
 ADAM22ENSG00000008277Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam11 / Q9R1V4 / Disintegrin and metalloproteinase domain-containing protein 11 / O75078* / ADAM metallopeptidase domain 11*ENSMUSG0000002092645
Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*ENSMUSG0000002596441
Adam19 / O35674 / Disintegrin and metalloproteinase domain-containing protein 19 / Q9H013* / ADAM metallopeptidase domain 19*ENSMUSG0000001125628
Adam12 / Q61824 / Disintegrin and metalloproteinase domain-containing protein 12 / O43184* / ADAM metallopeptidase domain 12*ENSMUSG0000005455526
Adam15 / O88839 / Disintegrin and metalloproteinase domain-containing protein 15 / Q13444* / ADAM metallopeptidase domain 15*ENSMUSG0000002804123
Adam8 / Q05910 / Disintegrin and metalloproteinase domain-containing protein 8 / P78325* / ADAM metallopeptidase domain 8*ENSMUSG0000002547323
Adam33 / Q923W9 / Disintegrin and metalloproteinase domain-containing protein 33 / Q9BZ11* / ADAM metallopeptidase domain 33*ENSMUSG0000002731823
Adam28 / Q9JLN6 / Disintegrin and metalloproteinase domain-containing protein 28 / Q9UKQ2* / ADAM metallopeptidase domain 28*ENSMUSG0000001472523
Adam7 / O35227 / Disintegrin and metalloproteinase domain-containing protein 7 / Q9H2U9* / ADAM metallopeptidase domain 7*ENSMUSG0000002205622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0014037 Schwann cell differentiation IMP
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0042063 gliogenesis IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008237 metallopeptidase activity IEA


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Adam22tm1.1Mejr/Adam22tm1.1Mejr,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Adam22tm1.1Mejr/Adam22tm1.1Mejr,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag
Genetic Background: involves: C57BL/6 * CBA

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Chd7Whi/Chd7+
Genetic Background: C3HeB/FeJ-Chd7Whi

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039252 Lgi2 / Q8K4Z0 / Leucine-rich repeat LGI family member 2 / Q8N0V4*  / reaction / complex
 ENSMUSG00000036560 Lgi4 / Q8K1S1 / Leucine-rich repeat LGI family member 4 / Q8N135*  / reaction / complex
 ENSMUSG00000033595 Lgi3 / Q8K406 / Leucine-rich repeat LGI family member 3 / Q8N145*  / complex / reaction
 ENSMUSG00000025964 Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*  / reaction / complex
 ENSMUSG00000067242 Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*  / complex / reaction
 ENSMUSG00000020723 Cacng4 / Q9JJV4 / Voltage-dependent calcium channel gamma-4 subunit / Q9UBN1* / calcium voltage-gated channel auxiliary subunit gamma 4*  / complex
 ENSMUSG00000019146 Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit / Q9Y698* / calcium voltage-gated channel auxiliary subunit gamma 2*  / complex
 ENSMUSG00000066189 Cacng3 / Q9JJV5 / Voltage-dependent calcium channel gamma-3 subunit / O60359* / calcium voltage-gated channel auxiliary subunit gamma 3*  / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex






 

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