ENSMUSG00000020723


Mus musculus

Features
Gene ID: ENSMUSG00000020723
  
Biological name :Cacng4
  
Synonyms : Cacng4 / Q9JJV4 / Voltage-dependent calcium channel gamma-4 subunit
  
Possible biological names infered from orthology : calcium voltage-gated channel auxiliary subunit gamma 4 / Q9UBN1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 107732357
Gene end: 107794557
  
Corresponding Affymetrix probe sets: 10392369 (MoGene1.0st)   1450975_at (Mouse Genome 430 2.0 Array)   1455230_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021066
NCBI entrez gene - 54377     See in Manteia.
MGI - MGI:1859167
RefSeq - NM_019431
RefSeq Peptide - NP_062304
swissprot - A2AAU2
swissprot - Q9JJV4
Ensembl - ENSMUSG00000020723
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacng4aENSDARG00000115540Danio rerio
 cacng4bENSDARG00000074669Danio rerio
 CACNG4ENSGALG00000026091Gallus gallus
 CACNG4ENSG00000075461Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacng8 / voltage-dependent calcium channel gamma-8 subunit / Q8WXS5* / calcium voltage-gated channel auxiliary subunit gamma 8*ENSMUSG0000005339564
Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit / Q9Y698* / calcium voltage-gated channel auxiliary subunit gamma 2*ENSMUSG0000001914660
Cacng3 / Q9JJV5 / Voltage-dependent calcium channel gamma-3 subunit / O60359* / calcium voltage-gated channel auxiliary subunit gamma 3*ENSMUSG0000006618956
Cacng5 / Q8VHW4 / Voltage-dependent calcium channel gamma-5 subunit / Q9UF02* / calcium voltage-gated channel auxiliary subunit gamma 5*ENSMUSG0000004037324
Cacng7 / P62956 / Voltage-dependent calcium channel gamma-7 subunit / P62955* / calcium voltage-gated channel auxiliary subunit gamma 7*ENSMUSG0000006980624


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR005423  Voltage-dependent calcium channel, gamma-4 subunit
 IPR008368  Voltage-dependent calcium channel, gamma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0019226 transmission of nerve impulse IGI
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IBA
 biological_processGO:2000311 regulation of AMPA receptor activity IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex ISS
 cellular_componentGO:0036477 somatodendritic compartment IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IBA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0016247 channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Trafficking of AMPA receptors
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: B6.129-Cacng4tm1Frk

Allelic Composition: Cacng2stg-3J/Cacng2stg-3J,Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: B6.129-Cacng4tm1Frk

Allelic Composition: Cacng4tm1Dgen/Cacng4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: B6.129-Cacng4tm1Frk

Allelic Composition: Cacng2stg-3J/Cacng2stg-3J,Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J

Allelic Composition: Cacng2stg-3J/Cacng2stg-3J,Cacng4tm1Frk/Cacng4+
Genetic Background: involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J

Allelic Composition: Cacng2stg-3J/Cacng2+,Cacng4tm1Frk/Cacng4+
Genetic Background: involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: B6.129-Cacng4tm1Frk

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: B6.129-Cacng4tm1Frk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004110 Cacna1e / calcium voltage-gated channel subunit alpha1 E / Q15878*  / complex
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000025964 Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*  / complex / reaction
 ENSMUSG00000067242 Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*  / complex / reaction
 ENSMUSG00000040537 Adam22 / Q9R1V6 / Disintegrin and metalloproteinase domain-containing protein 22 / Q9P0K1* / ADAM metallopeptidase domain 22*  / complex






 

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