ENSMUSG00000004110


Mus musculus

Features
Gene ID: ENSMUSG00000004110
  
Biological name :Cacna1e
  
Synonyms : Cacna1e / calcium voltage-gated channel subunit alpha1 E
  
Possible biological names infered from orthology : Q15878
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G3
Gene start: 154390731
Gene end: 154884501
  
Corresponding Affymetrix probe sets: 10358928 (MoGene1.0st)   1421692_at (Mouse Genome 430 2.0 Array)   1436260_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148507
Ensembl peptide - ENSMUSP00000153897
Ensembl peptide - ENSMUSP00000004214
Ensembl peptide - ENSMUSP00000140937
NCBI entrez gene - 12290     See in Manteia.
MGI - MGI:106217
RefSeq - XM_017312867
RefSeq - XM_017312795
RefSeq - XM_017312824
RefSeq - XM_017312848
RefSeq - XM_017312855
RefSeq - NM_009782
RefSeq - XM_006529105
RefSeq - XM_011247909
RefSeq - XM_011247916
RefSeq - XM_017312578
RefSeq - XM_017312594
RefSeq - XM_017312613
RefSeq - XM_017312619
RefSeq - XM_017312628
RefSeq - XM_017312642
RefSeq - XM_017312660
RefSeq - XM_017312682
RefSeq - XM_017312712
RefSeq - XM_017312730
RefSeq - XM_017312745
RefSeq - XM_017312766
RefSeq Peptide - NP_033912
swissprot - E9QK20
swissprot - A0A1D5RLU3
swissprot - A0A087WS83
Ensembl - ENSMUSG00000004110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna1eaENSDARG00000062346Danio rerio
 cacna1ebENSDARG00000095614Danio rerio
 CACNA1EENSGALG00000003833Gallus gallus
 Q15878ENSG00000198216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97445 / Cacna1a / Voltage-dependent P/Q-type calcium channel subunit alpha-1A / O00555* / calcium voltage-gated channel subunit alpha1 A*ENSMUSG0000003465659
O55017 / Cacna1b / Voltage-dependent N-type calcium channel subunit alpha-1B / Q00975* / calcium voltage-gated channel subunit alpha1 B*ENSMUSG0000000411357
Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*ENSMUSG0000001596835
Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*ENSMUSG0000005133135
Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*ENSMUSG0000002640733
Cacna1f / calcium voltage-gated channel subunit alpha1 F / O60840*ENSMUSG0000003114233
Nalcn / sodium leak channel, non-selective / Q8IZF0*ENSMUSG0000000019717
Q91ZR5 / Catsper1 / Cation channel sperm-associated protein 1 / Q8NEC5* / cation channel sperm associated 1*ENSMUSG000000384986


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005449  Voltage-dependent calcium channel, R-type, alpha-1 subunit
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cacna1etm1Tsch/Cacna1etm1Tsch
Genetic Background: involves: C57BL/6

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002711 decreased glucagon secretion "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cacna1etm1.1Tsch/Cacna1etm1.1Tsch
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003488 decreased channel response intensity 
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Allelic Composition: Neil1tm1Rsld/Neil1+
Genetic Background: either: B6.129S1-Neil1tm1Rsld or (involves: 129S1/Sv * C57BL/6)

 MP:0003489 increased channel response threshold 
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Allelic Composition: Neil1tm1Rsld/Neil1+
Genetic Background: either: B6.129S1-Neil1tm1Rsld or (involves: 129S1/Sv * C57BL/6)

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003565 abnormal glucagon secretion "anomaly in the release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cacna1etm1.1Tsch/Cacna1etm1.1Tsch
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cacna1etm1.1Tsch/Cacna1etm1.1Tsch
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1etm1.1Tsch/Cacna1etm1.1Tsch
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010066 Q6PHS9 / Cacna2d2 / Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 / Q9NY47*...  / complex
 ENSMUSG00000020723 Cacng4 / Q9JJV4 / Voltage-dependent calcium channel gamma-4 subunit / Q9UBN1* / calcium voltage-gated channel auxiliary subunit gamma 4*  / complex






 

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