ENSMUSG00000000197


Mus musculus

Features
Gene ID: ENSMUSG00000000197
  
Biological name :Nalcn
  
Synonyms : Nalcn / sodium leak channel, non-selective
  
Possible biological names infered from orthology : Q8IZF0
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E5
Gene start: 123276634
Gene end: 123627144
  
Corresponding Affymetrix probe sets: 10422537 (MoGene1.0st)   1448083_at (Mouse Genome 430 2.0 Array)   1457423_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000201
NCBI entrez gene - 338370     See in Manteia.
MGI - MGI:2444306
RefSeq - XM_017316066
RefSeq - NM_177393
RefSeq - XM_017316064
RefSeq - XM_017316065
RefSeq - XM_011245094
RefSeq - XM_017316062
RefSeq - XM_017316063
RefSeq Peptide - NP_796367
swissprot - E9QLE4
Ensembl - ENSMUSG00000000197
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nalcnENSDARG00000001835Danio rerio
 NALCNENSGALG00000016868Gallus gallus
 NALCNENSG00000102452Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97445 / Cacna1a / Voltage-dependent P/Q-type calcium channel subunit alpha-1A / O00555* / calcium voltage-gated channel subunit alpha1 A*ENSMUSG0000003465622
Cacna1e / calcium voltage-gated channel subunit alpha1 E / Q15878*ENSMUSG0000000411022
Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*ENSMUSG0000001596822
Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*ENSMUSG0000005133122
Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*ENSMUSG0000002640721
O55017 / Cacna1b / Voltage-dependent N-type calcium channel subunit alpha-1B / Q00975* / calcium voltage-gated channel subunit alpha1 B*ENSMUSG0000000411321
Cacna1f / calcium voltage-gated channel subunit alpha1 F / O60840*ENSMUSG0000003114221
Q91ZR5 / Catsper1 / Cation channel sperm-associated protein 1 / Q8NEC5* / cation channel sperm associated 1*ENSMUSG000000384985


Protein motifs (from Interpro)
Interpro ID Name
 IPR005821  Ion transport domain
 IPR028823  Sodium leak channel non-selective protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: NalcnDrl/Nalcn+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Nalcntm1c(KOMP)Wtsi/Nalcntm1c(KOMP)Wtsi,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nalcntm1c(KOMP)Wtsi/Nalcntm1c(KOMP)Wtsi,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: NalcnDrl/Nalcn+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Nalcntm1c(KOMP)Wtsi/Nalcntm1c(KOMP)Wtsi,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0012288 abnormal paradoxical sleep pattern "any anomaly in the frequency or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [MGI:csmith]
Show

Allelic Composition: NalcnDrl/Nalcn+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Nalcnem1Iiis/Nalcn+
Genetic Background: Not Specified

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: NalcnDrl/Nalcn+
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055567 Unc80 / unc-80, NALCN activator / Q8N2C7* / unc-80 homolog, NALCN channel complex subunit*  / complex
 ENSMUSG00000021198 Unc79 / Q0KK59 / unc-79 homolog (C. elegans) / Q9P2D8* / unc-79 homolog, NALCN channel complex subunit*  / complex






 

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