ENSMUSG00000021198


Mus musculus

Features
Gene ID: ENSMUSG00000021198
  
Biological name :Unc79
  
Synonyms : Q0KK59 / Unc79 / unc-79 homolog (C. elegans)
  
Possible biological names infered from orthology : Q9P2D8 / unc-79 homolog, NALCN channel complex subunit
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 102948859
Gene end: 103184065
  
Corresponding Affymetrix probe sets: 10397912 (MoGene1.0st)   1457422_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137320
Ensembl peptide - ENSMUSP00000136888
Ensembl peptide - ENSMUSP00000137132
Ensembl peptide - ENSMUSP00000082156
Ensembl peptide - ENSMUSP00000098659
Ensembl peptide - ENSMUSP00000136293
Ensembl peptide - ENSMUSP00000136332
NCBI entrez gene - 217843     See in Manteia.
MGI - MGI:2684729
RefSeq - XM_017315040
RefSeq - XM_006515750
RefSeq - XM_006515751
RefSeq - XM_006515752
RefSeq - XM_006515753
RefSeq - XM_006515756
RefSeq - XM_017315037
RefSeq - XM_017315038
RefSeq - XM_017315039
RefSeq - NM_001081017
RefSeq - XM_006515743
RefSeq - XM_006515744
RefSeq - XM_006515745
RefSeq - XM_006515746
RefSeq - XM_006515747
RefSeq - XM_006515748
RefSeq - XM_006515749
RefSeq Peptide - NP_001074486
swissprot - J3QNP0
swissprot - J3QP77
swissprot - J3QPJ0
swissprot - G8JL63
swissprot - E5CYJ9
swissprot - J3QMH8
swissprot - Q0KK59
Ensembl - ENSMUSG00000021198
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000045221Gallus gallus
 ENSGALG00000010874Gallus gallus
 UNC79ENSG00000133958Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016024  Armadillo-type fold
 IPR024855  UNC79


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0048149 behavioral response to ethanol IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Slc12a5tm1Dlp/Slc12a5+
Genetic Background: involves: C57BL/6J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Slc12a5tm1Dlp/Slc12a5+
Genetic Background: involves: C57BL/6J

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pdia3tm1Gjh/Pdia3tm1Gjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

 MP:0001987 alcohol preference 
Show

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002849 saccharin consumption "subjects demonstrate interest in ingesting saccharine " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

 MP:0002850 saccharin preference "subjects demonstrate desire for saccharine over other offered substance" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Slc12a5tm1Dlp/Slc12a5+
Genetic Background: involves: C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a5tm1Dlp/Slc12a5+
Genetic Background: involves: C57BL/6J

 MP:0009751 enhanced behavioral response to alcohol "increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

 MP:0009778 impaired behavioral response to anesthetic "decrease or delay in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc12a5tm1Dlp/Slc12a5+
Genetic Background: involves: C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Slc12a5tm1Dlp/Slc12a5+
Genetic Background: involves: C57BL/6J

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055567 Unc80 / unc-80, NALCN activator / Q8N2C7* / unc-80 homolog, NALCN channel complex subunit*  / complex
 ENSMUSG00000000197 Nalcn / sodium leak channel, non-selective / Q8IZF0*  / complex






 

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