ENSMUSG00000031142


Mus musculus

Features
Gene ID: ENSMUSG00000031142
  
Biological name :Cacna1f
  
Synonyms : Cacna1f / calcium voltage-gated channel subunit alpha1 F
  
Possible biological names infered from orthology : O60840
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.1
Gene start: 7607083
Gene end: 7635196
  
Corresponding Affymetrix probe sets: 10598309 (MoGene1.0st)   1449955_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115012
Ensembl peptide - ENSMUSP00000138116
Ensembl peptide - ENSMUSP00000119207
Ensembl peptide - ENSMUSP00000116051
Ensembl peptide - ENSMUSP00000111390
Ensembl peptide - ENSMUSP00000111391
NCBI entrez gene - 54652     See in Manteia.
MGI - MGI:1859639
RefSeq - XM_011247482
RefSeq - NM_019582
RefSeq Peptide - NP_062528
swissprot - B1AVA4
swissprot - B1AVA6
swissprot - Q7TNI3
swissprot - Q8C8Q4
swissprot - S4R182
swissprot - B1AVA5
Ensembl - ENSMUSG00000031142
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna1faENSDARG00000010933Danio rerio
 cacna1fbENSDARG00000023683Danio rerio
 FO082780.1ENSDARG00000115528Danio rerio
 O60840ENSG00000102001Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*ENSMUSG0000001596865
Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*ENSMUSG0000005133163
Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*ENSMUSG0000002640755
O55017 / Cacna1b / Voltage-dependent N-type calcium channel subunit alpha-1B / Q00975* / calcium voltage-gated channel subunit alpha1 B*ENSMUSG0000000411339
P97445 / Cacna1a / Voltage-dependent P/Q-type calcium channel subunit alpha-1A / O00555* / calcium voltage-gated channel subunit alpha1 A*ENSMUSG0000003465639
Cacna1e / calcium voltage-gated channel subunit alpha1 E / Q15878*ENSMUSG0000000411038
Nalcn / sodium leak channel, non-selective / Q8IZF0*ENSMUSG0000000019718
Q91ZR5 / Catsper1 / Cation channel sperm-associated protein 1 / Q8NEC5* / cation channel sperm associated 1*ENSMUSG000000384986


Protein motifs (from Interpro)
Interpro ID Name
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005446  Voltage-dependent calcium channel, L-type, alpha-1 subunit
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR030157  Voltage-dependent calcium channel, L-type, alpha-1F subunit
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain
 IPR031688  Voltage-gated calcium channel subunit alpha, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0050856 regulation of T cell receptor signaling pathway IEA
 biological_processGO:0050908 detection of light stimulus involved in visual perception IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * CD-1)

Allelic Composition: Cacna1ftm1Ntbh/Cacna1ftm1Ntbh
Genetic Background: B6.129-Cacna1ftm1Ntbh

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1fnob2/Cacna1fnob2
Genetic Background: AXB6/PgnJ

Allelic Composition: Cacna1fnob2/Y
Genetic Background: AXB6/PgnJ

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1fnob2/Cacna1fnob2
Genetic Background: AXB6/PgnJ

Allelic Composition: Cacna1fnob2/Y
Genetic Background: AXB6/PgnJ

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1fnob2/Cacna1fnob2
Genetic Background: AXB6/PgnJ

Allelic Composition: Cacna1fnob2/Y
Genetic Background: AXB6/PgnJ

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * CD-1)

Allelic Composition: Cacna1ftm1Ntbh/Cacna1ftm1Ntbh
Genetic Background: B6.129-Cacna1ftm1Ntbh

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * CD-1)

Allelic Composition: Cacna1ftm1Ntbh/Cacna1ftm1Ntbh
Genetic Background: B6.129-Cacna1ftm1Ntbh

Allelic Composition: Cacna1fnob2/Cacna1fnob2
Genetic Background: AXB6/PgnJ

Allelic Composition: Cacna1fnob2/Y
Genetic Background: AXB6/PgnJ

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * CD-1)

Allelic Composition: Cacna1ftm1Ntbh/Cacna1ftm1Ntbh
Genetic Background: B6.129-Cacna1ftm1Ntbh

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * CD-1)

Allelic Composition: Cacna1ftm1Ntbh/Cacna1ftm1Ntbh
Genetic Background: B6.129-Cacna1ftm1Ntbh

Allelic Composition: Cacna1fnob2/Cacna1fnob2
Genetic Background: AXB6/PgnJ

Allelic Composition: Cacna1fnob2/Y
Genetic Background: AXB6/PgnJ

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1fnob2/Cacna1fnob2
Genetic Background: AXB6/PgnJ

Allelic Composition: Cacna1fnob2/Y
Genetic Background: AXB6/PgnJ

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * CD-1)

Allelic Composition: Cacna1ftm1Ntbh/Cacna1ftm1Ntbh
Genetic Background: B6.129-Cacna1ftm1Ntbh

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

 MP:0008520 disorganized retinal outer plexiform layer "a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1fnob2/Cacna1fnob2
Genetic Background: AXB6/PgnJ

Allelic Composition: Cacna1fnob2/Y
Genetic Background: AXB6/PgnJ

 MP:0009392 retinal gliosis "increased proliferation of neuroglia in a damaged area of the retina that may lead to the formation of scar tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0010749 absent visual evoked potential "absence of a characteristic electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; absence may indicate blindness" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * CD-1)

Allelic Composition: Cacna1ftm1Ntbh/Cacna1ftm1Ntbh
Genetic Background: B6.129-Cacna1ftm1Ntbh

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * CD-1)

Allelic Composition: Cacna1ftm1Ntbh/Cacna1ftm1Ntbh
Genetic Background: B6.129-Cacna1ftm1Ntbh

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0012034 abnormal a wave shape "any anomaly in the graphical representation of the a wave in the electroretinogram; the a wave represents the general physiological health of the photoreceptors in the outer retina" [http://webvision.med.utah.edu, MGI:csmith]
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Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

 MP:0012035 abnormal b-wave shape "any anomaly in the graphical representation of the b wave in the electroretinogram; the b wave represents the health of the inner layers of the retina, including the ON bipolar cells and the Muller cells" [http://webvision.med.utah.edu, MGI:csmith]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
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Allelic Composition: Cacna1ftm1.1Sdie/Y
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.1Sdie/Cacna1ftm1.1Sdie
Genetic Background: B6.Cg-Cacna1ftm1.1Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
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Allelic Composition: Cacna1ftm1.1Sdie/Cacna1f+
Genetic Background: involves: C57BL/6

Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Cacna1ftm1.2Sdie/Cacna1ftm1.2Sdie
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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