ENSMUSG00000034656


Mus musculus

Features
Gene ID: ENSMUSG00000034656
  
Biological name :Cacna1a
  
Synonyms : Cacna1a / P97445 / Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  
Possible biological names infered from orthology : calcium voltage-gated channel subunit alpha1 A / O00555
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C2
Gene start: 84388440
Gene end: 84640246
  
Corresponding Affymetrix probe sets: 10573348 (MoGene1.0st)   1430408_at (Mouse Genome 430 2.0 Array)   1444455_at (Mouse Genome 430 2.0 Array)   1450510_a_at (Mouse Genome 430 2.0 Array)   1459996_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149242
Ensembl peptide - ENSMUSP00000112436
Ensembl peptide - ENSMUSP00000114055
NCBI entrez gene - 12286     See in Manteia.
MGI - MGI:109482
RefSeq - XM_017312540
RefSeq - XM_006530603
RefSeq - XM_006530604
RefSeq - XM_006530605
RefSeq - XM_006530607
RefSeq - XM_006530608
RefSeq - XM_006530609
RefSeq - XM_011248285
RefSeq - NM_001252059
RefSeq - NM_001252060
RefSeq - NM_001252061
RefSeq - NM_007578
RefSeq - XM_006530587
RefSeq - XM_006530588
RefSeq - XM_006530589
RefSeq - XM_006530590
RefSeq - XM_006530591
RefSeq - XM_006530592
RefSeq - XM_006530593
RefSeq - XM_006530594
RefSeq - XM_006530595
RefSeq - XM_006530596
RefSeq - XM_006530597
RefSeq - XM_006530598
RefSeq - XM_006530599
RefSeq - XM_006530600
RefSeq - XM_006530601
RefSeq - XM_006530602
RefSeq Peptide - NP_031604
RefSeq Peptide - NP_001238988
RefSeq Peptide - NP_001238989
RefSeq Peptide - NP_001238990
swissprot - P97445
swissprot - E9Q1R5
swissprot - A0A1L1SQZ2
Ensembl - ENSMUSG00000034656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna1aaENSDARG00000037905Danio rerio
 cacna1abENSDARG00000006923Danio rerio
 O00555ENSG00000141837Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O55017 / Cacna1b / Voltage-dependent N-type calcium channel subunit alpha-1B / Q00975* / calcium voltage-gated channel subunit alpha1 B*ENSMUSG0000000411362
Cacna1e / calcium voltage-gated channel subunit alpha1 E / Q15878*ENSMUSG0000000411056
Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*ENSMUSG0000005133136
Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*ENSMUSG0000001596835
Cacna1f / calcium voltage-gated channel subunit alpha1 F / O60840*ENSMUSG0000003114233
Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*ENSMUSG0000002640732
Nalcn / sodium leak channel, non-selective / Q8IZF0*ENSMUSG0000000019716
Q91ZR5 / Catsper1 / Cation channel sperm-associated protein 1 / Q8NEC5* / cation channel sperm associated 1*ENSMUSG000000384986


Protein motifs (from Interpro)
Interpro ID Name
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005448  Voltage-dependent calcium channel, P/Q-type, alpha-1 A
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001505 regulation of neurotransmitter levels IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IMP
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007270 neuron-neuron synaptic transmission IMP
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0008219 cell death ISO
 biological_processGO:0010817 regulation of hormone levels IMP
 biological_processGO:0014051 gamma-aminobutyric acid secretion IMP
 biological_processGO:0014056 regulation of acetylcholine secretion, neurotransmission IMP
 biological_processGO:0017156 calcium ion regulated exocytosis IMP
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IDA
 biological_processGO:0019226 transmission of nerve impulse IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0021590 cerebellum maturation IMP
 biological_processGO:0021679 cerebellar molecular layer development IMP
 biological_processGO:0021680 cerebellar Purkinje cell layer development IMP
 biological_processGO:0021702 cerebellar Purkinje cell differentiation IMP
 biological_processGO:0021750 vestibular nucleus development IMP
 biological_processGO:0021953 central nervous system neuron differentiation IMP
 biological_processGO:0030644 cellular chloride ion homeostasis IMP
 biological_processGO:0031335 regulation of sulfur amino acid metabolic process IMP
 biological_processGO:0032353 negative regulation of hormone biosynthetic process IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IMP
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043113 receptor clustering IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0048266 behavioral response to pain IMP
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IMP
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0050770 regulation of axonogenesis IMP
 biological_processGO:0050877 nervous system process IMP
 biological_processGO:0050883 musculoskeletal movement, spinal reflex action IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0050905 neuromuscular process IMP
 biological_processGO:0051899 membrane depolarization IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060024 rhythmic synaptic transmission IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 biological_processGO:1904645 response to amyloid-beta ISO
 biological_processGO:1904646 cellular response to amyloid-beta ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0042995 cell projection ISO
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008331 high voltage-gated calcium channel activity ISS
 molecular_functionGO:0019905 syntaxin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm1Maag/Cacna1atm1Maag
Genetic Background: B6.129P2-Cacna1atm1Maag

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

Allelic Composition: Cacna1atm2.1Kewa/Cacna1a+
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa,Ctsbtm1Jde/Ctsbtm1Jde
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cacna1atm3Hzo/Cacna1atm3Hzo,Ctsbtm1Jde/Ctsbtm1Jde
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1atg-4J/Cacna1atg-4J
Genetic Background: B6.C3Bir-Cacna1atg-4J

Allelic Composition: Cacna1aTg-5J/Cacna1a+,Tg(Pvalb-EGFP)B20Zjh/?
Genetic Background: involves: BALB/cByJ * C57BL/6 * C57BL/10J

Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

Allelic Composition: Cacna1atm3Hzo/Cacna1atm3Hzo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa,Ctsbtm1Jde/Ctsbtm1Jde
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Cacna1atg/Cacna1atg,Tg(Pcp2-TAg)4Horr/0
Genetic Background: B6J.Cg-Cacna1atg Tg(Pcp2-TAg)4Horr

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Cacna1aWb/Cacna1a+
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1aWb/Cacna1aWb
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Amntm1Ehl/Amntm1Ehl
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.2Maag,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cacna1aWb/Cacna1aWb
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1aTg-5J/Cacna1aTg-5J
Genetic Background: involves: BALB/cByJ * C57BL/10J

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1.2Sher/Cacna1atm1.2Sher
Genetic Background: involves: 129S4/SvJae

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Serpina6tm1.1Mmp/Serpina6+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.2Maag,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: B6.D2-Cacna1atg/J

Allelic Composition: Cacna1aWb/Cacna1a+
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1aWb/Cacna1aWb
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1atg-la/Cacna1aWb
Genetic Background: involves: AKR/J * C3H/HeJ * C57BL/6J

Allelic Composition: Cacna1atm1(CACNA1A)Ttan/Cacna1atm1(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cacna1atm1.1(CACNA1A)Ttan/Cacna1atm1.1(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cacna1atm2.1(CACNA1A)Ttan/Cacna1atm2.1(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cacna1atg-4J/Cacna1atg-4J
Genetic Background: B6.C3Bir-Cacna1atg-4J

Allelic Composition: Cacna1aTg-5J/Cacna1aTg-5J
Genetic Background: involves: BALB/cByJ * C57BL/10J

Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1Nobs/Cacna1atm1Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm2Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1aTg-7J/Cacna1a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cacna1atg-rol/Cacna1atg
Genetic Background: involves: C3H * C57BL/6 * DBA/2J * SIII

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Cacna1atm1.2Sher/Cacna1atm1.2Sher
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

Allelic Composition: Cacna1atm2.1Kewa/Cacna1a+
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

Allelic Composition: Cacna1atg/Cacna1atg,Tg(Pcp2-TAg)4Horr/0
Genetic Background: B6J.Cg-Cacna1atg Tg(Pcp2-TAg)4Horr

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm1Maag/Cacna1atm1Maag
Genetic Background: B6.129P2-Cacna1atm1Maag

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cacna1aWb/Cacna1a+
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1atm3Hzo/Cacna1atm3Hzo
Genetic Background: involves: 129S/SvEv

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1aWb/Cacna1a+
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1aWb/Cacna1aWb
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1atg-la/Cacna1aWb
Genetic Background: involves: AKR/J * C3H/HeJ * C57BL/6J

Allelic Composition: Cacna1atm1(CACNA1A)Ttan/Cacna1a+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cacna1atm3Hzo/Cacna1atm3Hzo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cacna1atm3Hzo/Cacna1a+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm2Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: B6.D2-Cacna1atg/J

Allelic Composition: Cacna1aTg-7J/Cacna1a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cacna1atg-rol/Cacna1atg
Genetic Background: involves: C3H * C57BL/6 * DBA/2J * SIII

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: DBA/2J * C57BL/10JGn

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: DBA/2J

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm1Maag/Cacna1atm1Maag
Genetic Background: B6.129P2-Cacna1atm1Maag

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1atm3Hzo/Cacna1atm3Hzo
Genetic Background: involves: 129S/SvEv

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1.1Kewa/Cacna1atm1.1Kewa
Genetic Background: B6.Cg-Cacna1atm1.1Kewa

Allelic Composition: Cacna1atm2.1Kewa/Cacna1a+
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa,Ctsbtm1Jde/Ctsbtm1Jde
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa,Ctsbtm1Jde/Ctsb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Cacna1aWb/Cacna1aWb
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001908 abnormal somatosensory cortex function "anomalous activity of the area of the parietal lobe concerned with receiving general sensations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcne2tm1Gwab/Kcne2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: DBA/2J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amntm1Ehl/Amntm1Ehl
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm1.2Sher/Cacna1atm1.2Sher
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cacna1atg-4J/Cacna1atg-4J
Genetic Background: B6.C3Bir-Cacna1atg-4J

Allelic Composition: Cacna1atm1Nobs/Cacna1atm1Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyr61tm1Lfl/Cyr61+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cacna1atg-rol/Cacna1a+
Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cacna1aWb/Cacna1aWb
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1aTg-5J/Cacna1aTg-5J
Genetic Background: involves: BALB/cByJ * C57BL/10J

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1Nobs/Cacna1atm1Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1.2Sher/Cacna1atm1.2Sher
Genetic Background: involves: 129S4/SvJae

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.2Maag,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cacna1atm1.1Kewa/Cacna1atm1.1Kewa
Genetic Background: B6.Cg-Cacna1atm1.1Kewa

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: C57BL/6J

Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: B6.D2-Cacna1atg/J

Allelic Composition: Cacna1atg-4J/Cacna1atg-4J
Genetic Background: B6.C3Bir-Cacna1atg-4J

Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm3Maag/Cacna1a+
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm1Maag/Cacna1atm1Maag
Genetic Background: B6.129P2-Cacna1atm1Maag

Allelic Composition: Cacna1atm1Maag/Cacna1a+
Genetic Background: B6.129P2-Cacna1atm1Maag

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cacna1atm3Hzo/Cacna1atm3Hzo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: B6.D2-Cacna1atg/J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: Not Specified

Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

 MP:0002913 abnormal PNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Cacna1atm1.2Sher/Cacna1atm1.2Sher
Genetic Background: involves: 129S4/SvJae

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1Maag/Cacna1atm1Maag
Genetic Background: B6.129P2-Cacna1atm1Maag

Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cacna1atm3Maag/Cacna1a+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Cacna1atg-4J/Cacna1atg-4J
Genetic Background: B6.C3Bir-Cacna1atg-4J

Allelic Composition: Cacna1atm2Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0003477 abnormal nerve fiber response "anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J

 MP:0003481 decreased nerve fiber response intensity 
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J

Allelic Composition: Cacna1atm1Hzo/Cacna1atm1Hzo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cacna1atm2Hzo/Cacna1atm2Hzo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cacna1atm3Hzo/Cacna1atm3Hzo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: C57BL/6J

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Cacna1atm1.1Ehess/Cacna1atm1.1Ehess
Genetic Background: C57BL/6-Cacna1atm1.1Ehess

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Cacna1atg-rol/Cacna1atg
Genetic Background: involves: C3H * C57BL/6 * DBA/2J * SIII

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII

Allelic Composition: Cacna1atg-rol/Cacna1a+
Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C3Hf/Nga * C57BL/6 * SIII

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.2Maag,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003996 clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm2Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004145 abnormal muscle electrophysiology "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: B6.D2-Cacna1atg/J

Allelic Composition: Cacna1atg/Cacna1atm2.1Maag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * FVB/N

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: B6.D2-Cacna1atg/J

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0004836 abnormal synaptic acetylcholine release "aberrant secretion across synapses of the excitatory neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.2Maag,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: C57BL/6J

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.2Maag,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: B6.D2-Cacna1atg/J

Allelic Composition: Cacna1aWb/Cacna1aWb
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1atg-la/Cacna1aWb
Genetic Background: involves: AKR/J * C3H/HeJ * C57BL/6J

Allelic Composition: Cacna1atm1(CACNA1A)Ttan/Cacna1atm1(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cacna1atm1.1(CACNA1A)Ttan/Cacna1atm1.1(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cacna1atm2.1(CACNA1A)Ttan/Cacna1atm2.1(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cacna1atg/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J * FVB/N

Allelic Composition: Cacna1atg/Cacna1atm2.1Maag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * FVB/N

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hrktm1Ast/Hrktm1Ast
Genetic Background: C57BL/6-Hrktm1Ast

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1atg-4J/Cacna1atg-4J
Genetic Background: B6.C3Bir-Cacna1atg-4J

Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: 129 * C57BL/6J

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrktm1Ast/Hrktm1Ast
Genetic Background: C57BL/6-Hrktm1Ast

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1Maag/Cacna1atm1Maag
Genetic Background: B6.129P2-Cacna1atm1Maag

Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cacna1atm3Maag/Cacna1a+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006099 thin granule layer "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Cacna1atg-4J/Cacna1atg-4J
Genetic Background: B6.C3Bir-Cacna1atg-4J

Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Genetic Background: B6.Cg-Cacna1atm2.1Kewa

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
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Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: involves: C57BL/6J

Allelic Composition: Cacna1atm2Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm3Maag/Cacna1a+
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm1Maag/Cacna1atm1Maag
Genetic Background: B6.129P2-Cacna1atm1Maag

Allelic Composition: Cacna1atm1Maag/Cacna1a+
Genetic Background: B6.129P2-Cacna1atm1Maag

 MP:0008921 increased neurotransmitter release "increased production or release of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0009357 induced seizures "applied stimulation producing uncontrolled electrical activity in the brain, producing a physical convulsion or minor change in physical behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Cacna1atm1Hssh/Cacna1atm1Hssh
Genetic Background: Not Specified

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm3Maag/Cacna1a+
Genetic Background: B6.129P2-Cacna1atm3Maag

Allelic Composition: Cacna1atm1Maag/Cacna1atm1Maag
Genetic Background: B6.129P2-Cacna1atm1Maag

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cacna1atm3Maag/Cacna1a+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm3Maag/Cacna1atm3Maag
Genetic Background: B6.129P2-Cacna1atm3Maag

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Cacna1aWb/Cacna1aWb
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1atg-la/Cacna1aWb
Genetic Background: involves: AKR/J * C3H/HeJ * C57BL/6J

Allelic Composition: Cacna1atm1.1Sher/Cacna1atm1.1Sher,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.2Maag,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cacna1atm1(CACNA1A)Ttan/Cacna1atm1(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cacna1atm2(CACNA1A)Ttan/Cacna1atm2(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cacna1atm1.1(CACNA1A)Ttan/Cacna1atm1.1(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cacna1atm2.1(CACNA1A)Ttan/Cacna1atm2.1(CACNA1A)Ttan
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cacna1atm1Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Cacna1asmrl/Cacna1asmrl
Genetic Background: CXB10/HiAJ-Cacna1asmrl/GrsrJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cacna1aTg-5J/Cacna1aTg-5J
Genetic Background: involves: BALB/cByJ * C57BL/10J

 MP:0011267 abnormal excitatory postsynaptic current amplitude "anomaly in the size (height or maximum displacement) or shape of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: B6.D2-Cacna1atg/J

 MP:0014185 cerebellum atrophy "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Cacna1aWb/Cacna1a+
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1aWb/Cacna1aWb
Genetic Background: either: C3.B6-Cacna1aWb or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cacna1atm2Nobs/Cacna1atm2Nobs
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019146 Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit / Q9Y698* / calcium voltage-gated channel auxiliary subunit gamma 2*  / complex
 ENSMUSG00000017412 Cacnb4 / Q8R0S4 / Mus musculus calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), transcript variant 6, mRNA. / O00305* / AC068547.1* / calcium voltage-gated channel auxiliary sub...  / complex
 ENSMUSG00000010066 Q6PHS9 / Cacna2d2 / Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 / Q9NY47*...  / complex






 

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