ENSMUSG00000019146


Mus musculus

Features
Gene ID: ENSMUSG00000019146
  
Biological name :Cacng2
  
Synonyms : Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit
  
Possible biological names infered from orthology : calcium voltage-gated channel auxiliary subunit gamma 2 / Q9Y698
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 77991748
Gene end: 78120028
  
Corresponding Affymetrix probe sets: 10430280 (MoGene1.0st)   10430282 (MoGene1.0st)   1420596_at (Mouse Genome 430 2.0 Array)   1440210_at (Mouse Genome 430 2.0 Array)   1453363_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019290
NCBI entrez gene - 12300     See in Manteia.
MGI - MGI:1316660
RefSeq - XM_006520371
RefSeq - NM_007583
RefSeq Peptide - NP_031609
swissprot - O88602
swissprot - Q3ZB20
Ensembl - ENSMUSG00000019146
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacng2aENSDARG00000032565Danio rerio
 CACNG2ENSGALG00000031977Gallus gallus
 CACNG2ENSG00000166862Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacng3 / Q9JJV5 / Voltage-dependent calcium channel gamma-3 subunit / O60359* / calcium voltage-gated channel auxiliary subunit gamma 3*ENSMUSG0000006618974
Cacng8 / voltage-dependent calcium channel gamma-8 subunit / Q8WXS5* / calcium voltage-gated channel auxiliary subunit gamma 8*ENSMUSG0000005339560
Cacng4 / Q9JJV4 / Voltage-dependent calcium channel gamma-4 subunit / Q9UBN1* / calcium voltage-gated channel auxiliary subunit gamma 4*ENSMUSG0000002072360
Cacng7 / P62956 / Voltage-dependent calcium channel gamma-7 subunit / P62955* / calcium voltage-gated channel auxiliary subunit gamma 7*ENSMUSG0000006980625
Cacng5 / Q8VHW4 / Voltage-dependent calcium channel gamma-5 subunit / Q9UF02* / calcium voltage-gated channel auxiliary subunit gamma 5*ENSMUSG0000004037325


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR005422  Voltage-dependent calcium channel, gamma-2 subunit
 IPR008368  Voltage-dependent calcium channel, gamma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0019226 transmission of nerve impulse IGI
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0050877 nervous system process IMP
 biological_processGO:0051899 membrane depolarization IMP
 biological_processGO:0060081 membrane hyperpolarization IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome IMP
 biological_processGO:0098962 regulation of postsynaptic neurotransmitter receptor activity IC
 biological_processGO:0098970 postsynaptic neurotransmitter receptor diffusion trapping IMP
 biological_processGO:0099590 neurotransmitter receptor internalization IMP
 biological_processGO:2000311 regulation of AMPA receptor activity IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IEA
 cellular_componentGO:0036477 somatodendritic compartment IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098839 postsynaptic density membrane IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IMP
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016247 channel regulator activity IBA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Trafficking of AMPA receptors
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cacna1atm3Hzo/Cacna1a+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: involves: A/J

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa,Cacng7tm1Mwa/Cacng7tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: B6.129-Cacng4tm1Frk

Allelic Composition: Cacng2stg-3J/Cacng2stg-3J,Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J

Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

Allelic Composition: Cacng2stg/Cacng2stg,Cacng3tm1Ran/Cacng3tm1Ran
Genetic Background: involves: A/J

Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: involves: A/J

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa,Cacng7tm1Mwa/Cacng7tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa,Cacng7tm1Mwa/Cacng7tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Cacng2stg/Cacng2stg,Cacng3tm1Ran/Cacng3tm1Ran
Genetic Background: involves: A/J

 MP:0002623 abnormal vestibular hair cell morphology "malformation of the sensory epithelial cells of the membraneous labyrinth of the inner ear; these cells are in synaptic contact with the vestibular nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: involves: A/J

Allelic Composition: Cacng2tm1.1Suto/Cacng2tm1.1Suto
Genetic Background: Not Specified

Allelic Composition: Cacng2tm2.1Suto/Cacng2tm2.1Suto
Genetic Background: Not Specified

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacng2stg/Cacng2stg,Cacng3tm1Ran/Cacng3tm1Ran
Genetic Background: involves: A/J

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa,Cacng7tm1Mwa/Cacng7tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
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Allelic Composition: Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: B6.129-Cacng4tm1Frk

Allelic Composition: Cacng2stg-3J/Cacng2stg-3J,Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J

Allelic Composition: Cacng2stg-3J/Cacng2stg-3J,Cacng4tm1Frk/Cacng4+
Genetic Background: involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J

Allelic Composition: Cacng2stg-3J/Cacng2+,Cacng4tm1Frk/Cacng4+
Genetic Background: involves: B6C3-Cacng2stg-3J/J * B6.129-Cacng4tm1Frk/J

Allelic Composition: Cacng2stg-wag/Cacng2stg-wag
Genetic Background: B6.MRL-Cacng2stg-wag/J

Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa,Cacng7tm1Mwa/Cacng7tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0003894 abnormal Purkinje cell innervation "malformation or absence of the supply of nerve fibers that connect to the Purkinje cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0004428 abnormal type I vestibular cell "any structural abnormality in the flask-shaped sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear, which are normally enclosed in calyx endings of afferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacng2stg/Cacng2stg,Cacng3tm1Ran/Cacng3tm1Ran
Genetic Background: involves: A/J

Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: involves: A/J

Allelic Composition: Cacng2tm1.1Suto/Cacng2tm1.1Suto
Genetic Background: Not Specified

Allelic Composition: Cacng2tm2.1Suto/Cacng2tm2.1Suto
Genetic Background: Not Specified

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: Cacng2tm1Mwa/Cacng2tm1Mwa,Cacng7tm1Mwa/Cacng7tm1Mwa
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: B6.129-Cacng4tm1Frk

Allelic Composition: Cacng2stg/Cacng2stg,Cacng3tm1Ran/Cacng3tm1Ran
Genetic Background: involves: A/J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cacng4tm1Frk/Cacng4tm1Frk
Genetic Background: B6.129-Cacng4tm1Frk

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+
Genetic Background: CByJ.A-Atp2b2dfw-2J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / complex
 ENSMUSG00000067242 Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*  / complex / reaction
 ENSMUSG00000034656 P97445 / Cacna1a / Voltage-dependent P/Q-type calcium channel subunit alpha-1A / O00555* / calcium voltage-gated channel subunit alpha1 A*  / complex
 ENSMUSG00000004113 O55017 / Cacna1b / Voltage-dependent N-type calcium channel subunit alpha-1B / Q00975* / calcium voltage-gated channel subunit alpha1 B*  / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000025964 Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*  / reaction / complex
 ENSMUSG00000003352 Cacnb3 / P54285 / Mus musculus calcium channel, voltage-dependent, beta 3 subunit (Cacnb3), transcript variant 4, mRNA. / P54284* / calcium voltage-gated channel auxiliary subunit beta 3*  / complex
 ENSMUSG00000040537 Adam22 / Q9R1V6 / Disintegrin and metalloproteinase domain-containing protein 22 / Q9P0K1* / ADAM metallopeptidase domain 22*  / complex
 ENSMUSG00000017412 Cacnb4 / Q8R0S4 / Mus musculus calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), transcript variant 6, mRNA. / O00305* / AC068547.1* / calcium voltage-gated channel auxiliary sub...  / complex






 

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