ENSMUSG00000003352


Mus musculus

Features
Gene ID: ENSMUSG00000003352
  
Biological name :Cacnb3
  
Synonyms : Cacnb3 / Mus musculus calcium channel, voltage-dependent, beta 3 subunit (Cacnb3), transcript variant 4, mRNA. / P54285
  
Possible biological names infered from orthology : calcium voltage-gated channel auxiliary subunit beta 3 / P54284
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 98630840
Gene end: 98644529
  
Corresponding Affymetrix probe sets: 10426611 (MoGene1.0st)   1448656_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003442
Ensembl peptide - ENSMUSP00000104778
Ensembl peptide - ENSMUSP00000155514
NCBI entrez gene - 12297     See in Manteia.
MGI - MGI:103307
RefSeq - XM_017316419
RefSeq - NM_001044741
RefSeq - NM_001286226
RefSeq - NM_001356543
RefSeq - NM_007581
RefSeq - XM_006520367
RefSeq - XM_006520370
RefSeq - XM_017316415
RefSeq - XM_017316416
RefSeq - XM_017316417
RefSeq - XM_017316418
RefSeq - XM_006520360
RefSeq - XM_006520361
RefSeq - XM_006520362
RefSeq - XM_006520363
RefSeq - XM_006520364
RefSeq - XM_006520365
RefSeq Peptide - NP_001038206
RefSeq Peptide - NP_001273155
RefSeq Peptide - NP_001343472
RefSeq Peptide - NP_031607
swissprot - P54285
swissprot - D3Z3Z3
Ensembl - ENSMUSG00000003352
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacnb3aENSDARG00000001881Danio rerio
 cacnb3bENSDARG00000076030Danio rerio
 CACNB3ENSG00000167535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacnb4 / Q8R0S4 / Mus musculus calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), transcript variant 6, mRNA. / O00305* / AC068547.1* / calcium voltage-gated channel auxiliary sub...ENSMUSG0000001741265
Cacnb2 / Q8CC27 / Voltage-dependent L-type calcium channel subunit beta-2 / Q08289* / calcium voltage-gated channel auxiliary subunit beta 2*ENSMUSG0000005791463
Cacnb1 / Q8R3Z5 / Voltage-dependent L-type calcium channel subunit beta-1 / Q02641* / calcium voltage-gated channel auxiliary subunit beta 1*ENSMUSG0000002088260


Protein motifs (from Interpro)
Interpro ID Name
 IPR000584  Voltage-dependent calcium channel, L-type, beta subunit
 IPR008079  Voltage-dependent calcium channel, L-type, beta-3 subunit
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035760  Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007528 neuromuscular junction development IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0060402 calcium ion transport into cytosol IDA
 biological_processGO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel IDA
 biological_processGO:0070588 calcium ion transmembrane transport IDA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0098903 regulation of membrane repolarization during action potential IDA
 biological_processGO:1901385 regulation of voltage-gated calcium channel activity IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:1990454 L-type voltage-gated calcium channel complex IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IMP
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IDA
 molecular_functionGO:0019901 protein kinase binding IDA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

 MP:0002802 abnormal discrimination learning "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002975 vascular smooth muscle hypertrophy "increase in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

 MP:0003234 enhanced NMDA-mediated synaptic currents "increase in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Lilrb4atm1Eol/Lilrb4atm1Eol
Genetic Background: B6.129P2-Lilrb4atm1Eol

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004267 abnormal optic tract morphology "any structural anomaly of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il6sttm2Thir/Il6sttm2Thir
Genetic Background: B6.Cg-Il6sttm2Thir

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004113 O55017 / Cacna1b / Voltage-dependent N-type calcium channel subunit alpha-1B / Q00975* / calcium voltage-gated channel subunit alpha1 B*  / complex
 ENSMUSG00000041460 Cacna2d4 / voltage-dependent calcium channel subunit alpha-2/delta-4 isoform 2 / Q7Z3S7* / calcium voltage-gated channel auxiliary subunit alpha2delta 4*  / complex
 ENSMUSG00000010066 Q6PHS9 / Cacna2d2 / Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 / Q9NY47*...  / complex
 ENSMUSG00000019146 Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit / Q9Y698* / calcium voltage-gated channel auxiliary subunit gamma 2*  / complex
 ENSMUSG00000051331 Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*  / complex
 ENSMUSG00000015968 Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*  / complex
 ENSMUSG00000026407 Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*  / complex






 

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