ENSG00000167535


Homo sapiens

Features
Gene ID: ENSG00000167535
  
Biological name :CACNB3
  
Synonyms : CACNB3 / calcium voltage-gated channel auxiliary subunit beta 3 / P54284
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.12
Gene start: 48813794
Gene end: 48828941
  
Corresponding Affymetrix probe sets: 209530_at (Human Genome U133 Plus 2.0 Array)   34726_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449497
Ensembl peptide - ENSP00000448304
Ensembl peptide - ENSP00000449389
Ensembl peptide - ENSP00000301050
Ensembl peptide - ENSP00000444160
Ensembl peptide - ENSP00000445495
Ensembl peptide - ENSP00000446529
Ensembl peptide - ENSP00000446611
Ensembl peptide - ENSP00000447261
Ensembl peptide - ENSP00000447462
Ensembl peptide - ENSP00000448074
Ensembl peptide - ENSP00000448076
Ensembl peptide - ENSP00000448137
NCBI entrez gene - 784     See in Manteia.
OMIM - 601958
RefSeq - XM_017019959
RefSeq - NM_000725
RefSeq - NM_001206915
RefSeq - NM_001206916
RefSeq - NM_001206917
RefSeq - XM_011538727
RefSeq - XM_011538728
RefSeq - XM_017019957
RefSeq - XM_017019958
RefSeq Peptide - NP_000716
RefSeq Peptide - NP_001193844
RefSeq Peptide - NP_001193846
RefSeq Peptide - NP_001193845
swissprot - F8VUW8
swissprot - F8VV14
swissprot - F8VWK1
swissprot - F8W0F8
swissprot - F8W1N3
swissprot - H0YHK1
swissprot - H0YHY2
swissprot - P54284
swissprot - F8VNV8
swissprot - F8VU10
Ensembl - ENSG00000167535
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacnb3aENSDARG00000001881Danio rerio
 cacnb3bENSDARG00000076030Danio rerio
 Cacnb3ENSMUSG00000003352Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CACNB4 / O00305 / calcium voltage-gated channel auxiliary subunit beta 4ENSG0000018238965
CACNB2 / Q08289 / calcium voltage-gated channel auxiliary subunit beta 2ENSG0000016599563
CACNB1 / Q02641 / calcium voltage-gated channel auxiliary subunit beta 1ENSG0000006719161
AC068547.1ENSG0000028322829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000584  Voltage-dependent calcium channel, L-type, beta subunit
 IPR008079  Voltage-dependent calcium channel, L-type, beta-3 subunit
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035760  Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007528 neuromuscular junction development IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051899 membrane depolarization TAS
 biological_processGO:0060402 calcium ion transport into cytosol ISS
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel ISS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0072659 protein localization to plasma membrane ISS
 biological_processGO:0098903 regulation of membrane repolarization during action potential ISS
 biological_processGO:1901385 regulation of voltage-gated calcium channel activity IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:1990454 L-type voltage-gated calcium channel complex ISS
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity ISS
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Adrenaline,noradrenaline inhibits insulin secretion
NCAM1 interactions
Regulation of insulin secretion
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000007402 Q9NY47 / CACNA2D2 / calcium voltage-gated channel auxiliary subunit alpha2delta 2  / complex
 ENSG00000151062 Q7Z3S7 / CACNA2D4 / calcium voltage-gated channel auxiliary subunit alpha2delta 4  / complex
 ENSG00000157388 Q01668 / CACNA1D / calcium voltage-gated channel subunit alpha1 D  / complex
 ENSG00000148408 Q00975 / CACNA1B / calcium voltage-gated channel subunit alpha1 B  / complex
 ENSG00000166862 CACNG2 / Q9Y698 / calcium voltage-gated channel auxiliary subunit gamma 2  / complex
 ENSG00000157445 Q8IZS8 / CACNA2D3 / calcium voltage-gated channel auxiliary subunit alpha2delta 3  / complex
 ENSG00000151067 Q13936 / CACNA1C / calcium voltage-gated channel subunit alpha1 C  / complex
 ENSG00000102001 O60840 / CACNA1F / calcium voltage-gated channel subunit alpha1 F  / complex
 ENSG00000153956 P54289 / CACNA2D1 / calcium voltage-gated channel auxiliary subunit alpha2delta 1  / complex
 ENSG00000081248 Q13698 / CACNA1S / calcium voltage-gated channel subunit alpha1 S  / complex






 

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