ENSG00000157445


Homo sapiens

Features
Gene ID: ENSG00000157445
  
Biological name :CACNA2D3
  
Synonyms : CACNA2D3 / calcium voltage-gated channel auxiliary subunit alpha2delta 3 / Q8IZS8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.1
Gene start: 54122547
Gene end: 55074557
  
Corresponding Affymetrix probe sets: 219714_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418228
Ensembl peptide - ENSP00000418028
Ensembl peptide - ENSP00000419101
Ensembl peptide - ENSP00000478969
Ensembl peptide - ENSP00000288197
Ensembl peptide - ENSP00000389506
Ensembl peptide - ENSP00000417279
Ensembl peptide - ENSP00000417318
Ensembl peptide - ENSP00000417455
NCBI entrez gene - 55799     See in Manteia.
OMIM - 606399
RefSeq - XM_017006854
RefSeq - XM_011533954
RefSeq - XM_017006850
RefSeq - XM_017006851
RefSeq - XM_017006852
RefSeq - XM_017006853
RefSeq - NM_018398
RefSeq - XM_005265318
RefSeq - XM_011533946
RefSeq - XM_011533947
RefSeq - XM_011533948
RefSeq - XM_011533949
RefSeq - XM_011533950
RefSeq - XM_011533951
RefSeq - XM_011533952
RefSeq - XM_011533953
RefSeq Peptide - NP_060868
swissprot - C9JAV5
swissprot - F8WAV4
swissprot - B4DSF6
swissprot - Q8IZS8
Ensembl - ENSG00000157445
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7Z3S7 / CACNA2D4 / calcium voltage-gated channel auxiliary subunit alpha2delta 4ENSG0000015106259
Q9NY47 / CACNA2D2 / calcium voltage-gated channel auxiliary subunit alpha2delta 2ENSG0000000740228
P54289 / CACNA2D1 / calcium voltage-gated channel auxiliary subunit alpha2delta 1ENSG0000015395628
CACHD1 / cache domain containing 1ENSG0000015896619


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR013608  VWA N-terminal
 IPR013680  Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
 IPR033479  Double Cache domain 1
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157388 Q01668 / CACNA1D / calcium voltage-gated channel subunit alpha1 D  / complex
 ENSG00000081248 Q13698 / CACNA1S / calcium voltage-gated channel subunit alpha1 S  / complex
 ENSG00000182389 CACNB4 / O00305 / calcium voltage-gated channel auxiliary subunit beta 4  / complex
 ENSG00000167535 CACNB3 / P54284 / calcium voltage-gated channel auxiliary subunit beta 3  / complex
 ENSG00000151067 Q13936 / CACNA1C / calcium voltage-gated channel subunit alpha1 C  / complex
 ENSG00000102001 O60840 / CACNA1F / calcium voltage-gated channel subunit alpha1 F  / complex
 ENSG00000067191 CACNB1 / Q02641 / calcium voltage-gated channel auxiliary subunit beta 1  / complex
 ENSG00000157445 Q8IZS8 / CACNA2D3 / calcium voltage-gated channel auxiliary subunit alpha2delta 3  / complex
 ENSG00000165995 CACNB2 / Q08289 / calcium voltage-gated channel auxiliary subunit beta 2  / complex






 

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