ENSG00000007402


Homo sapiens

Features
Gene ID: ENSG00000007402
  
Biological name :CACNA2D2
  
Synonyms : CACNA2D2 / calcium voltage-gated channel auxiliary subunit alpha2delta 2 / Q9NY47
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 50362799
Gene end: 50504244
  
Corresponding Affymetrix probe sets: 204811_s_at (Human Genome U133 Plus 2.0 Array)   242806_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404631
Ensembl peptide - ENSP00000390329
Ensembl peptide - ENSP00000407393
Ensembl peptide - ENSP00000418081
Ensembl peptide - ENSP00000266039
Ensembl peptide - ENSP00000354228
NCBI entrez gene - 9254     See in Manteia.
OMIM - 607082
RefSeq - XM_011534243
RefSeq - NM_001005505
RefSeq - NM_001174051
RefSeq - NM_001291101
RefSeq - NM_006030
RefSeq - XM_005265581
RefSeq Peptide - NP_001278030
RefSeq Peptide - NP_001167522
RefSeq Peptide - NP_001005505
RefSeq Peptide - NP_006021
swissprot - C9JE82
swissprot - C9JVC9
swissprot - Q9NY47
Ensembl - ENSG00000007402
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna2d2aENSDARG00000103390Danio rerio
 cacna2d2bENSDARG00000078169Danio rerio
 CACNA2D2ENSGALG00000038242Gallus gallus
 Q6PHS9ENSMUSG00000010066Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P54289 / CACNA2D1 / calcium voltage-gated channel auxiliary subunit alpha2delta 1ENSG0000015395652
Q7Z3S7 / CACNA2D4 / calcium voltage-gated channel auxiliary subunit alpha2delta 4ENSG0000015106228
Q8IZS8 / CACNA2D3 / calcium voltage-gated channel auxiliary subunit alpha2delta 3ENSG0000015744527
CACHD1 / cache domain containing 1ENSG0000015896617


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR013608  VWA N-terminal
 IPR013680  Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0046622 positive regulation of organ growth IEA
 biological_processGO:0048747 muscle fiber development IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0060024 rhythmic synaptic transmission IEA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Adrenaline,noradrenaline inhibits insulin secretion
Regulation of insulin secretion
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102001 O60840 / CACNA1F / calcium voltage-gated channel subunit alpha1 F  / complex
 ENSG00000007402 Q9NY47 / CACNA2D2 / calcium voltage-gated channel auxiliary subunit alpha2delta 2  / complex
 ENSG00000167535 CACNB3 / P54284 / calcium voltage-gated channel auxiliary subunit beta 3  / complex
 ENSG00000151067 Q13936 / CACNA1C / calcium voltage-gated channel subunit alpha1 C  / complex
 ENSG00000182389 CACNB4 / O00305 / calcium voltage-gated channel auxiliary subunit beta 4  / complex
 ENSG00000081248 Q13698 / CACNA1S / calcium voltage-gated channel subunit alpha1 S  / complex
 ENSG00000165995 CACNB2 / Q08289 / calcium voltage-gated channel auxiliary subunit beta 2  / complex
 ENSG00000067191 CACNB1 / Q02641 / calcium voltage-gated channel auxiliary subunit beta 1  / complex
 ENSG00000157388 Q01668 / CACNA1D / calcium voltage-gated channel subunit alpha1 D  / complex
 ENSG00000198216 Q15878 / CACNA1E / calcium voltage-gated channel subunit alpha1 E  / complex
 ENSG00000141837 O00555 / CACNA1A / calcium voltage-gated channel subunit alpha1 A  / complex






 

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