ENSG00000067191


Homo sapiens

Features
Gene ID: ENSG00000067191
  
Biological name :CACNB1
  
Synonyms : CACNB1 / calcium voltage-gated channel auxiliary subunit beta 1 / Q02641
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 39173456
Gene end: 39197703
  
Corresponding Affymetrix probe sets: 206996_x_at (Human Genome U133 Plus 2.0 Array)   210185_at (Human Genome U133 Plus 2.0 Array)   210967_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345461
Ensembl peptide - ENSP00000377840
Ensembl peptide - ENSP00000377847
Ensembl peptide - ENSP00000477612
NCBI entrez gene - 782     See in Manteia.
OMIM - 114207
RefSeq - XM_017025030
RefSeq - NM_000723
RefSeq - NM_199247
RefSeq - NM_199248
RefSeq - XM_017025025
RefSeq - XM_017025026
RefSeq - XM_017025027
RefSeq - XM_017025028
RefSeq - XM_017025029
RefSeq - XM_005257645
RefSeq - XM_005257646
RefSeq - XM_006722072
RefSeq - XM_017025024
RefSeq Peptide - NP_954855
RefSeq Peptide - NP_954856
RefSeq Peptide - NP_000714
swissprot - Q02641
swissprot - Q6TME4
Ensembl - ENSG00000067191
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacnb1ENSDARG00000002167Danio rerio
 CACNB1ENSGALG00000025788Gallus gallus
 Cacnb1ENSMUSG00000020882Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CACNB2 / Q08289 / calcium voltage-gated channel auxiliary subunit beta 2ENSG0000016599562
CACNB4 / O00305 / calcium voltage-gated channel auxiliary subunit beta 4ENSG0000018238953
CACNB3 / P54284 / calcium voltage-gated channel auxiliary subunit beta 3ENSG0000016753549
AC068547.1ENSG0000028322823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000584  Voltage-dependent calcium channel, L-type, beta subunit
 IPR001452  SH3 domain
 IPR005443  Voltage-dependent calcium channel, L-type, beta-1 subunit
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007528 neuromuscular junction development IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:1901385 regulation of voltage-gated calcium channel activity IBA
 biological_processGO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IGI
 biological_processGO:1904646 cellular response to amyloid-beta IGI
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IBA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
NCAM1 interactions
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000007402 Q9NY47 / CACNA2D2 / calcium voltage-gated channel auxiliary subunit alpha2delta 2  / complex
 ENSG00000151062 Q7Z3S7 / CACNA2D4 / calcium voltage-gated channel auxiliary subunit alpha2delta 4  / complex
 ENSG00000157388 Q01668 / CACNA1D / calcium voltage-gated channel subunit alpha1 D  / complex
 ENSG00000157445 Q8IZS8 / CACNA2D3 / calcium voltage-gated channel auxiliary subunit alpha2delta 3  / complex
 ENSG00000151067 Q13936 / CACNA1C / calcium voltage-gated channel subunit alpha1 C  / complex
 ENSG00000102001 O60840 / CACNA1F / calcium voltage-gated channel subunit alpha1 F  / complex
 ENSG00000153956 P54289 / CACNA2D1 / calcium voltage-gated channel auxiliary subunit alpha2delta 1  / complex
 ENSG00000081248 Q13698 / CACNA1S / calcium voltage-gated channel subunit alpha1 S  / complex






 

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