ENSDARG00000002167


Danio rerio

Features
Gene ID: ENSDARG00000002167
  
Biological name :cacnb1
  
Synonyms : cacnb1 / calcium channel, voltage-dependent, beta 1 subunit
  
Possible biological names infered from orthology : calcium voltage-gated channel auxiliary subunit beta 1 / Q02641 / Q8R3Z5 / Voltage-dependent L-type calcium channel subunit beta-1
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 16157120
Gene end: 16227683
  
Corresponding Affymetrix probe sets: Dr.15379.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000013850
Ensembl peptide - ENSDARP00000057158
Ensembl peptide - ENSDARP00000098922
Ensembl peptide - ENSDARP00000108239
NCBI entrez gene - 436925     See in Manteia.
RefSeq - NM_001002652
RefSeq Peptide - NP_001002652
swissprot - F1R605
swissprot - Q2Q551
swissprot - Q2Q552
swissprot - Q6DG31
ZFIN ID - ZDB-GENE-040718-399
Ensembl - ENSDARG00000002167
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CACNB1ENSGALG00000025788Gallus gallus
 CACNB1ENSG00000067191Homo sapiens
 Cacnb1ENSMUSG00000020882Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cacnb2a / calcium channel, voltage-dependent, beta 2a / CACNB2* / Q08289* / Q8CC27* / calcium voltage-gated channel auxiliary subunit beta 2* / Voltage-dependent L-type calcium channel subu...ENSDARG0000009904553
cacnb4a / calcium channel, voltage-dependent, beta 4a subunit / O00305* / CACNB4* / Q8R0S4* / AC068547.1* / calcium voltage-gated channel auxiliary subunit beta 4* / Mus musculus calcium ch...ENSDARG0000000973851
cacnb4b / calcium channel, voltage-dependent, beta 4b subunit / O00305* / CACNB4* / Q8R0S4* / AC068547.1* / calcium voltage-gated channel auxiliary subunit beta 4* / Mus musculus calcium ch...ENSDARG0000006217451
cacnb3a / calcium channel, voltage-dependent, beta 3a / P54285* / P54284* / CACNB3* / calcium voltage-gated channel auxiliary subunit beta 3* / Mus musculus calcium channel, voltage-depende...ENSDARG0000000188150
cacnb3b / calcium channel, voltage-dependent, beta 3b / P54285* / P54284* / CACNB3* / calcium voltage-gated channel auxiliary subunit beta 3* / Mus musculus calcium channel, voltage-depende...ENSDARG0000007603046
cacnb2b / calcium channel, voltage-dependent, beta 2b / CACNB2* / Q08289* / Q8CC27* / calcium voltage-gated channel auxiliary subunit beta 2* / Voltage-dependent L-type calcium channel subu...ENSDARG0000005556540


Protein motifs (from Interpro)
Interpro ID Name
 IPR000584  Voltage-dependent calcium channel, L-type, beta subunit
 IPR001452  SH3 domain
 IPR005443  Voltage-dependent calcium channel, L-type, beta-1 subunit
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0070978 voltage-gated calcium channel complex assembly IMP
 cellular_componentGO:0005891 voltage-gated calcium channel complex IDA
 cellular_componentGO:0016020 membrane ISS
 molecular_functionGO:0005245 voltage-gated calcium channel activity IMP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism immobile , abnormal
Show

 ZFA:0005277 skeletal muscle skeletal muscle sarcomere decreased length , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell longitudinal sarcoplasmic reticulum increased amount , abnormal
skeletal muscle cell T-tubule decreased amount , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell myofibril increased length , abnormal
slow muscle cell myofibril decreased width , abnormal
slow muscle cell myofibril disorganized , abnormal
slow muscle cell myofibril undulate , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000029457 cacna1sa / calcium channel, voltage-dependent, L type, alpha 1S subunit, a / Q13698* / CACNA1S* / calcium voltage-gated channel subunit alpha1 S*  / complex
 ENSDARG00000042552 cacna1sb / calcium channel, voltage-dependent, L type, alpha 1S subunit, b / Q13698* / CACNA1S* / calcium voltage-gated channel subunit alpha1 S*  / complex
 ENSDARG00000078169 cacna2d2b / calcium channel, voltage-dependent, alpha 2/delta subunit 2b / Q6PHS9* / Q9NY47* / CACNA2D2* / calcium voltage-gated channel auxiliary subunit alpha2delta 2* / Voltage-dependent...  / complex
 ENSDARG00000103390 cacna2d2a / calcium channel, voltage-dependent, alpha 2/delta subunit 2a / Q9NY47* / CACNA2D2* / calcium voltage-gated channel auxiliary subunit alpha2delta 2*  / complex






 

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