ENSDARG00000029457


Danio rerio

Features
Gene ID: ENSDARG00000029457
  
Biological name :cacna1sa
  
Synonyms : cacna1sa / calcium channel, voltage-dependent, L type, alpha 1S subunit, a
  
Possible biological names infered from orthology : CACNA1S / calcium voltage-gated channel subunit alpha1 S / Q13698
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 912450
Gene end: 968484
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000096673
NCBI entrez gene - 570683     See in Manteia.
RefSeq - NM_001146150
RefSeq - XM_005168275
RefSeq Peptide - NP_001139622
swissprot - C0LU14
ZFIN ID - ZDB-GENE-090514-1
Ensembl - ENSDARG00000029457
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CACNA1SENSGALG00000037744Gallus gallus
 Q13698ENSG00000081248Homo sapiens
 Cacna1sENSMUSG00000026407Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cacna1sb / calcium channel, voltage-dependent, L type, alpha 1S subunit, b / Q13698* / CACNA1S* / calcium voltage-gated channel subunit alpha1 S*ENSDARG0000004255276
cacna1c / calcium channel, voltage-dependent, L type, alpha 1C subunit / Q01815* / Q13936* / calcium voltage-gated channel subunit alpha1 C* / Voltage-dependent L-type calcium channel subun...ENSDARG0000000839864
cacna1da / calcium channel, voltage-dependent, L type, alpha 1D subunit, a / Q01668* / CACNA1D* / calcium voltage-gated channel subunit alpha1 D*ENSDARG0000010277361
cacna1fb / calcium channel, voltage-dependent, L type, alpha 1F subunit / O60840* / CACNA1F* / calcium voltage-gated channel subunit alpha1 F*ENSDARG0000002368357
cacna1bb / calcium channel, voltage-dependent, N type, alpha 1B subunit, b / O55017* / Q00975* / CACNA1B* / calcium voltage-gated channel subunit alpha1 B* / Voltage-dependent N-type calciu...ENSDARG0000007929540
cacna1ba / calcium channel, voltage-dependent, N type, alpha 1B subunit, a / O55017* / Q00975* / CACNA1B* / calcium voltage-gated channel subunit alpha1 B* / Voltage-dependent N-type calciu...ENSDARG0000002173540
cacna1ab / calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b / O00555* / P97445* / CACNA1A* / calcium voltage-gated channel subunit alpha1 A* / Voltage-dependent P/Q-type ca...ENSDARG0000000692340
cacna1aa / calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a / O00555* / CACNA1A* / calcium voltage-gated channel subunit alpha1 A*ENSDARG0000003790539
cacna1eb / calcium channel, voltage-dependent, R type, alpha 1E subunit b / Q15878* / CACNA1E* / calcium voltage-gated channel subunit alpha1 E*ENSDARG0000009561438
cacna1ea / calcium channel, voltage-dependent, R type, alpha 1E subunit a / Q15878* / CACNA1E* / calcium voltage-gated channel subunit alpha1 E*ENSDARG0000006234629
cacna1fa / calcium channel, voltage-dependent, L type, alpha 1F subunit a / O60840* / CACNA1F* / calcium voltage-gated channel subunit alpha1 F*ENSDARG0000001093321
nalcn / sodium leak channel, non-selective / Q8IZF0*ENSDARG0000000183520
cacna1db / calcium channel, voltage-dependent, L type, alpha 1D subunit, b / Q01668* / CACNA1D* / calcium voltage-gated channel subunit alpha1 D*ENSDARG0000011064215
FO082780.1 / O60840* / CACNA1F* / calcium voltage-gated channel subunit alpha1 F*ENSDARG0000011552812
cacna1db / calcium channel, voltage-dependent, L type, alpha 1D subunit, b / Q01668* / CACNA1D* / calcium voltage-gated channel subunit alpha1 D*ENSDARG0000011560310


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005446  Voltage-dependent calcium channel, L-type, alpha-1 subunit
 IPR005450  Voltage-dependent calcium channel, L-type, alpha-1S subunit
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain
 IPR031688  Voltage-gated calcium channel subunit alpha, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IBA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002167 cacnb1 / calcium channel, voltage-dependent, beta 1 subunit / Q02641* / Q8R3Z5* / calcium voltage-gated channel auxiliary subunit beta 1* / Voltage-dependent L-type calcium channel subunit beta-1 *  / complex
 ENSDARG00000078169 cacna2d2b / calcium channel, voltage-dependent, alpha 2/delta subunit 2b / Q6PHS9* / Q9NY47* / CACNA2D2* / calcium voltage-gated channel auxiliary subunit alpha2delta 2* / Voltage-dependent...  / complex
 ENSDARG00000103390 cacna2d2a / calcium channel, voltage-dependent, alpha 2/delta subunit 2a / Q9NY47* / CACNA2D2* / calcium voltage-gated channel auxiliary subunit alpha2delta 2*  / complex






 

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