ENSDARG00000008398


Danio rerio

Features
Gene ID: ENSDARG00000008398
  
Biological name :cacna1c
  
Synonyms : cacna1c / calcium channel, voltage-dependent, L type, alpha 1C subunit
  
Possible biological names infered from orthology : calcium voltage-gated channel subunit alpha1 C / Q01815 / Q13936 / Voltage-dependent L-type calcium channel subunit alpha-1C
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 20318127
Gene end: 20474972
  
Corresponding Affymetrix probe sets: Dr.12606.1.S1_at (Zebrafish Array)   NM_131900_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000031067
Ensembl peptide - ENSDARP00000116425
NCBI entrez gene - 170581     See in Manteia.
RefSeq - NM_131900
RefSeq Peptide - NP_571975
swissprot - F1R1T3
swissprot - Q5TZF1
ZFIN ID - ZDB-GENE-020129-1
Ensembl - ENSDARG00000008398
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CACNA1CENSGALG00000013022Gallus gallus
 Q13936ENSG00000151067Homo sapiens
 Q01815ENSMUSG00000051331Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cacna1da / calcium channel, voltage-dependent, L type, alpha 1D subunit, a / Q01668* / CACNA1D* / calcium voltage-gated channel subunit alpha1 D*ENSDARG0000010277362
cacna1fb / calcium channel, voltage-dependent, L type, alpha 1F subunit / O60840* / CACNA1F* / calcium voltage-gated channel subunit alpha1 F*ENSDARG0000002368354
cacna1sa / calcium channel, voltage-dependent, L type, alpha 1S subunit, a / Q13698* / CACNA1S* / calcium voltage-gated channel subunit alpha1 S*ENSDARG0000002945752
cacna1sb / calcium channel, voltage-dependent, L type, alpha 1S subunit, b / Q13698* / CACNA1S* / calcium voltage-gated channel subunit alpha1 S*ENSDARG0000004255250
cacna1ab / calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b / O00555* / P97445* / CACNA1A* / calcium voltage-gated channel subunit alpha1 A* / Voltage-dependent P/Q-type ca...ENSDARG0000000692337
cacna1bb / calcium channel, voltage-dependent, N type, alpha 1B subunit, b / O55017* / Q00975* / CACNA1B* / calcium voltage-gated channel subunit alpha1 B* / Voltage-dependent N-type calciu...ENSDARG0000007929536
cacna1ba / calcium channel, voltage-dependent, N type, alpha 1B subunit, a / O55017* / Q00975* / CACNA1B* / calcium voltage-gated channel subunit alpha1 B* / Voltage-dependent N-type calciu...ENSDARG0000002173536
cacna1aa / calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a / O00555* / CACNA1A* / calcium voltage-gated channel subunit alpha1 A*ENSDARG0000003790536
cacna1eb / calcium channel, voltage-dependent, R type, alpha 1E subunit b / Q15878* / CACNA1E* / calcium voltage-gated channel subunit alpha1 E*ENSDARG0000009561434
cacna1ea / calcium channel, voltage-dependent, R type, alpha 1E subunit a / Q15878* / CACNA1E* / calcium voltage-gated channel subunit alpha1 E*ENSDARG0000006234626
cacna1fa / calcium channel, voltage-dependent, L type, alpha 1F subunit a / O60840* / CACNA1F* / calcium voltage-gated channel subunit alpha1 F*ENSDARG0000001093320
nalcn / sodium leak channel, non-selective / Q8IZF0*ENSDARG0000000183517
cacna1db / calcium channel, voltage-dependent, L type, alpha 1D subunit, b / Q01668* / CACNA1D* / calcium voltage-gated channel subunit alpha1 D*ENSDARG0000011064216
FO082780.1 / O60840* / CACNA1F* / calcium voltage-gated channel subunit alpha1 F*ENSDARG000001155289
cacna1db / calcium channel, voltage-dependent, L type, alpha 1D subunit, b / Q01668* / CACNA1D* / calcium voltage-gated channel subunit alpha1 D*ENSDARG000001156038


Protein motifs (from Interpro)
Interpro ID Name
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005446  Voltage-dependent calcium channel, L-type, alpha-1 subunit
 IPR005451  Voltage-dependent calcium channel, L-type, alpha-1C subunit
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain
 IPR031688  Voltage-gated calcium channel subunit alpha, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003301 physiological cardiac muscle hypertrophy IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070509 calcium ion import IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IMP
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IBA


Pathways (from Reactome)
Pathway description
Regulation of insulin secretion
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
brain hydrocephalic , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle non-functional , abnormal
cardiac ventricle morphology , abnormal
cardiac ventricle cardiac muscle cell non-contractile , abnormal
cardiac ventricle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk edematous , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart contractility , abnormal
heart decreased contractility , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct dilated , abnormal
pronephric duct cystic , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage chondrocyte decreased size , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch decreased size , abnormal
Show

 ZFA:0001374 atrial myocardium atrial myocardium contractility , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus unfused from pronephric glomerulus , abnormal
Show

 ZFA:0001673 pronephric podocyte pronephric podocyte unfused from pronephric podocyte , abnormal
Show

 ZFA:0005061 ventricular myocardium ventricular myocardium decreased thickness , abnormal
ventricular myocardium non-functional , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased volume , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr