ENSMUSG00000020882


Mus musculus

Features
Gene ID: ENSMUSG00000020882
  
Biological name :Cacnb1
  
Synonyms : Cacnb1 / Q8R3Z5 / Voltage-dependent L-type calcium channel subunit beta-1
  
Possible biological names infered from orthology : calcium voltage-gated channel auxiliary subunit beta 1 / Q02641
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 98001508
Gene end: 98023034
  
Corresponding Affymetrix probe sets: 10390542 (MoGene1.0st)   1425777_at (Mouse Genome 430 2.0 Array)   1426108_s_at (Mouse Genome 430 2.0 Array)   1440940_at (Mouse Genome 430 2.0 Array)   1451834_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103187
Ensembl peptide - ENSMUSP00000017552
Ensembl peptide - ENSMUSP00000090412
Ensembl peptide - ENSMUSP00000099433
Ensembl peptide - ENSMUSP00000103186
NCBI entrez gene - 12295     See in Manteia.
MGI - MGI:102522
RefSeq - XM_017314236
RefSeq - NM_001159319
RefSeq - NM_001159320
RefSeq - NM_001282977
RefSeq - NM_001282978
RefSeq - NM_031173
RefSeq - NM_145121
RefSeq - XM_006532091
RefSeq - XM_006532092
RefSeq - XM_006532094
RefSeq Peptide - NP_001152791
RefSeq Peptide - NP_001152792
RefSeq Peptide - NP_001269906
RefSeq Peptide - NP_001269907
RefSeq Peptide - NP_112450
RefSeq Peptide - NP_660099
swissprot - A0A0R4J194
swissprot - A2A545
swissprot - A2A543
swissprot - A2A542
swissprot - Q8R3Z5
Ensembl - ENSMUSG00000020882
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacnb1ENSDARG00000002167Danio rerio
 CACNB1ENSGALG00000025788Gallus gallus
 CACNB1ENSG00000067191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacnb2 / Q8CC27 / Voltage-dependent L-type calcium channel subunit beta-2 / Q08289* / calcium voltage-gated channel auxiliary subunit beta 2*ENSMUSG0000005791462
Cacnb4 / Q8R0S4 / Mus musculus calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), transcript variant 6, mRNA. / O00305* / AC068547.1* / calcium voltage-gated channel auxiliary sub...ENSMUSG0000001741253
Cacnb3 / P54285 / Mus musculus calcium channel, voltage-dependent, beta 3 subunit (Cacnb3), transcript variant 4, mRNA. / P54284* / calcium voltage-gated channel auxiliary subunit beta 3*ENSMUSG0000000335249


Protein motifs (from Interpro)
Interpro ID Name
 IPR000584  Voltage-dependent calcium channel, L-type, beta subunit
 IPR001452  SH3 domain
 IPR005443  Voltage-dependent calcium channel, L-type, beta-1 subunit
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006612 protein targeting to membrane IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007528 neuromuscular junction development IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:1901385 regulation of voltage-gated calcium channel activity IBA
 biological_processGO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
 biological_processGO:1904646 cellular response to amyloid-beta ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 cellular_componentGO:0030315 T-tubule IDA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IGI


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010066 Q6PHS9 / Cacna2d2 / Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 / Q9NY47*...  / complex
 ENSMUSG00000041460 Cacna2d4 / voltage-dependent calcium channel subunit alpha-2/delta-4 isoform 2 / Q7Z3S7* / calcium voltage-gated channel auxiliary subunit alpha2delta 4*  / complex
 ENSMUSG00000051331 Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*  / complex
 ENSMUSG00000015968 Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*  / complex
 ENSMUSG00000026407 Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*  / complex






 

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