ENSMUSG00000057914


Mus musculus

Features
Gene ID: ENSMUSG00000057914
  
Biological name :Cacnb2
  
Synonyms : Cacnb2 / Q8CC27 / Voltage-dependent L-type calcium channel subunit beta-2
  
Possible biological names infered from orthology : calcium voltage-gated channel auxiliary subunit beta 2 / Q08289
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A2
Gene start: 14603088
Gene end: 14987908
  
Corresponding Affymetrix probe sets: 10469404 (MoGene1.0st)   1452476_at (Mouse Genome 430 2.0 Array)   1456401_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142281
Ensembl peptide - ENSMUSP00000110371
Ensembl peptide - ENSMUSP00000141221
Ensembl peptide - ENSMUSP00000141742
Ensembl peptide - ENSMUSP00000110367
NCBI entrez gene - 12296     See in Manteia.
MGI - MGI:894644
RefSeq - XM_011238946
RefSeq - XM_006497314
RefSeq - XM_006497315
RefSeq - XM_006497317
RefSeq - XM_006497318
RefSeq - XM_006497319
RefSeq - XM_006497320
RefSeq - XM_006497321
RefSeq - XM_006497323
RefSeq - NM_001252533
RefSeq - NM_001309519
RefSeq - NM_023116
RefSeq - XM_006497313
RefSeq Peptide - NP_001239462
RefSeq Peptide - NP_001296448
RefSeq Peptide - NP_075605
swissprot - Q8CC27
swissprot - C7IVS7
swissprot - A0A0A6YWX5
swissprot - A0A0A6YY52
swissprot - Q32MF3
Ensembl - ENSMUSG00000057914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacnb2aENSDARG00000099045Danio rerio
 cacnb2bENSDARG00000055565Danio rerio
 CACNB2ENSGALG00000008591Gallus gallus
 CACNB2ENSG00000165995Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacnb1 / Q8R3Z5 / Voltage-dependent L-type calcium channel subunit beta-1 / Q02641* / calcium voltage-gated channel auxiliary subunit beta 1*ENSMUSG0000002088256
Cacnb4 / Q8R0S4 / Mus musculus calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), transcript variant 6, mRNA. / O00305* / AC068547.1* / calcium voltage-gated channel auxiliary sub...ENSMUSG0000001741252
Cacnb3 / P54285 / Mus musculus calcium channel, voltage-dependent, beta 3 subunit (Cacnb3), transcript variant 4, mRNA. / P54284* / calcium voltage-gated channel auxiliary subunit beta 3*ENSMUSG0000000335246


Protein motifs (from Interpro)
Interpro ID Name
 IPR000584  Voltage-dependent calcium channel, L-type, beta subunit
 IPR001452  SH3 domain
 IPR005444  Voltage-dependent calcium channel, L-type, beta-2 subunit
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035605  CACNB2, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007528 neuromuscular junction development IBA
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051928 positive regulation of calcium ion transport ISO
 biological_processGO:0070509 calcium ion import ISO
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0072659 protein localization to plasma membrane ISS
 biological_processGO:0086045 membrane depolarization during AV node cell action potential ISO
 biological_processGO:0086091 regulation of heart rate by cardiac conduction ISS
 biological_processGO:0098912 membrane depolarization during atrial cardiac muscle cell action potential ISO
 biological_processGO:1901385 regulation of voltage-gated calcium channel activity IBA
 biological_processGO:1901843 positive regulation of high voltage-gated calcium channel activity ISS
 biological_processGO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:1990454 L-type voltage-gated calcium channel complex ISS
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008331 high voltage-gated calcium channel activity TAS
 molecular_functionGO:0051015 actin filament binding IDA
 molecular_functionGO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential ISO
 molecular_functionGO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential ISO


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

Allelic Composition: Cacnb2tm1Rgg/Cacnb2tm1Rgg
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0001889 delayed brain development "the delay or slower progress of the growth and differentiation of the brain" [J:81818, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

 MP:0008520 disorganized retinal outer plexiform layer "a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cacnb2tm1Rgg/Cacnb2tm1Rgg
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

 MP:0012718 decreased hemangioblast number "reduced number of the pluripotent precursor cells in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells; hemangioblasts are the progenitors that form the blood islands" [CL:0002418, MGI:anna]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

 MP:0030313 abnormal face development "any anomaly in the process in which the anatomical structures of the face are generated and organized" [GO:0060325]
Show

Allelic Composition: MitfMi-wh/MitfMi-wh
Genetic Background: B6.Cg-MitfMi-wh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000051331 Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*  / complex
 ENSMUSG00000010066 Q6PHS9 / Cacna2d2 / Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 / Q9NY47*...  / complex
 ENSMUSG00000041460 Cacna2d4 / voltage-dependent calcium channel subunit alpha-2/delta-4 isoform 2 / Q7Z3S7* / calcium voltage-gated channel auxiliary subunit alpha2delta 4*  / complex
 ENSMUSG00000015968 Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*  / complex
 ENSMUSG00000026407 Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*  / complex






 

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