ENSMUSG00000041460


Mus musculus

Features
Gene ID: ENSMUSG00000041460
  
Biological name :Cacna2d4
  
Synonyms : Cacna2d4 / voltage-dependent calcium channel subunit alpha-2/delta-4 isoform 2
  
Possible biological names infered from orthology : calcium voltage-gated channel auxiliary subunit alpha2delta 4 / Q7Z3S7
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F1
Gene start: 119236526
Gene end: 119352407
  
Corresponding Affymetrix probe sets: 10541144 (MoGene1.0st)   1441084_at (Mouse Genome 430 2.0 Array)   1442863_at (Mouse Genome 430 2.0 Array)   1457703_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140197
Ensembl peptide - ENSMUSP00000044660
NCBI entrez gene - 319734     See in Manteia.
MGI - MGI:2442632
RefSeq - NM_001033382
RefSeq - XM_006506251
RefSeq Peptide - NP_001028554
RefSeq Peptide - NP_001334356
swissprot - F8VPL1
swissprot - A0A087WQH4
Ensembl - ENSMUSG00000041460
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna2d4bENSDARG00000023886Danio rerio
 Q7Z3S7ENSG00000151062Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z1L5 / Cacna2d3 / Voltage-dependent calcium channel subunit alpha-2/delta-3 Voltage-dependent calcium channel subunit alpha-2-3 Voltage-dependent calcium channel subunit delta-3ENSMUSG0000002199156
Q6PHS9 / Cacna2d2 / Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 / Q9NY47*...ENSMUSG0000001006628
O08532 / Cacna2d1 / Voltage-dependent calcium channel subunit alpha-2/delta-1 Voltage-dependent calcium channel subunit alpha-2-1 Voltage-dependent calcium channel subunit delta-1 / P54289*...ENSMUSG0000004011826
Cachd1 / Q6PDJ1 / VWFA and cache domain-containing protein 1 / cache domain containing 1*ENSMUSG0000002853218


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR013608  VWA N-terminal
 IPR013680  Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0050908 detection of light stimulus involved in visual perception IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Cacna2d4lob/Cacna2d4lob
Genetic Background: involves: A/J * C57BL/10

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Cacna2d4lob/Cacna2d4lob
Genetic Background: involves: A/J * C57BL/10

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk8tm1Flv/Mapk8tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Cacna2d4lob/Cacna2d4lob
Genetic Background: involves: A/J * C57BL/10

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003352 Cacnb3 / P54285 / Mus musculus calcium channel, voltage-dependent, beta 3 subunit (Cacnb3), transcript variant 4, mRNA. / P54284* / calcium voltage-gated channel auxiliary subunit beta 3*  / complex
 ENSMUSG00000020882 Cacnb1 / Q8R3Z5 / Voltage-dependent L-type calcium channel subunit beta-1 / Q02641* / calcium voltage-gated channel auxiliary subunit beta 1*  / complex
 ENSMUSG00000041460 Cacna2d4 / voltage-dependent calcium channel subunit alpha-2/delta-4 isoform 2 / Q7Z3S7* / calcium voltage-gated channel auxiliary subunit alpha2delta 4*  / complex
 ENSMUSG00000017412 Cacnb4 / Q8R0S4 / Mus musculus calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), transcript variant 6, mRNA. / O00305* / AC068547.1* / calcium voltage-gated channel auxiliary sub...  / complex
 ENSMUSG00000051331 Q01815 / Cacna1c / Voltage-dependent L-type calcium channel subunit alpha-1C / Q13936* / calcium voltage-gated channel subunit alpha1 C*  / complex
 ENSMUSG00000057914 Cacnb2 / Q8CC27 / Voltage-dependent L-type calcium channel subunit beta-2 / Q08289* / calcium voltage-gated channel auxiliary subunit beta 2*  / complex
 ENSMUSG00000015968 Q99246 / Cacna1d / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / calcium voltage-gated channel subunit alpha1 D*  / complex
 ENSMUSG00000026407 Cacna1s / calcium voltage-gated channel subunit alpha1 S / Q13698*  / complex






 

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