ENSMUSG00000021991


Mus musculus

Features
Gene ID: ENSMUSG00000021991
  
Biological name :Cacna2d3
  
Synonyms : Cacna2d3 / Q9Z1L5 / Voltage-dependent calcium channel subunit alpha-2/delta-3 Voltage-dependent calcium channel subunit alpha-2-3 Voltage-dependent calcium channel subunit delta-3
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A3
Gene start: 28904943
Gene end: 29721864
  
Corresponding Affymetrix probe sets: 10418300 (MoGene1.0st)   1419225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022567
Ensembl peptide - ENSMUSP00000153444
Ensembl peptide - ENSMUSP00000153143
Ensembl peptide - ENSMUSP00000153037
Ensembl peptide - ENSMUSP00000152967
NCBI entrez gene - 12294     See in Manteia.
MGI - MGI:1338890
RefSeq - XM_011244938
RefSeq - NM_009785
RefSeq - XM_006518486
RefSeq Peptide - NP_033915
swissprot - A0A286YCT5
swissprot - A0A286YE06
swissprot - Q9Z1L5
swissprot - A0A286YCK6
swissprot - A0A286YCF6
Ensembl - ENSMUSG00000021991
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacna2d4 / voltage-dependent calcium channel subunit alpha-2/delta-4 isoform 2 / Q7Z3S7* / calcium voltage-gated channel auxiliary subunit alpha2delta 4*ENSMUSG0000004146058
Q6PHS9 / Cacna2d2 / Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 / Q9NY47*...ENSMUSG0000001006629
O08532 / Cacna2d1 / Voltage-dependent calcium channel subunit alpha-2/delta-1 Voltage-dependent calcium channel subunit alpha-2-1 Voltage-dependent calcium channel subunit delta-1 / P54289*...ENSMUSG0000004011828
Cachd1 / Q6PDJ1 / VWFA and cache domain-containing protein 1 / cache domain containing 1*ENSMUSG0000002853219


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR013608  VWA N-terminal
 IPR013680  Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Celsr2tm1Dgen/Celsr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Celsr2tm1Dgen/Celsr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0005655 increased aggression "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Celsr2tm1Dgen/Celsr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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