ENSG00000198216


Homo sapiens

Features
Gene ID: ENSG00000198216
  
Biological name :CACNA1E
  
Synonyms : CACNA1E / calcium voltage-gated channel subunit alpha1 E / Q15878
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.3
Gene start: 181317690
Gene end: 181808084
  
Corresponding Affymetrix probe sets: 208432_s_at (Human Genome U133 Plus 2.0 Array)   236013_at (Human Genome U133 Plus 2.0 Array)   238747_at (Human Genome U133 Plus 2.0 Array)   240650_at (Human Genome U133 Plus 2.0 Array)   242410_s_at (Human Genome U133 Plus 2.0 Array)   244256_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000483914
Ensembl peptide - ENSP00000481619
Ensembl peptide - ENSP00000496576
Ensembl peptide - ENSP00000350183
Ensembl peptide - ENSP00000351101
Ensembl peptide - ENSP00000353222
Ensembl peptide - ENSP00000356539
Ensembl peptide - ENSP00000356542
Ensembl peptide - ENSP00000356545
Ensembl peptide - ENSP00000432038
NCBI entrez gene - 777     See in Manteia.
OMIM - 601013
RefSeq - XM_017002251
RefSeq - XM_017002244
RefSeq - XM_017002245
RefSeq - XM_017002246
RefSeq - XM_017002247
RefSeq - XM_017002248
RefSeq - XM_017002249
RefSeq - XM_017002250
RefSeq - NM_000721
RefSeq - NM_001205293
RefSeq - NM_001205294
RefSeq - XM_017002243
RefSeq Peptide - NP_001192223
RefSeq Peptide - NP_000712
RefSeq Peptide - NP_001192222
swissprot - E9PIE8
swissprot - Q15878
swissprot - J3KP11
swissprot - F8W9Z1
Ensembl - ENSG00000198216
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna1eaENSDARG00000062346Danio rerio
 cacna1ebENSDARG00000095614Danio rerio
 CACNA1EENSGALG00000003833Gallus gallus
 Cacna1eENSMUSG00000004110Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O00555 / CACNA1A / calcium voltage-gated channel subunit alpha1 AENSG0000014183759
Q00975 / CACNA1B / calcium voltage-gated channel subunit alpha1 BENSG0000014840856
Q13936 / CACNA1C / calcium voltage-gated channel subunit alpha1 CENSG0000015106735
Q01668 / CACNA1D / calcium voltage-gated channel subunit alpha1 DENSG0000015738834
Q13698 / CACNA1S / calcium voltage-gated channel subunit alpha1 SENSG0000008124833
O60840 / CACNA1F / calcium voltage-gated channel subunit alpha1 FENSG0000010200133
NALCN / Q8IZF0 / sodium leak channel, non-selectiveENSG0000010245216
Q8NEC5 / CATSPER1 / cation channel sperm associated 1ENSG000001752947


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005449  Voltage-dependent calcium channel, R-type, alpha-1 subunit
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0051899 membrane depolarization TAS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005891 voltage-gated calcium channel complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IDA
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000075461 CACNG4 / Q9UBN1 / calcium voltage-gated channel auxiliary subunit gamma 4  / complex
 ENSG00000007402 Q9NY47 / CACNA2D2 / calcium voltage-gated channel auxiliary subunit alpha2delta 2  / complex






 

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