ENSG00000075461


Homo sapiens

Features
Gene ID: ENSG00000075461
  
Biological name :CACNG4
  
Synonyms : CACNG4 / calcium voltage-gated channel auxiliary subunit gamma 4 / Q9UBN1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q24.2
Gene start: 66964910
Gene end: 67033398
  
Corresponding Affymetrix probe sets: 221585_at (Human Genome U133 Plus 2.0 Array)   231737_at (Human Genome U133 Plus 2.0 Array)   62987_r_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262138
NCBI entrez gene - 27092     See in Manteia.
OMIM - 606404
RefSeq - NM_014405
RefSeq Peptide - NP_055220
swissprot - A0A024R8J8
swissprot - Q9UBN1
Ensembl - ENSG00000075461
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacng4aENSDARG00000115540Danio rerio
 cacng4bENSDARG00000074669Danio rerio
 CACNG4ENSGALG00000026091Gallus gallus
 Cacng4ENSMUSG00000020723Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CACNG8 / Q8WXS5 / calcium voltage-gated channel auxiliary subunit gamma 8ENSG0000014240862
CACNG2 / Q9Y698 / calcium voltage-gated channel auxiliary subunit gamma 2ENSG0000016686259
CACNG3 / O60359 / calcium voltage-gated channel auxiliary subunit gamma 3ENSG0000000611657
CACNG5 / Q9UF02 / calcium voltage-gated channel auxiliary subunit gamma 5ENSG0000007542924
CACNG7 / P62955 / calcium voltage-gated channel auxiliary subunit gamma 7ENSG0000010560524


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR005423  Voltage-dependent calcium channel, gamma-4 subunit
 IPR008368  Voltage-dependent calcium channel, gamma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0019226 transmission of nerve impulse IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051899 membrane depolarization TAS
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0070588 calcium ion transmembrane transport IBA
 biological_processGO:2000311 regulation of AMPA receptor activity IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0032281 AMPA glutamate receptor complex ISS
 cellular_componentGO:0036477 somatodendritic compartment IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity TAS
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0016247 channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Trafficking of AMPA receptors
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008277 ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22  / complex
 ENSG00000114948 ADAM23 / O75077 / ADAM metallopeptidase domain 23  / complex / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex
 ENSG00000198216 Q15878 / CACNA1E / calcium voltage-gated channel subunit alpha1 E  / complex
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / complex
 ENSG00000108231 LGI1 / O95970 / leucine rich glioma inactivated 1  / reaction / complex






 

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