ENSG00000132535


Homo sapiens

Features
Gene ID: ENSG00000132535
  
Biological name :DLG4
  
Synonyms : discs large MAGUK scaffold protein 4 / DLG4 / P78352
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.1
Gene start: 7189890
Gene end: 7219702
  
Corresponding Affymetrix probe sets: 204592_at (Human Genome U133 Plus 2.0 Array)   210684_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465720
Ensembl peptide - ENSP00000460625
Ensembl peptide - ENSP00000465789
Ensembl peptide - ENSP00000467897
Ensembl peptide - ENSP00000307471
Ensembl peptide - ENSP00000382425
Ensembl peptide - ENSP00000382428
Ensembl peptide - ENSP00000388122
Ensembl peptide - ENSP00000407918
NCBI entrez gene - 1742     See in Manteia.
OMIM - 602887
RefSeq - XM_017024290
RefSeq - NM_001128827
RefSeq - NM_001321074
RefSeq - NM_001321075
RefSeq - NM_001321076
RefSeq - NM_001321077
RefSeq - NM_001365
RefSeq - XM_005256491
RefSeq - XM_011523698
RefSeq - XM_011523699
RefSeq - XM_011523702
RefSeq - XM_017024288
RefSeq - XM_017024289
RefSeq Peptide - NP_001308003
RefSeq Peptide - NP_001308005
RefSeq Peptide - NP_001308006
RefSeq Peptide - NP_001356
RefSeq Peptide - NP_001122299
RefSeq Peptide - NP_001308004
swissprot - P78352
swissprot - C9JWP9
swissprot - C9JYG3
swissprot - K7EKP9
swissprot - K7EKU8
swissprot - K7EQM6
swissprot - O14909
Ensembl - ENSG00000132535
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlg4aENSDARG00000041926Danio rerio
 Dlg4ENSMUSG00000020886Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DLG1 / Q12959 / discs large MAGUK scaffold protein 1ENSG0000007571173
DLG2 / Q15700 / discs large MAGUK scaffold protein 2ENSG0000015067268
DLG3 / Q92796 / discs large MAGUK scaffold protein 3ENSG0000008245862
DLG5 / Q8TDM6 / discs large MAGUK scaffold protein 5ENSG0000015120824
AL358113.1ENSG0000028513020
TJP2 / Q9UDY2 / tight junction protein 2ENSG0000011913920
MPP5 / Q8N3R9 / membrane palmitoylated protein 5ENSG0000007241520
TJP3 / O95049 / tight junction protein 3ENSG0000010528920
TJP1 / Q07157 / tight junction protein 1ENSG0000010406720
MPP7 / Q5T2T1 / membrane palmitoylated protein 7ENSG0000015005419
MPP6 / Q9NZW5 / membrane palmitoylated protein 6ENSG0000010592619
MPP2 / Q14168 / membrane palmitoylated protein 2ENSG0000010885219
MPP4 / Q96JB8 / membrane palmitoylated protein 4ENSG0000008212618
MPP3 / Q13368 / membrane palmitoylated protein 3ENSG0000016164718
CASK / O14936 / calcium/calmodulin dependent serine protein kinaseENSG0000014704418
MPP1 / Q00013 / membrane palmitoylated protein 1ENSG0000013083015
GUK1 / Q16774 / guanylate kinase 1ENSG000001437749


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR016313  Disks large 1-like
 IPR019583  PDZ-associated domain of NMDA receptors
 IPR019590  Disks large homologue 1, N-terminal PEST domain
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0002091 negative regulation of receptor internalization ISS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007612 learning TAS
 biological_processGO:0016188 synaptic vesicle maturation IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035418 protein localization to synapse IEA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0045184 establishment of protein localization IDA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0050806 positive regulation of synaptic transmission ISS
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0060997 dendritic spine morphogenesis IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity TAS
 biological_processGO:0065003 protein-containing complex assembly IDA
 biological_processGO:0071625 vocalization behavior IEA
 biological_processGO:0097113 AMPA glutamate receptor clustering TAS
 biological_processGO:0097120 receptor localization to synapse IBA
 biological_processGO:0150012 positive regulation of neuron projection arborization ISS
 biological_processGO:2000310 regulation of NMDA receptor activity ISS
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISS
 biological_processGO:2000821 regulation of grooming behavior IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IEA
 cellular_componentGO:0014069 postsynaptic density IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 cellular_componentGO:0030054 cell junction ISS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IEA
 cellular_componentGO:0032839 dendrite cytoplasm ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044224 juxtaparanode region of axon IEA
 cellular_componentGO:0044300 cerebellar mossy fiber IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0044309 neuron spine IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:0097060 synaptic membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0098839 postsynaptic density membrane IEA
 molecular_functionGO:0004385 guanylate kinase activity IBA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0015276 ligand-gated ion channel activity TAS
 molecular_functionGO:0019900 kinase binding IDA
 molecular_functionGO:0019903 protein phosphatase binding ISS
 molecular_functionGO:0030165 PDZ domain binding ISS
 molecular_functionGO:0031697 beta-1 adrenergic receptor binding ISS
 molecular_functionGO:0031748 D1 dopamine receptor binding ISS
 molecular_functionGO:0031812 P2Y1 nucleotide receptor binding ISS
 molecular_functionGO:0033130 acetylcholine receptor binding ISS
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0044877 protein-containing complex binding ISS
 molecular_functionGO:0097109 neuroligin family protein binding ISS
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RHO GTPases activate CIT
RAF/MAP kinase cascade
LGI-ADAM interactions
Neurexins and neuroligins
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006116 CACNG3 / O60359 / calcium voltage-gated channel auxiliary subunit gamma 3  / complex
 ENSG00000033122 LRRC7 / Q96NW7 / leucine rich repeat containing 7  / complex
 ENSG00000128011 LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1  / complex / reaction
 ENSG00000116544 DLGAP3 / O95886 / DLG associated protein 3  / reaction / complex
 ENSG00000075461 CACNG4 / Q9UBN1 / calcium voltage-gated channel auxiliary subunit gamma 4  / complex
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction / complex
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / complex
 ENSG00000122966 CIT / O14578 / citron rho-interacting serine/threonine kinase  / complex / reaction
 ENSG00000113319 O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction / complex
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / complex / reaction
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction / complex
 ENSG00000161681 Q9Y566 / SHANK1 / SH3 and multiple ankyrin repeat domains 1  / complex / reaction
 ENSG00000277586 NEFL / P07196 / neurofilament light  / complex
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / complex
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / complex / reaction
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / complex / reaction
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / reaction / complex
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / complex
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / complex
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / complex
 ENSG00000051128 HOMER3 / Q9NSC5 / homer scaffolding protein 3  / complex / reaction
 ENSG00000091129 NRCAM / Q92823 / neuronal cell adhesion molecule  / reaction / complex
 ENSG00000152413 HOMER1 / Q86YM7 / homer scaffolding protein 1  / reaction / complex
 ENSG00000163110 PDLIM5 / Q96HC4 / PDZ and LIM domain 5  / complex / reaction
 ENSG00000168959 GRM5 / P41594 / glutamate metabotropic receptor 5  / reaction / complex
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / complex / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex
 ENSG00000114948 ADAM23 / O75077 / ADAM metallopeptidase domain 23  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / reaction / complex
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000166862 CACNG2 / Q9Y698 / calcium voltage-gated channel auxiliary subunit gamma 2  / complex
 ENSG00000127914 AKAP9 / Q99996 / A-kinase anchoring protein 9  / complex
 ENSG00000008277 ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22  / complex
 ENSG00000152822 GRM1 / Q13255 / glutamate metabotropic receptor 1  / reaction / complex
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction / complex
 ENSG00000136279 DBNL / Q9UJU6 / drebrin like  / complex / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000149403 GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4  / complex
 ENSG00000142408 CACNG8 / Q8WXS5 / calcium voltage-gated channel auxiliary subunit gamma 8  / complex
 ENSG00000164418 GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2  / complex
 ENSG00000171189 GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1  / complex
 ENSG00000103942 HOMER2 / Q9NSB8 / homer scaffolding protein 2  / complex / reaction
 ENSG00000156564 LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2  / reaction / complex
 ENSG00000163873 GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3  / complex
 ENSG00000173621 LRFN4 / Q6PJG9 / leucine rich repeat and fibronectin type III domain containing 4  / complex / reaction
 ENSG00000170579 DLGAP1 / O14490 / DLG associated protein 1  / complex / reaction
 ENSG00000080845 DLGAP4 / Q9Y2H0 / DLG associated protein 4  / reaction / complex
 ENSG00000162105 Q9UPX8 / SHANK2 / SH3 and multiple ankyrin repeat domains 2  / reaction / complex
 ENSG00000183092 BEGAIN / Q9BUH8 / brain enriched guanylate kinase associated  / complex / reaction
 ENSG00000197555 O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1  / reaction / complex
 ENSG00000108231 LGI1 / O95970 / leucine rich glioma inactivated 1  / reaction / complex
 ENSG00000058335 Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1  / complex / reaction
 ENSG00000198010 DLGAP2 / Q9P1A6 / DLG associated protein 2  / complex / reaction
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction






 

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