ENSG00000058404


Homo sapiens

Features
Gene ID: ENSG00000058404
  
Biological name :CAMK2B
  
Synonyms : calcium/calmodulin dependent protein kinase II beta / CAMK2B / Q13554
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p13
Gene start: 44217150
Gene end: 44334577
  
Corresponding Affymetrix probe sets: 209956_s_at (Human Genome U133 Plus 2.0 Array)   210404_x_at (Human Genome U133 Plus 2.0 Array)   211483_x_at (Human Genome U133 Plus 2.0 Array)   213276_at (Human Genome U133 Plus 2.0 Array)   34846_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390292
Ensembl peptide - ENSP00000388951
Ensembl peptide - ENSP00000390419
Ensembl peptide - ENSP00000428912
Ensembl peptide - ENSP00000410445
Ensembl peptide - ENSP00000400387
Ensembl peptide - ENSP00000397937
Ensembl peptide - ENSP00000258682
Ensembl peptide - ENSP00000326375
Ensembl peptide - ENSP00000326427
Ensembl peptide - ENSP00000326518
Ensembl peptide - ENSP00000326544
Ensembl peptide - ENSP00000326600
Ensembl peptide - ENSP00000351542
Ensembl peptide - ENSP00000379096
Ensembl peptide - ENSP00000379098
Ensembl peptide - ENSP00000388445
NCBI entrez gene - 816     See in Manteia.
OMIM - 607707
RefSeq - XM_017012670
RefSeq - XM_011515552
RefSeq - XM_011515553
RefSeq - XM_011515554
RefSeq - XM_011515555
RefSeq - XM_011515556
RefSeq - XM_011515557
RefSeq - XM_011515558
RefSeq - XM_011515559
RefSeq - XM_017012660
RefSeq - XM_017012661
RefSeq - XM_017012662
RefSeq - XM_017012663
RefSeq - XM_017012664
RefSeq - XM_017012665
RefSeq - XM_017012666
RefSeq - XM_017012667
RefSeq - XM_017012668
RefSeq - XM_017012669
RefSeq - NM_001220
RefSeq - NM_001293170
RefSeq - NM_172078
RefSeq - NM_172079
RefSeq - NM_172080
RefSeq - NM_172081
RefSeq - NM_172082
RefSeq - NM_172083
RefSeq - NM_172084
RefSeq - XM_005249862
RefSeq - XM_005249864
RefSeq - XM_006715781
RefSeq - XM_006715784
RefSeq - XM_011515547
RefSeq - XM_011515549
RefSeq - XM_011515550
RefSeq - XM_011515551
RefSeq Peptide - NP_001280099
RefSeq Peptide - NP_742075
RefSeq Peptide - NP_742076
RefSeq Peptide - NP_742077
RefSeq Peptide - NP_742078
RefSeq Peptide - NP_742079
RefSeq Peptide - NP_742080
RefSeq Peptide - NP_742081
RefSeq Peptide - NP_001211
swissprot - A4D2J9
swissprot - E7ETC9
swissprot - E7ERS6
swissprot - E7EQE4
swissprot - H7BXS4
swissprot - H7BZC6
swissprot - H7C394
swissprot - E9PBE8
swissprot - Q13554
Ensembl - ENSG00000058404
  
Related genetic diseases (OMIM): 617799 - Mental retardation, autosomal dominant 54, 617799
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camk2b1ENSDARG00000011065Danio rerio
 camk2b2ENSDARG00000100089Danio rerio
 ENSGALG00000033061Gallus gallus
 Camk2bENSMUSG00000057897Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gammaENSG0000014866070
CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II deltaENSG0000014534967
CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alphaENSG0000007080862
CAMK1G / Q96NX5 / calcium/calmodulin dependent protein kinase IGENSG0000000811822
CAMK4 / Q16566 / calcium/calmodulin dependent protein kinase IVENSG0000015249521
CAMK1 / Q14012 / calcium/calmodulin dependent protein kinase IENSG0000013407220
PNCK / Q6P2M8 / pregnancy up-regulated nonubiquitous CaM kinaseENSG0000013082220
CAMK1D / Q8IU85 / calcium/calmodulin dependent protein kinase IDENSG0000018304920
CAMKV / Q8NCB2 / CaM kinase like vesicle associatedENSG0000016407619
PSKH1 / P11801 / protein serine kinase H1ENSG0000015979217
PSKH2 / Q96QS6 / protein serine kinase H2ENSG0000014761315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0014733 regulation of skeletal muscle adaptation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity TAS
 biological_processGO:0051823 regulation of synapse structural plasticity TAS
 biological_processGO:0051924 regulation of calcium ion transport TAS
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060998 regulation of dendritic spine development TAS
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis ISS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0090129 positive regulation of synapse maturation ISS
 biological_processGO:1900034 regulation of cellular response to heat TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Interferon gamma signaling
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000033122 LRRC7 / Q96NW7 / leucine rich repeat containing 7  / reaction / complex
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction / complex
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / reaction / complex
 ENSG00000113319 O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2  / reaction / complex
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex / reaction
 ENSG00000277586 NEFL / P07196 / neurofilament light  / complex / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / complex / reaction
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / reaction
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction
 ENSG00000126458 RRAS / P10301 / RAS related  / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / complex / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction / complex
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000111537 IFNG / P01579 / interferon gamma  / reaction
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / complex / reaction
 ENSG00000127914 AKAP9 / Q99996 / A-kinase anchoring protein 9  / complex / reaction
 ENSG00000077522 ACTN2 / P35609 / actinin alpha 2  / complex / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / complex / reaction
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / reaction
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000058335 Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1  / complex / reaction
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction






 

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