ENSDARG00000100089


Danio rerio

Features
Gene ID: ENSDARG00000100089
  
Biological name :camk2b2
  
Synonyms : calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2 / camk2b2
  
Possible biological names infered from orthology : calcium/calmodulin dependent protein kinase II beta / Calcium/calmodulin-dependent protein kinase type II subunit beta / CAMK2B / P28652 / Q13554
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 45071603
Gene end: 45134581
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000139242
Ensembl peptide - ENSDARP00000139563
Ensembl peptide - ENSDARP00000143257
Ensembl peptide - ENSDARP00000151243
swissprot - A0A0R4IGE9
swissprot - A0A0R4IVW3
swissprot - A0A0R4IXC9
swissprot - A0A286Y8I7
ZFIN ID - ZDB-GENE-090312-34
Ensembl - ENSDARG00000100089
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000033061Gallus gallus
 CAMK2BENSG00000058404Homo sapiens
 Camk2bENSMUSG00000057897Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
camk2b1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 / CAMK2B* / P28652* / Q13554* / calcium/calmodulin dependent protein kinase II beta* / Calcium/calmodulin-depend...ENSDARG0000001106591
camk2g2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2 / CAMK2G* / Q13555* / Q923T9* / calcium/calmodulin dependent protein kinase II gamma* / Calcium/calmodulin-depe...ENSDARG0000005620684
camk2g1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 / CAMK2G* / Q13555* / Q923T9* / calcium/calmodulin dependent protein kinase II gamma* / Calcium/calmodulin-depe...ENSDARG0000007139582
camk2d2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2ENSDARG0000001427382
Q6DEH3 / camk2d1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / CAMK2D* / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus c...ENSDARG0000004301076
camk2a / calcium/calmodulin-dependent protein kinase II alpha / Q9UQM7*ENSDARG0000005361772
si:ch73-60h1.1ENSDARG0000007850424
camk1gb / calcium/calmodulin-dependent protein kinase IGb / Q96NX5* / CAMK1G* / Q91VB2* / calcium/calmodulin dependent protein kinase IG* / Calcium/calmodulin-dependent protein kinase type 1G *ENSDARG0000000878822
camk1b / calcium/calmodulin-dependent protein kinase Ib / CAMK1* / Q14012* / Q91YS8* / calcium/calmodulin dependent protein kinase I*ENSDARG0000002947422
camkvl / CaM kinase-like vesicle-associated, likeENSDARG0000005700022
camk4 / calcium/calmodulin-dependent protein kinase IV / Q16566*ENSDARG0000000537222
camk1db / calcium/calmodulin-dependent protein kinase 1Db / CAMK1D* / Q8BW96* / Q8IU85* / calcium/calmodulin dependent protein kinase ID*ENSDARG0000001744622
camk1ga / calcium/calmodulin-dependent protein kinase IGa / Q96NX5* / CAMK1G* / Q91VB2* / calcium/calmodulin dependent protein kinase IG* / Calcium/calmodulin-dependent protein kinase type 1G *ENSDARG0000004452622
camk1a / calcium/calmodulin-dependent protein kinase Ia / CAMK1* / Q14012* / Q91YS8* / calcium/calmodulin dependent protein kinase I*ENSDARG0000006011621
camkva / CaM kinase-like vesicle-associated a / CAMKV* / Q8NCB2* / Q3UHL1* / CaM kinase like vesicle associated* / CaM kinase-like vesicle-associated protein *ENSDARG0000002796321
camk1da / calcium/calmodulin-dependent protein kinase 1Da / CAMK1D* / Q8BW96* / Q8IU85* / calcium/calmodulin dependent protein kinase ID*ENSDARG0000007490521
Q7SY49 / camkvb / CaM kinase-like vesicle-associated b / CAMKV* / Q8NCB2* / Q3UHL1* / CaM kinase like vesicle associated* / CaM kinase-like vesicle-associated protein *ENSDARG0000000514120
pskh1 / Q501V0 / protein serine kinase H1 / P11801* / Q91YA2*ENSDARG0000005671318
pnck / pregnancy up-regulated nonubiquitous CaM kinase / Q6P2M8* / Q9QYK9* / pregnancy upregulated non-ubiquitously expressed CaM kinase*ENSDARG0000004364818
si:ch211-27e6.1 / PSKH2* / Q96QS6* / protein serine kinase H2*ENSDARG0000009989817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR020636  Calcium/calmodulin-dependent/calcium-dependent protein kinase
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0035118 embryonic pectoral fin morphogenesis IMP
 biological_processGO:0046777 protein autophosphorylation IMP
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IMP
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased size , abnormal
Kupffers vesicle cilium decreased length , abnormal
Kupffers vesicle cilium decreased amount , abnormal
Kupffers vesicle calcium- and calmodulin-dependent protein kinase complex mislocalised posteriorly , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000155 somite somite malformed , abnormal
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 ZFA:0000339 digestive system digestive system inverted , abnormal
digestive system centered , abnormal
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 ZFA:0000360 heart tube heart tube inverted , abnormal
heart tube centered , abnormal
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 ZFA:0000509 epithalamus epithalamus inverted , abnormal
epithalamus aplastic , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001161 pectoral fin pectoral fin decreased length , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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