ENSDARG00000005372


Danio rerio

Features
Gene ID: ENSDARG00000005372
  
Biological name :camk4
  
Synonyms : calcium/calmodulin-dependent protein kinase IV / camk4
  
Possible biological names infered from orthology : Q16566
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 55763276
Gene end: 55848511
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000108452
Ensembl peptide - ENSDARP00000146100
NCBI entrez gene - 550270     See in Manteia.
RefSeq - NM_001017607
RefSeq Peptide - NP_001017607
swissprot - Q568I9
ZFIN ID - ZDB-GENE-050417-76
Ensembl - ENSDARG00000005372
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAMK4ENSGALG00000000244Gallus gallus
 CAMK4ENSG00000152495Homo sapiens
 Camk4ENSMUSG00000038128Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch73-60h1.1ENSDARG0000007850473
camk1b / calcium/calmodulin-dependent protein kinase Ib / CAMK1* / Q14012* / Q91YS8* / calcium/calmodulin dependent protein kinase I*ENSDARG0000002947440
camk1a / calcium/calmodulin-dependent protein kinase Ia / CAMK1* / Q14012* / Q91YS8* / calcium/calmodulin dependent protein kinase I*ENSDARG0000006011640
camk1db / calcium/calmodulin-dependent protein kinase 1Db / CAMK1D* / Q8BW96* / Q8IU85* / calcium/calmodulin dependent protein kinase ID*ENSDARG0000001744638
camk1da / calcium/calmodulin-dependent protein kinase 1Da / CAMK1D* / Q8BW96* / Q8IU85* / calcium/calmodulin dependent protein kinase ID*ENSDARG0000007490538
camk1ga / calcium/calmodulin-dependent protein kinase IGa / Q96NX5* / CAMK1G* / Q91VB2* / calcium/calmodulin dependent protein kinase IG* / Calcium/calmodulin-dependent protein kinase type 1G *ENSDARG0000004452637
camk2d2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2ENSDARG0000001427337
camk1gb / calcium/calmodulin-dependent protein kinase IGb / Q96NX5* / CAMK1G* / Q91VB2* / calcium/calmodulin dependent protein kinase IG* / Calcium/calmodulin-dependent protein kinase type 1G *ENSDARG0000000878837
pnck / pregnancy up-regulated nonubiquitous CaM kinase / Q6P2M8* / Q9QYK9* / pregnancy upregulated non-ubiquitously expressed CaM kinase*ENSDARG0000004364837
Q6DEH3 / camk2d1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / CAMK2D* / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus c...ENSDARG0000004301036
camk2g1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 / CAMK2G* / Q13555* / Q923T9* / calcium/calmodulin dependent protein kinase II gamma* / Calcium/calmodulin-depe...ENSDARG0000007139536
camk2b1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 / CAMK2B* / P28652* / Q13554* / calcium/calmodulin dependent protein kinase II beta* / Calcium/calmodulin-depend...ENSDARG0000001106536
camkva / CaM kinase-like vesicle-associated a / CAMKV* / Q8NCB2* / Q3UHL1* / CaM kinase like vesicle associated* / CaM kinase-like vesicle-associated protein *ENSDARG0000002796335
camk2g2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2 / CAMK2G* / Q13555* / Q923T9* / calcium/calmodulin dependent protein kinase II gamma* / Calcium/calmodulin-depe...ENSDARG0000005620635
camk2a / calcium/calmodulin-dependent protein kinase II alpha / Q9UQM7*ENSDARG0000005361735
Q7SY49 / camkvb / CaM kinase-like vesicle-associated b / CAMKV* / Q8NCB2* / Q3UHL1* / CaM kinase like vesicle associated* / CaM kinase-like vesicle-associated protein *ENSDARG0000000514134
pskh1 / Q501V0 / protein serine kinase H1 / P11801* / Q91YA2*ENSDARG0000005671334
si:ch211-27e6.1 / PSKH2* / Q96QS6* / protein serine kinase H2*ENSDARG0000009989834
camkvl / CaM kinase-like vesicle-associated, likeENSDARG0000005700033
camk2b2 / calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2 / CAMK2B* / P28652* / Q13554* / calcium/calmodulin dependent protein kinase II beta* / Calcium/calmodulin-depend...ENSDARG0000010008923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IBA
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0060216 definitive hemopoiesis IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
CaMK IV-mediated phosphorylation of CREB
CREB phosphorylation through the activation of CaMKK
Activation of CaMK IV


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000094 blood island blood island cell proliferation disrupted , abnormal
blood island decreased size , abnormal
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 ZFA:0009250 lymphocyte lymphocyte decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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 ZFA:0009265 monocyte monocyte decreased amount , abnormal
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 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / complex






 

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