ENSMUSG00000038128


Mus musculus

Features
Gene ID: ENSMUSG00000038128
  
Biological name :Camk4
  
Synonyms : calcium/calmodulin-dependent protein kinase IV / Camk4
  
Possible biological names infered from orthology : Q16566
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B1
Gene start: 32939041
Gene end: 33195767
  
Corresponding Affymetrix probe sets: 10454632 (MoGene1.0st)   1421941_at (Mouse Genome 430 2.0 Array)   1426167_a_at (Mouse Genome 430 2.0 Array)   1439843_at (Mouse Genome 430 2.0 Array)   1441974_at (Mouse Genome 430 2.0 Array)   1452572_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046539
NCBI entrez gene - 12326     See in Manteia.
MGI - MGI:88258
RefSeq - XM_006525547
RefSeq - NM_009793
RefSeq - XM_006525544
RefSeq - XM_006525546
RefSeq - XM_006525543
RefSeq Peptide - NP_033923
swissprot - Q8BGR3
Ensembl - ENSMUSG00000038128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camk4ENSDARG00000005372Danio rerio
 CAMK4ENSGALG00000000244Gallus gallus
 CAMK4ENSG00000152495Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Camk1 / Q91YS8 / calcium/calmodulin-dependent protein kinase I / Q14012*ENSMUSG0000003027232
Pnck / Q9QYK9 / pregnancy upregulated non-ubiquitously expressed CaM kinase / Q6P2M8* / pregnancy up-regulated nonubiquitous CaM kinase*ENSMUSG0000000201232
Camk1g / Q91VB2 / Calcium/calmodulin-dependent protein kinase type 1G / Q96NX5* / calcium/calmodulin dependent protein kinase IG*ENSMUSG0000001617932
Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*ENSMUSG0000005381931
Camk1d / Q8BW96 / calcium/calmodulin-dependent protein kinase ID / Q8IU85*ENSMUSG0000003914531
Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*ENSMUSG0000002182030
Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*ENSMUSG0000005789730
Camkv / Q3UHL1 / CaM kinase-like vesicle-associated protein / Q8NCB2* / CaM kinase like vesicle associated*ENSMUSG0000003293630
Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*ENSMUSG0000002461729
Pskh1 / Q91YA2 / protein serine kinase H1 / P11801*ENSMUSG0000004831027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
CaMK IV-mediated phosphorylation of CREB
CREB phosphorylation through the activation of CaMKK
Activation of CaMK IV


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Hps5ru2-2Btlr/Hps5ru2-2Btlr
Genetic Background: C57BL/6J-Hps5ru2-2Btlr

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Camk4tm1Tsmi/Camk4tm1Tsmi
Genetic Background: B6N.129S-Camk4tm1Tsmi

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc
Genetic Background: involves: 129

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau
Genetic Background: B6.129P2-Nos2tm1Lau/J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hps5ru2-2Btlr/Hps5ru2-2Btlr
Genetic Background: C57BL/6J-Hps5ru2-2Btlr

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hps5ru2-2Btlr/Hps5ru2-2Btlr
Genetic Background: C57BL/6J-Hps5ru2-2Btlr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fertm1Pag/Fertm1Pag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Camk4tm1Tch/Camk4tm1Tch
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002915 abnormal synaptic depression "changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hps5ru2-2Btlr/Hps5ru2-2Btlr
Genetic Background: C57BL/6J-Hps5ru2-2Btlr

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hps5ru2-2Btlr/Hps5ru2-2Btlr
Genetic Background: C57BL/6J-Hps5ru2-2Btlr

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Camk4tm1Tch/Camk4tm1Tch
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk4tm1Tsmi/Camk4tm1Tsmi
Genetic Background: B6N.129S-Camk4tm1Tsmi

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hps5ru2-2Btlr/Hps5ru2-2Btlr
Genetic Background: C57BL/6J-Hps5ru2-2Btlr

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hps5ru2-2Btlr/Hps5ru2-2Btlr
Genetic Background: C57BL/6J-Hps5ru2-2Btlr

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk4tm1Tch/Camk4tm1Tch
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009433 polyovular ovarian follicle "an ovarian follicle containing more than one oocyte (ovum)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk4tm1Tsmi/Camk4tm1Tsmi
Genetic Background: B6N.129S-Camk4tm1Tsmi

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk4tm1Tsmi/Camk4tm1Tsmi
Genetic Background: B6N.129S-Camk4tm1Tsmi

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hps5ru2-2Btlr/Hps5ru2-2Btlr
Genetic Background: C57BL/6J-Hps5ru2-2Btlr

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hps5ru2-2Btlr/Hps5ru2-2Btlr
Genetic Background: C57BL/6J-Hps5ru2-2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction






 

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