ENSMUSG00000053819


Mus musculus

Features
Gene ID: ENSMUSG00000053819
  
Biological name :Camk2d
  
Synonyms : Camk2d / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q6PHZ2
  
Possible biological names infered from orthology : calcium/calmodulin dependent protein kinase II delta / Q13557
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 126596302
Gene end: 126846326
  
Corresponding Affymetrix probe sets: 10495896 (MoGene1.0st)   1422659_at (Mouse Genome 430 2.0 Array)   1427763_a_at (Mouse Genome 430 2.0 Array)   1439168_at (Mouse Genome 430 2.0 Array)   1444031_at (Mouse Genome 430 2.0 Array)   1456844_at (Mouse Genome 430 2.0 Array)   1459457_at (Mouse Genome 430 2.0 Array)   1460630_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114801
Ensembl peptide - ENSMUSP00000102010
Ensembl peptide - ENSMUSP00000129999
Ensembl peptide - ENSMUSP00000143677
Ensembl peptide - ENSMUSP00000143504
Ensembl peptide - ENSMUSP00000133019
Ensembl peptide - ENSMUSP00000130769
Ensembl peptide - ENSMUSP00000130305
Ensembl peptide - ENSMUSP00000063359
Ensembl peptide - ENSMUSP00000066996
Ensembl peptide - ENSMUSP00000102007
Ensembl peptide - ENSMUSP00000102008
Ensembl peptide - ENSMUSP00000102009
NCBI entrez gene - 108058     See in Manteia.
MGI - MGI:1341265
RefSeq - XM_017319422
RefSeq - XM_006500823
RefSeq - XM_006500824
RefSeq - XM_006500825
RefSeq - XM_006500826
RefSeq - XM_006500829
RefSeq - XM_006500831
RefSeq - XM_006500832
RefSeq - XM_006500833
RefSeq - XM_006500834
RefSeq - XM_006500835
RefSeq - XM_006500836
RefSeq - XM_006500839
RefSeq - XM_017319415
RefSeq - XM_017319416
RefSeq - XM_017319417
RefSeq - XM_017319418
RefSeq - XM_017319419
RefSeq - XM_017319420
RefSeq - XM_017319421
RefSeq - NM_001025438
RefSeq - NM_001025439
RefSeq - NM_001293663
RefSeq - NM_001293664
RefSeq - NM_001293665
RefSeq - NM_001293666
RefSeq - NM_001346635
RefSeq - NM_001346636
RefSeq - NM_023813
RefSeq - XM_006500816
RefSeq - XM_006500817
RefSeq - XM_006500818
RefSeq - XM_006500819
RefSeq - XM_006500820
RefSeq - XM_006500822
RefSeq Peptide - NP_001280592
RefSeq Peptide - NP_001280593
RefSeq Peptide - NP_001280594
RefSeq Peptide - NP_001280595
RefSeq Peptide - NP_001333564
RefSeq Peptide - NP_001333565
RefSeq Peptide - NP_076302
RefSeq Peptide - NP_001020609
RefSeq Peptide - NP_001020610
swissprot - Q6PHZ2
swissprot - Q8CCM0
swissprot - E9Q1W0
swissprot - E9Q1V9
swissprot - E9Q1T1
swissprot - E9PXV3
swissprot - F6RWZ9
swissprot - D6RDQ8
swissprot - A0A0G2JGS4
swissprot - E9QAJ4
Ensembl - ENSMUSG00000053819
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6DEH3ENSDARG00000043010Danio rerio
 CAMK2DENSGALG00000041635Gallus gallus
 CAMK2DENSG00000145349Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*ENSMUSG0000002182083
Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*ENSMUSG0000005789781
Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*ENSMUSG0000002461778
Camk1g / Q91VB2 / Calcium/calmodulin-dependent protein kinase type 1G / Q96NX5* / calcium/calmodulin dependent protein kinase IG*ENSMUSG0000001617928
Camk4 / calcium/calmodulin-dependent protein kinase IV / Q16566*ENSMUSG0000003812827
Camk1 / Q91YS8 / calcium/calmodulin-dependent protein kinase I / Q14012*ENSMUSG0000003027225
Camk1d / Q8BW96 / calcium/calmodulin-dependent protein kinase ID / Q8IU85*ENSMUSG0000003914525
Pnck / Q9QYK9 / pregnancy upregulated non-ubiquitously expressed CaM kinase / Q6P2M8* / pregnancy up-regulated nonubiquitous CaM kinase*ENSMUSG0000000201225
Pskh1 / Q91YA2 / protein serine kinase H1 / P11801*ENSMUSG0000004831022
Camkv / Q3UHL1 / CaM kinase-like vesicle-associated protein / Q8NCB2* / CaM kinase like vesicle associated*ENSMUSG0000003293622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002028 regulation of sodium ion transport IDA
 biological_processGO:0003254 regulation of membrane depolarization ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy ISO
 biological_processGO:0010649 regulation of cell communication by electrical coupling IEA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0030007 cellular potassium ion homeostasis IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0035022 positive regulation of Rac protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051259 protein complex oligomerization ISO
 biological_processGO:0055119 relaxation of cardiac muscle IEA
 biological_processGO:0060048 cardiac muscle contraction IDA
 biological_processGO:0060341 regulation of cellular localization ISO
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0086003 cardiac muscle cell contraction IEA
 biological_processGO:0098901 regulation of cardiac muscle cell action potential IEA
 biological_processGO:1901897 regulation of relaxation of cardiac muscle IEA
 biological_processGO:1902306 negative regulation of sodium ion transmembrane transport ISO
 biological_processGO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 cellular_componentGO:0030315 T-tubule IDA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0034704 calcium channel complex IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043194 axon initial segment IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019871 sodium channel inhibitor activity ISO
 molecular_functionGO:0031432 titin binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Interferon gamma signaling
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004088 abnormal sarcoplasmic reticulum morphology "any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Rapgef3tm1.2Chen/Rapgef3tm1.2Chen,Rapgef4tm1.2Chen/Rapgef4tm1.2Chen
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Camk2dtm1.1Jhb/Camk2dtm1.1Jhb
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / complex / reaction
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction / complex
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / complex / reaction
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / reaction / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / reaction / complex
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction / complex
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / reaction / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / reaction
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / reaction
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex / reaction
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / complex / reaction
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction






 

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