ENSMUSG00000022556


Mus musculus

Features
Gene ID: ENSMUSG00000022556
  
Biological name :Hsf1
  
Synonyms : heat shock factor 1 / Hsf1 / P38532
  
Possible biological names infered from orthology : heat shock transcription factor 1 / Q00613
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D3
Gene start: 76477422
Gene end: 76501913
  
Corresponding Affymetrix probe sets: 10424909 (MoGene1.0st)   1424622_at (Mouse Genome 430 2.0 Array)   1443293_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154602
Ensembl peptide - ENSMUSP00000155104
Ensembl peptide - ENSMUSP00000154799
Ensembl peptide - ENSMUSP00000154638
Ensembl peptide - ENSMUSP00000072617
Ensembl peptide - ENSMUSP00000154328
Ensembl peptide - ENSMUSP00000154346
Ensembl peptide - ENSMUSP00000154356
Ensembl peptide - ENSMUSP00000154386
Ensembl peptide - ENSMUSP00000154526
NCBI entrez gene - 15499     See in Manteia.
MGI - MGI:96238
RefSeq - XM_006520473
RefSeq - XM_006520474
RefSeq - XM_006520475
RefSeq - XM_006520476
RefSeq - XM_006520472
RefSeq - NM_008296
RefSeq - XM_006520471
RefSeq Peptide - NP_001318082
RefSeq Peptide - NP_001318083
RefSeq Peptide - NP_032322
swissprot - P38532
swissprot - A0A075F882
swissprot - A0A075F5C6
swissprot - A0A075F891
swissprot - Q52L52
Ensembl - ENSMUSG00000022556
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsf1ENSDARG00000008818Danio rerio
 HSF1ENSG00000185122Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hsf2 / P38533 / Heat shock factor protein 2 / Q03933* / heat shock transcription factor 2*ENSMUSG0000001987834
Hsf4 / Q9R0L1 / Heat shock factor protein 4 / Q9ULV5* / heat shock transcription factor 4*ENSMUSG0000003324933
Hsf3ENSMUSG0000004580224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000232  Heat shock factor (HSF)-type, DNA-binding
 IPR010542  Vertebrate heat shock transcription factor, C-terminal domain
 IPR027725  Heat shock transcription factor family
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0000165 MAPK cascade ISS
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007143 female meiotic nuclear division IMP
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0009299 mRNA transcription ISO
 biological_processGO:0009408 response to heat IMP
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0034605 cellular response to heat ISS
 biological_processGO:0034620 cellular response to unfolded protein ISO
 biological_processGO:0034622 cellular protein-containing complex assembly ISS
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035865 cellular response to potassium ion IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity ISS
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0060136 embryonic process involved in female pregnancy IMP
 biological_processGO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress ISO
 biological_processGO:0070207 protein homotrimerization ISO
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071276 cellular response to cadmium ion ISS
 biological_processGO:0071280 cellular response to copper ion ISS
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071478 cellular response to radiation IEA
 biological_processGO:0071480 cellular response to gamma radiation ISO
 biological_processGO:0072738 cellular response to diamide ISO
 biological_processGO:0090084 negative regulation of inclusion body assembly IEA
 biological_processGO:0090261 positive regulation of inclusion body assembly IEA
 biological_processGO:1900034 regulation of cellular response to heat ISS
 biological_processGO:1900365 positive regulation of mRNA polyadenylation ISO
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901652 response to peptide IEA
 biological_processGO:1902512 positive regulation of apoptotic DNA fragmentation IEA
 biological_processGO:1903936 cellular response to sodium arsenite ISO
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:1904528 positive regulation of microtubule binding IEA
 biological_processGO:1904843 cellular response to nitroglycerin IEA
 biological_processGO:1904845 cellular response to L-glutamine IEA
 biological_processGO:1990910 response to hypobaric hypoxia IEA
 biological_processGO:1990911 response to psychosocial stress IEA
 biological_processGO:2001033 negative regulation of double-strand break repair via nonhomologous end joining ISO
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000791 euchromatin IEA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016605 PML body ISS
 cellular_componentGO:0045120 pronucleus IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0097165 nuclear stress granule ISO
 cellular_componentGO:0097431 mitotic spindle pole ISS
 cellular_componentGO:1990904 ribonucleoprotein complex ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0031072 heat shock protein binding ISS
 molecular_functionGO:0031490 chromatin DNA binding ISS
 molecular_functionGO:0042802 identical protein binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0043621 protein self-association ISS
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0051879 Hsp90 protein binding ISS
 molecular_functionGO:0061770 translation elongation factor binding ISO
 molecular_functionGO:0097677 STAT family protein binding IEA
 molecular_functionGO:0098847 sequence-specific single stranded DNA binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSF1 activation
Attenuation phase
HSF1-dependent transactivation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vsx1tm2Mci/Vsx1tm2Mci
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vsx1tm2Mci/Vsx1tm2Mci
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Hsf1tm1Miv/Hsf1tm1Miv,Hsf2tm1Miv/Hsf2tm1Miv
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Tnfsf4Ath1-BALB/cJ/?
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Vsx1tm2Mci/Vsx1tm2Mci
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)

Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Vsx1tm2Mci/Vsx1tm2Mci
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hsf1tm1Miv/Hsf1tm1Miv,Hsf2tm1Miv/Hsf2tm1Miv
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Vsx1tm2Mci/Vsx1tm2Mci
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)

Allelic Composition: Hsf1tm1Miv/Hsf1tm1Miv,Hsf2tm1Miv/Hsf2tm1Miv
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Vsx1tm2Mci/Vsx1tm2Mci
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grid2ho-17J/Grid2ho-17J
Genetic Background: C57BL/6J-Grid2ho-17J/J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vsx1tm2Mci/Vsx1tm2Mci
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsf1tm1Miv/Hsf1tm1Miv,Hsf2tm1Miv/Hsf2tm1Miv
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Tg(ACTB-HSF1)1Anak/?
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0004079 abnormal putamen morphology "malformation of the lens-shaped basal ganglion involved with control of voluntary movement in the brain" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Tg(ACTB-HSF1)1Anak/?
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hsf1tm1Miv/Hsf1tm1Miv,Hsf2tm1Miv/Hsf2tm1Miv
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsf1tm1.1Echr/Hsf1tm1.1Echr,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hsf1tm1Miv/Hsf1tm1Miv,Hsf2tm1Miv/Hsf2tm1Miv
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb,Tg(TTR-V30M)15Imeg/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb,Tg(TTR-V30M)15Imeg/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

 MP:0008841 ruptured lens capsule "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vsx1tm2Mci/Vsx1tm2Mci
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0009769 abnormal meiotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosomes by inhibiting cell-cycle progression in response to a signal generated by meiotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:18596218]
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsf1tm1.1Echr/Hsf1tm1.1Echr,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hsf1tm1Miv/Hsf1tm1Miv,Hsf2tm1Miv/Hsf2tm1Miv
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
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Allelic Composition: Hsf1tm1Miv/Hsf1tm1Miv,Hsf2tm1Miv/Hsf2tm1Miv
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000016528 P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*  / reaction
 ENSMUSG00000020063 Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / reaction / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction / complex
 ENSMUSG00000030357 Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*  / complex / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / reaction / complex
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000091971 Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / complex / reaction
 ENSMUSG00000015656 Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*  / complex / reaction
 ENSMUSG00000031839 Hsbp1 / Q9CQZ1 / Heat shock factor-binding protein 1 / O75506*  / complex / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / complex / reaction
 ENSMUSG00000005483 Dnajb1 / Q9QYJ3 / DnaJ homolog subfamily B member 1 / P25685* / DnaJ heat shock protein family (Hsp40) member B1*  / reaction / complex
 ENSMUSG00000090877 P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction / complex






 

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