Manteia

ENSMUSG00000005483

Mus musculus

Features

Gene ID:	ENSMUSG00000005483

Biological name :	Dnajb1

Synonyms :	Dnajb1 / DnaJ homolog subfamily B member 1 / Q9QYJ3

Possible biological names infered from orthology :	DnaJ heat shock protein family (Hsp40) member B1 / P25685

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	C2
Gene start:	83608193
Gene end:	83612653

Corresponding Affymetrix probe sets:	10573198 (MoGene1.0st) 1416755_at (Mouse Genome 430 2.0 Array) 1416756_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000005620 Ensembl peptide - ENSMUSP00000148685 NCBI entrez gene - 81489 See in Manteia. MGI - MGI:1931874 RefSeq - NM_018808 RefSeq - NM_001308227 RefSeq Peptide - NP_001295156 RefSeq Peptide - NP_061278 swissprot - Q3TU79 swissprot - Q3TYL7 swissprot - Q9QYJ3 Ensembl - ENSMUSG00000005483

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Dnajb5 / O89114 / Mus musculus DnaJ heat shock protein family (Hsp40) member B5 (Dnajb5), transcript variant 3, mRNA. / O75953* / DnaJ heat shock protein family (Hsp40) member B5*	ENSMUSG00000036052	64
Dnajb4 / Q9D832 / DnaJ homolog subfamily B member 4 / Q9UDY4* / DnaJ heat shock protein family (Hsp40) member B4*	ENSMUSG00000028035	64
Q80Y75 / Dnajb13 / DnaJ homolog subfamily B member 13 / P59910* / DnaJ heat shock protein family (Hsp40) member B13*	ENSMUSG00000030708	46
Dnajb6 / O54946 / DnaJ homolog subfamily B member 6	ENSMUSG00000029131	26
Dnajb3	ENSMUSG00000081984	23
Dnajb2 / Q9QYI5 / DnaJ homolog subfamily B member 2 / P25686* / DnaJ heat shock protein family (Hsp40) member B2*	ENSMUSG00000026203	22
Dnajb7 / Q9QYI8 / DnaJ homolog subfamily B member 7 / Q7Z6W7* / DnaJ heat shock protein family (Hsp40) member B7*	ENSMUSG00000047108	21
Dnajb8 / Q9QYI7 / DnaJ homolog subfamily B member 8 / Q8NHS0* / DnaJ heat shock protein family (Hsp40) member B8*	ENSMUSG00000048206	21
Dnajb9 / Q9QYI6 / DnaJ homolog subfamily B member 9 / Q9UBS3* / DnaJ heat shock protein family (Hsp40) member B9*	ENSMUSG00000014905	18
4930503B20Rik / RIKEN cDNA 4930503B20 gene	ENSMUSG00000090202	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR001623	DnaJ domain
IPR002939	Chaperone DnaJ, C-terminal
IPR008971	HSP40/DnaJ peptide-binding
IPR018253	DnaJ domain, conserved site
IPR036869	Chaperone J-domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006457	protein folding	IEA
biological_process	GO:0032781	positive regulation of ATPase activity	IEA
biological_process	GO:0051085	chaperone cofactor-dependent protein refolding	IEA
biological_process	GO:0090084	negative regulation of inclusion body assembly	IEA
biological_process	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0001671	ATPase activator activity	IEA
molecular_function	GO:0030544	Hsp70 protein binding	IEA
molecular_function	GO:0045296	cadherin binding	IEA
molecular_function	GO:0051082	unfolded protein binding	IEA
molecular_function	GO:0051087	chaperone binding	IEA
molecular_function	GO:0051117	ATPase binding	IEA

Pathways (from Reactome)

Pathway description

Regulation of HSF1-mediated heat shock response

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Eloa^tm1Aso/Eloa^tm1Aso,Trp53^tm1Sia/Trp53^tm1Sia Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000005483	Dnajb1 / Q9QYJ3 / DnaJ homolog subfamily B member 1 / P25685* / DnaJ heat shock protein family (Hsp40) member B1*	/ complex
ENSMUSG00000062797	Q9DD02 / Hikeshi / Protein Hikeshi / Q53FT3* / Hikeshi, heat shock protein nuclear import factor*	/ reaction
ENSMUSG00000091971	Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*	/ reaction / complex
ENSMUSG00000015656	Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*	/ complex
ENSMUSG00000090877	P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*	/ complex / reaction
ENSMUSG00000029454	O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*	/ complex / reaction
ENSMUSG00000020063	Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*	/ reaction / complex
ENSMUSG00000055024	Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*	/ reaction
ENSMUSG00000022556	Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*	/ complex / reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr