ENSMUSG00000055024


Mus musculus

Features
Gene ID: ENSMUSG00000055024
  
Biological name :Ep300
  
Synonyms : B2RWS6 / Ep300 / Histone acetyltransferase p300
  
Possible biological names infered from orthology : E1A binding protein p300 / Q09472
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 81585351
Gene end: 81652077
  
Corresponding Affymetrix probe sets: 10425527 (MoGene1.0st)   1434765_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066789
Ensembl peptide - ENSMUSP00000146251
Ensembl peptide - ENSMUSP00000145639
Ensembl peptide - ENSMUSP00000139889
NCBI entrez gene - 328572     See in Manteia.
MGI - MGI:1276116
RefSeq - XM_006521091
RefSeq - NM_177821
RefSeq - XM_006521089
RefSeq - XM_006521090
RefSeq Peptide - NP_808489
swissprot - B2RWS6
swissprot - A0A0U1RNN6
swissprot - A0A087WPR8
swissprot - A0A0U1RQ52
Ensembl - ENSMUSG00000055024
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ep300aENSDARG00000100666Danio rerio
 ep300bENSDARG00000061108Danio rerio
 EP300ENSGALG00000011992Gallus gallus
 EP300ENSG00000100393Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crebbp / CREB binding protein / Q92793*ENSMUSG0000002252161
Brd4 / Q9ESU6 / Bromodomain-containing protein 4 / O60885* / bromodomain containing 4*ENSMUSG0000002400211
Baz2a / bromodomain adjacent to zinc finger domain 2A / Q9UIF9*ENSMUSG000000400548
Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*ENSMUSG000000243358
Baz2b / bromodomain adjacent to zinc finger domain, 2B / Q9UIF8*ENSMUSG000000269878
Brd3 / Q8K2F0 / Bromodomain-containing protein 3 / Q15059* / bromodomain containing 3*ENSMUSG000000269187
Brdt / Q91Y44 / Bromodomain testis-specific protein / Q58F21* / bromodomain testis associated*ENSMUSG000000292797
Baz1a / O88379 / Bromodomain adjacent to zinc finger domain protein 1A / Q9NRL2* / bromodomain adjacent to zinc finger domain 1A*ENSMUSG000000350216
Baz1b / Q9Z277 / Tyrosine-protein kinase BAZ1B / Q9UIG0* / bromodomain adjacent to zinc finger domain 1B*ENSMUSG000000027484


Protein motifs (from Interpro)
Interpro ID Name
 IPR000197  Zinc finger, TAZ-type
 IPR000433  Zinc finger, ZZ-type
 IPR001487  Bromodomain
 IPR003101  Coactivator CBP, KIX domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010303  CREB-binding protein/p300, atypical RING domain
 IPR013178  Histone acetyltransferase Rtt109/CBP
 IPR014744  Nuclear receptor coactivator, CREB-bp-like, interlocking
 IPR018359  Bromodomain, conserved site
 IPR031162  CBP/p300-type histone acetyltransferase domain
 IPR035898  TAZ domain superfamily
 IPR036427  Bromodomain-like superfamily
 IPR036529  Coactivator CBP, KIX domain superfamily
 IPR037073  Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006473 protein acetylation IDA
 biological_processGO:0006475 internal protein amino acid acetylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010742 macrophage derived foam cell differentiation IEA
 biological_processGO:0016573 histone acetylation IDA
 biological_processGO:0018076 N-terminal peptidyl-lysine acetylation ISS
 biological_processGO:0018393 internal peptidyl-lysine acetylation IEA
 biological_processGO:0018394 peptidyl-lysine acetylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030220 platelet formation IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0032460 negative regulation of protein oligomerization IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0043923 positive regulation by host of viral transcription IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0043969 histone H2B acetylation IEA
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045815 positive regulation of gene expression, epigenetic IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051216 cartilage development NAS
 biological_processGO:0060765 regulation of androgen receptor signaling pathway IEA
 biological_processGO:0061921 peptidyl-lysine propionylation IEA
 biological_processGO:0090043 regulation of tubulin deacetylation IEA
 biological_processGO:0140066 peptidyl-lysine crotonylation IEA
 biological_processGO:0140067 peptidyl-lysine butyrylation IDA
 cellular_componentGO:0000123 histone acetyltransferase complex IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0004402 histone acetyltransferase activity ISO
 molecular_functionGO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016407 acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups ISO
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding IEA
 molecular_functionGO:0061920 protein propionyltransferase activity IEA
 molecular_functionGO:0097157 pre-mRNA intronic binding IDA
 molecular_functionGO:0097677 STAT family protein binding IEA
 molecular_functionGO:0140065 peptide butyryltransferase activity IEA
 molecular_functionGO:0140068 histone crotonyltransferase activity IEA
 molecular_functionGO:0140069 histone butyryltransferase activity IDA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
HATs acetylate histones
Attenuation phase
SUMOylation of transcription cofactors
B-WICH complex positively regulates rRNA expression
CD209 (DC-SIGN) signaling
Metalloprotease DUBs
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Methylation
PI5P Regulates TP53 Acetylation
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ep300tm1Dli/Ep300+
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129-Crebbptm2Pkb x 129-Crebbptm2Pkb)F1

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ep300tm1Pkb/Ep300tm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ep300tm1Pkb/Ep300+,Mybtm1Ssp/Myb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ep300tm2Pkb/Ep300tm2Pkb,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: CD-1 * JF1

Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: CD-1 * JF1

Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

Allelic Composition: Ep300tm1Pkb/Ep300tm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ep300tm1Pkb/Ep300tm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Ep300tm1Dli/Ep300+
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: CD-1 * JF1

Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Ep300tm1Dli/Ep300+
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300tm3Pkb
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr9M5Btlr/?
Genetic Background: C57BL/6J-Tlr9M5Btlr

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * FVB/N

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300tm3Pkb
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1.1Wtp/Srftm1.1Wtp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ep300tm1Pkb/Ep300+,Mybtm1Ssp/Myb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tlr9M5Btlr/?
Genetic Background: C57BL/6J-Tlr9M5Btlr

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ep300tm1Pkb/Ep300tm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ep300tm1Pkb/Ep300tm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * FVB/N

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat3tm2Aki/Stat3tm2Aki
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ep300tm2Pkb/Ep300tm2Pkb,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ep300tm2Pkb/Ep300tm2Pkb,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ep300tm2Pkb/Ep300tm2Pkb,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ep300tm1Pkb/Ep300tm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ep300tm1Pkb/Ep300+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ep300tm1Pkb/Ep300+,Mybtm1Ssp/Myb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ep300Plt6/Ep300Plt6
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ep300tm2Pkb/Ep300tm2Pkb,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ep300tm2Pkb/Ep300tm2Pkb,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008188 abnormal transitional stage B cell morphology "any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008240 abnormal spleen marginal zone macrophage morphology "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Ep300tm1Pkb/Ep300tm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ep300Plt6/Ep300Plt6,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ep300Plt6/Ep300+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0010138 arteritis "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0010500 myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0010592 abnormal atrioventricular septum morphology "any structural anomaly of the wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ep300tm1Pkb/Ep300tm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ep300tm3Pkb/Ep300tm3Pkb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

Allelic Composition: Ep300tm1Dli/Ep300+
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300tm3Pkb
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Ep300tm1Dli/Ep300tm1Dli
Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006288 Ttc5 / Q99LG4 / tetratricopeptide repeat domain 5 / Q8N0Z6*  / complex / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex / reaction
 ENSMUSG00000020918 Kat2a / Q9JHD2 / K(lysine) acetyltransferase 2A / Q92830* / lysine acetyltransferase 2A*  / complex / reaction
 ENSMUSG00000015522 Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*  / complex
 ENSMUSG00000024140 Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*  / complex
 ENSMUSG00000022346 Myc / P01108 / myelocytomatosis oncogene / P01106* / MYC proto-oncogene, bHLH transcription factor*  / complex / reaction
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / complex / reaction
 ENSMUSG00000025927 Q61313 / Tfap2b / transcription factor AP-2 beta / Q92481*  / reaction / complex
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / complex / reaction
 ENSMUSG00000032238 Rora / P51448 / RAR-related orphan receptor alpha / P35398* / RAR related orphan receptor A*  / complex / reaction
 ENSMUSG00000028640 Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*  / complex / reaction
 ENSMUSG00000004328 Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*  / complex
 ENSMUSG00000029167 O70343 / Ppargc1a / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Q9UBK2* / PPARG coactivator 1 alpha*  / reaction / complex
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / complex / reaction
 ENSMUSG00000031660 Brd7 / O88665 / Bromodomain-containing protein 7 / Q9NPI1* / bromodomain containing 7*  / complex / reaction
 ENSMUSG00000039910 Cited2 / O35740 / Cbp/p300-interacting transactivator 2 / Q99967* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2*  / reaction / complex
 ENSMUSG00000021690 Jmy / junction mediating and regulatory protein, p53 cofactor / Q8N9B5*  / complex / reaction
 ENSMUSG00000070691 Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*  / reaction / complex
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction / complex
 ENSMUSG00000036523 Greb1 / Q3UHK3 / Protein GREB1 / Q4ZG55* / growth regulation by estrogen in breast cancer 1*  / reaction / complex
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction / complex
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / complex / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000051159 Cited1 / P97769 / Cbp/p300-interacting transactivator 1 / Q99966* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1*  / reaction / complex
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / reaction / complex
 ENSMUSG00000023110 Prmt5 / protein arginine N-methyltransferase 5 / O14744* / protein arginine methyltransferase 5*  / reaction / complex
 ENSMUSG00000024335 Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*  / reaction / complex
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000039191 Rbpj / P31266 / Recombining binding protein suppressor of hairless / Q06330* / recombination signal binding protein for immunoglobulin kappa J region*  / complex / reaction
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / reaction / complex
 ENSMUSG00000091971 Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000005483 Dnajb1 / Q9QYJ3 / DnaJ homolog subfamily B member 1 / P25685* / DnaJ heat shock protein family (Hsp40) member B1*  / reaction
 ENSMUSG00000090877 P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction
 ENSMUSG00000015656 Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*  / reaction
 ENSMUSG00000000708 Kat2b / Q9JHD1 / Histone acetyltransferase KAT2B / Q92831* / lysine acetyltransferase 2B*  / reaction / complex
 ENSMUSG00000027678 Ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000020647 Ncoa1 / P70365 / Nuclear receptor coactivator 1 / Q15788*  / reaction / complex
 ENSMUSG00000062627 Mysm1 / Q69Z66 / Histone H2A deubiquitinase MYSM1 / Q5VVJ2* / Myb like, SWIRM and MPN domains 1*  / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000070803 Cited4 / Q9WUL8 / Cbp/p300-interacting transactivator 4 / Q96RK1* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4*  / reaction / complex
 ENSMUSG00000063049 Ing2 / Q9ESK4 / Inhibitor of growth protein 2 / Q9H160* / inhibitor of growth family member 2*  / complex / reaction
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000061436 Hipk2 / Q9QZR5 / homeodomain interacting protein kinase 2 / Q9H2X6*  / reaction






 

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