ENSMUSG00000025958


Mus musculus

Features
Gene ID: ENSMUSG00000025958
  
Biological name :Creb1
  
Synonyms : Creb1 / Cyclic AMP-responsive element-binding protein 1 / Q01147
  
Possible biological names infered from orthology : cAMP responsive element binding protein 1 / P16220
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C2
Gene start: 64532645
Gene end: 64604548
  
Corresponding Affymetrix probe sets: 10346943 (MoGene1.0st)   1421582_a_at (Mouse Genome 430 2.0 Array)   1421583_at (Mouse Genome 430 2.0 Array)   1423402_at (Mouse Genome 430 2.0 Array)   1428755_at (Mouse Genome 430 2.0 Array)   1452529_a_at (Mouse Genome 430 2.0 Array)   1452901_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140649
Ensembl peptide - ENSMUSP00000140112
Ensembl peptide - ENSMUSP00000140189
Ensembl peptide - ENSMUSP00000059973
Ensembl peptide - ENSMUSP00000084624
Ensembl peptide - ENSMUSP00000132860
Ensembl peptide - ENSMUSP00000139995
NCBI entrez gene - 12912     See in Manteia.
MGI - MGI:88494
RefSeq - XM_017314099
RefSeq - NM_001037726
RefSeq - NM_009952
RefSeq - NM_133828
RefSeq - XM_006495650
RefSeq - XM_006495651
RefSeq - XM_006495652
RefSeq - XM_006495653
RefSeq - XM_006495654
RefSeq - XM_011238424
RefSeq - XM_017314080
RefSeq Peptide - NP_034082
RefSeq Peptide - NP_598589
RefSeq Peptide - NP_001032815
swissprot - Q543W0
swissprot - Q547S9
swissprot - Q62347
swissprot - Q61441
swissprot - A0A087WRI6
swissprot - Q01147
Ensembl - ENSMUSG00000025958
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 creb1aENSDARG00000053586Danio rerio
 creb1bENSDARG00000093420Danio rerio
 CREB1ENSGALG00000008494Gallus gallus
 CREB1ENSG00000118260Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crem / P27699 / cAMP-responsive element modulator / Q03060*ENSMUSG0000006388959
Atf1 / P81269 / Cyclic AMP-dependent transcription factor ATF-1 / P18846* / activating transcription factor 1*ENSMUSG0000002302749


Protein motifs (from Interpro)
Interpro ID Name
 IPR001630  cAMP response element binding (CREB) protein
 IPR003102  Coactivator CBP, pKID
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029802  cAMP-responsive element-binding protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0007595 lactation IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0007623 circadian rhythm IDA
 biological_processGO:0008361 regulation of cell size IGI
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010033 response to organic substance ISO
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding ISO
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0032916 positive regulation of transforming growth factor beta3 production IEA
 biological_processGO:0033363 secretory granule organization IMP
 biological_processGO:0033762 response to glucagon IMP
 biological_processGO:0034670 chemotaxis to arachidonic acid IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IGI
 biological_processGO:0045672 positive regulation of osteoclast differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046887 positive regulation of hormone secretion IMP
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IGI
 biological_processGO:0048145 regulation of fibroblast proliferation IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0055025 positive regulation of cardiac muscle tissue development IMP
 biological_processGO:0060251 regulation of glial cell proliferation IEA
 biological_processGO:0060428 lung epithelium development IMP
 biological_processGO:0060430 lung saccule development IMP
 biological_processGO:0060509 type I pneumocyte differentiation IMP
 biological_processGO:0071294 cellular response to zinc ion IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1902065 response to L-glutamate IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005719 nuclear euchromatin ISO
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:1990589 ATF4-CREB1 transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding ISO
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding ISO
 molecular_functionGO:0001225 RNA polymerase II transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0035497 cAMP response element binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:1990763 arrestin family protein binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus
CREB phosphorylation
NCAM signaling for neurite out-growth
CREB phosphorylation through the activation of CaMKK
CREB phosphorylation through the activation of Adenylate Cyclase
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001017 abnormal stellate ganglion morphology "malformation or absence of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Creb1tm3.1Gsc/Creb1tm3.1Gsc,Cremtm1Gsc/Cremtm1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001468 abnormal temporal memory "anomaly in the ability to recall temporal events and stimuli" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001694 failure to form egg cylinders "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm3Gsc/Creb1tm3Gsc,Tg(Dbh-icre)1Gsc/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnfrsf1atm1Blt/Tnfrsf1atm1Blt,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0003695 delayed hatching from the zona pellucida "the embryo takes longer than normal to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Htr1btm1Rhn/Htr1b+
Genetic Background: involves: 129S2/SvPas

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap2+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0009415 skeletal muscle degeneration "pathological deterioration of skeletal muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Creb1tm1.1Berd/Creb1tm1.1Berd,Dmdmdx/Y
Genetic Background: B.Cg-Creb1tm1.1Berd Dmdmdx

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0009776 decreased behavioral withdrawal response "decrease in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aw-47J/Aw-47J
Genetic Background: C57BL/6J-Aw-47J

 MP:0010887 pale lung "lung lacking normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ptpn6m2Btlr/Ptpn6m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0013237 abnormal skeletal muscle regeneration "anomaly in the ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Creb1tm1.1Berd/Creb1tm1.1Berd,Dmdmdx/Y
Genetic Background: B.Cg-Creb1tm1.1Berd Dmdmdx

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Creb1tm3Gsc/Creb1+,Lrp5tm1Kry/Lrp5+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Tyrp1b/Tyrp1b-1MLP5
Genetic Background: involves: 101/Rl * C3H/Rl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction
 ENSMUSG00000003644 P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*  / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / reaction
 ENSMUSG00000016528 P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000023809 Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*  / reaction
 ENSMUSG00000038128 Camk4 / calcium/calmodulin-dependent protein kinase IV / Q16566*  / reaction
 ENSMUSG00000021180 Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*  / reaction
 ENSMUSG00000031309 P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*  / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000039191 Rbpj / P31266 / Recombining binding protein suppressor of hairless / Q06330* / recombination signal binding protein for immunoglobulin kappa J region*  / reaction / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction






 

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