ENSMUSG00000031309


Mus musculus

Features
Gene ID: ENSMUSG00000031309
  
Biological name :Rps6ka3
  
Synonyms : P18654 / ribosomal protein S6 kinase polypeptide 3 / Rps6ka3
  
Possible biological names infered from orthology : P51812 / ribosomal protein S6 kinase A3
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F4
Gene start: 159210307
Gene end: 159368244
  
Corresponding Affymetrix probe sets: 10602772 (MoGene1.0st)   1427299_at (Mouse Genome 430 2.0 Array)   1452383_at (Mouse Genome 430 2.0 Array)   1455206_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108111
Ensembl peptide - ENSMUSP00000108110
Ensembl peptide - ENSMUSP00000108112
Ensembl peptide - ENSMUSP00000123059
Ensembl peptide - ENSMUSP00000118007
Ensembl peptide - ENSMUSP00000115271
Ensembl peptide - ENSMUSP00000033671
NCBI entrez gene - 110651     See in Manteia.
MGI - MGI:104557
RefSeq - XM_017318355
RefSeq - NM_001346675
RefSeq - NM_148945
RefSeq - XM_006528686
RefSeq - XM_006528687
RefSeq - XM_006528688
RefSeq - XM_017318353
RefSeq - XM_017318354
RefSeq Peptide - NP_001333604
RefSeq Peptide - NP_683747
swissprot - B1AXP0
swissprot - B1AXN9
swissprot - B1AXN8
swissprot - F6UG16
swissprot - B1AXN7
swissprot - P18654
swissprot - B1AXN5
Ensembl - ENSMUSG00000031309
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RPS6KA3ENSGALG00000016406Gallus gallus
 P51812ENSG00000177189Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*ENSMUSG0000000364481
Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*ENSMUSG0000002380980
Rps6ka6 / ribosomal protein S6 kinase polypeptide 6 / Q9UK32* / ribosomal protein S6 kinase A6*ENSMUSG0000002566575
Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*ENSMUSG0000002118043
Q9Z2B9 / Rps6ka4 / ribosomal protein S6 kinase, polypeptide 4 / O75676* / ribosomal protein S6 kinase A4*ENSMUSG0000002495242
Q8BSK8 / Rps6kb1 / ribosomal protein S6 kinase, polypeptide 1 / P23443* / ribosomal protein S6 kinase B1*ENSMUSG0000002051630
Q9Z1M4 / Rps6kb2 / ribosomal protein S6 kinase, polypeptide 2 / Q9UBS0* / ribosomal protein S6 kinase B2*ENSMUSG0000002483029
Q8QZV4 / Stk32c / Serine/threonine-protein kinase 32C / Q86UX6* / serine/threonine kinase 32C*ENSMUSG0000001598117
Q8BGW6 / Stk32a / Serine/threonine-protein kinase 32A / Q8WU08* / serine/threonine kinase 32A*ENSMUSG0000003995417
Q9JJX8 / Stk32b / Serine/threonine-protein kinase 32B / Q9NY57* / serine/threonine kinase 32B*ENSMUSG0000002912317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
CREB phosphorylation through the activation of Ras
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

Allelic Composition: Rps6ka3tm1Ljg/Rps6ka3tm1Ljg
Genetic Background: involves: 129 * C57BL/6

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Egfrwa2/Egfr+,Rps6ka3tm1.1Kry/Y,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stk11tm2.1Arte/Stk11tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stk11tm2.1Arte/Stk11tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Egfrwa2/Egfr+,Rps6ka3tm1.1Kry/Y,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0003932 abnormal molar crown morphology "defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0004033 supernumerary teeth "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0004377 small frontal bone "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0004380 short frontal bone "reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0004418 small parietal bone "reduced size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0004610 small vertebrae "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

 MP:0011165 abnormal tooth root development "aberrant or incomplete formation of the part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [MGI:anna]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0011274 short excitatory postsynaptic current decay time 
Show

Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
Show

Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

 MP:0030029 wide cranial sutures "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0030388 large fontanelles "an abnormally increased size of one or more fontanelles for age-related norms, generally resulting from delayed or incomplete fontanelle closure" [HP:0000239, MGI:anna]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

 MP:0030536 abnormal diastema morphology "any anomaly of the space or gap between two adjacent teeth in the same dental arch; in rodents, the diastema is the toothless (edentulous) region that normally separates a continuously growing single incisor from a segment of three molars in each quadrant of the adult jaw; although tooth primordia develop in the rodent embryonic diastema, they undergo apoptosis and regress to ensure that this region remains tooth-free" [https://en.wikipedia.org/wiki/Diastema, PMID:16890158, PMID:24495023]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Y
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000001034 Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr