ENSMUSG00000024122


Mus musculus

Features
Gene ID: ENSMUSG00000024122
  
Biological name :Pdpk1
  
Synonyms : 3-phosphoinositide-dependent protein kinase 1 / Pdpk1 / Q9Z2A0
  
Possible biological names infered from orthology : O15530
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 24073680
Gene end: 24150924
  
Corresponding Affymetrix probe sets: 10448424 (MoGene1.0st)   10342214 (MoGene1.0st)   1415729_at (Mouse Genome 430 2.0 Array)   1416501_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121771
Ensembl peptide - ENSMUSP00000061942
Ensembl peptide - ENSMUSP00000099991
Ensembl peptide - ENSMUSP00000111066
Ensembl peptide - ENSMUSP00000111068
Ensembl peptide - ENSMUSP00000111070
Ensembl peptide - ENSMUSP00000115618
Ensembl peptide - ENSMUSP00000120548
NCBI entrez gene - 18607     See in Manteia.
MGI - MGI:1338068
RefSeq - XM_017317327
RefSeq - NM_001080773
RefSeq - NM_001286662
RefSeq - NM_011062
RefSeq - XM_017317320
RefSeq - XM_017317321
RefSeq - XM_017317322
RefSeq - XM_017317323
RefSeq - XM_017317324
RefSeq - XM_017317325
RefSeq - XM_017317326
RefSeq Peptide - NP_035192
RefSeq Peptide - NP_001074242
RefSeq Peptide - NP_001273591
swissprot - F2Z400
swissprot - F2Z4A5
swissprot - F2Z3X6
swissprot - Q3TRL2
swissprot - Q9Z2A0
swissprot - F2Z3V6
swissprot - F2Z3X9
swissprot - F2Z3Z9
Ensembl - ENSMUSG00000024122
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdpk1aENSDARG00000062304Danio rerio
 pdpk1bENSDARG00000018285Danio rerio
 PDPK1ENSGALG00000006418Gallus gallus
 PDPK1ENSG00000140992Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5SYL1 / BC030499 / Uncharacterized serine/threonine-protein kinase SgK494 / SGK494*ENSMUSG0000003759311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033931  PDK1-type, PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006972 hyperosmotic response IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0010518 positive regulation of phospholipase activity IEA
 biological_processGO:0010594 regulation of endothelial cell migration IMP
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043304 regulation of mast cell degranulation IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004676 3-phosphoinositide-dependent protein kinase activity IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016004 phospholipase activator activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043274 phospholipase binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Integrin alphaIIb beta3 signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
RHO GTPases activate PKNs
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Arg2tm1Weo/Arg2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Pdpk1tm2Ejm/Pdpk1tm2Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001214 skin hyperplasia "increased cell number in the skin; usually results in thick skin" [J:47225]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0001324 abnormal eye pigmentation "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arg2tm1Weo/Arg2+
Genetic Background: involves: C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arg2tm1Weo/Arg2+
Genetic Background: involves: C57BL/6J

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pdpk1tm1Bcol/Pdpk1tm1Bcol
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Arg2tm1Weo/Arg2+
Genetic Background: involves: C57BL/6J

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S4/SvJae

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Whb/Foxo1+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm2Mrc/Hoxa1+,Hoxa2tm1Mrc/Hoxa2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Arg2tm1Weo/Arg2+
Genetic Background: involves: C57BL/6J

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1.1Daca/Pdpk1tm1.1Daca
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Foxo1*)Jcbr/Gt(ROSA)26Sor+,Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Foxo1tm1Whb/Foxo1+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0002706 abnormal kidney size "anomalous physical bulk one or both of the organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxo1tm1Whb/Foxo1+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0003874 absent branchial arches "missing the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm2Ejm/Pdpk1tm2Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0004559 small allantois "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0004972 abnormal regulatory T cell number "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdpk1tm1.1Daca/Pdpk1tm1.1Daca
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1Mlw,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1.1Daca/Pdpk1tm1.1Daca
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1Mlw,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1Mlw,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxo1tm1Whb/Foxo1+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Whb/Foxo1+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005667 abnormal circulating leptin level "aberrant blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0008036 abnormal NK T cell morphology "any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1Mlw,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Pdpk1tm1.1Daca/Pdpk1tm1.1Daca
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1Mlw,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008041 absent NK T cells "absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1Mlw,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008130 abnormal pituitary intermediate lobe "any structural anomaly of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0008324 abnormal melanotroph morphology "any structural anomaly of a cell of the intermediate pituitary that produces melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC)" [CL:0000440, MESH:A06.407.747.671.500]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008341 decreased corticotroph cell number "reduced number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Foxo1*)Jcbr/Gt(ROSA)26Sor+,Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008460 absent dorsal root ganglion "absence of the groups of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008716 lung non-small cell carcinoma "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300]
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Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0009169 pancreatic islet hypoplasia "underdevelopment or decreased size of the clusters of hormone-producing cells that are scattered throughout the pancreas, usually due an decreased number of cells" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Pdpk1tm1Dral/Pdpk1tm1Dral
Genetic Background: B6.129P2-Pdpk1tm1Dral

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0010500 myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: BALB/c

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pdpk1tm1Bcol/Pdpk1tm1Bcol
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1tm1Dlo,Casp9tm1Flv/?
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pdpk1tm2Ejm/Pdpk1tm2Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pdpk1tm1.1Daca/Pdpk1tm1.1Daca
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

Allelic Composition: Pdpk1tm2Ejm/Pdpk1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011156 abnormal hypodermis fat layer morphology "any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage" [ISBN:0-683-40008-8]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011259 abnormal cephalic neural fold morphology "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0011388 absent heart "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0012081 absent heart tube "absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [MGI:anna]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pdpk1tm2Ejm/Pdpk1tm2Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0012176 abnormal head development "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0012182 abnormal presomitic mesoderm morphology "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0012745 abnormal neural crest cell physiology "any functional anomaly in the complex process by which multipotent neural crest progenitors acquire migratory and invasive properties, emigrate from the dorsal aspect of the neural tube, migrate along distinct pathways, and differentiate into diverse cell types" [MGI:anna]
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Allelic Composition: Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
Genetic Background: involves: BALB/c

 MP:0013344 increased pituitary gland apoptosis "increase in the number of any cells of the pituitary gland undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0013346 increased melanotroph apoptosis "increase in the number of cells of the intermediate pituitary that produce melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC) undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0013347 increased corticotroph apoptosis "increase in the number of anterior pituitary ACTH-producing basophilic cells undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026778 Prkcq / Q02111 / protein kinase C, theta / Q04759*  / reaction
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / reaction
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / reaction / complex
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / reaction / complex
 ENSMUSG00000032688 Malt1 / Q2TBA3 / Mucosa-associated lymphoid tissue lymphoma translocation / Q9UDY8* / MALT1 paracaspase*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000057672 Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*  / complex / reaction
 ENSMUSG00000052889 Prkcb / P68404 / protein kinase C, beta / P05771*  / reaction
 ENSMUSG00000004056 Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*  / reaction
 ENSMUSG00000029053 Prkcz / Q02956 / protein kinase C, zeta / Q05513*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / reaction
 ENSMUSG00000021948 Prkcd / P28867 / protein kinase C, delta / Q05655*  / reaction
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / complex / reaction
 ENSMUSG00000019970 Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*  / reaction
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction / complex
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / reaction
 ENSMUSG00000036526 Card11 / Q8CIS0 / Caspase recruitment domain-containing protein 11 / Q9BXL7* / caspase recruitment domain family member 11*  / complex / reaction
 ENSMUSG00000003644 P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*  / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000031309 P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*  / reaction
 ENSMUSG00000050965 Prkca / protein kinase C, alpha / P17252*  / reaction
 ENSMUSG00000004591 Pkn2 / Q8BWW9 / Serine/threonine-protein kinase N2 / Q16513* / protein kinase N2*  / complex / reaction
 ENSMUSG00000023809 Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*  / reaction






 

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