ENSMUSG00000057672


Mus musculus

Features
Gene ID: ENSMUSG00000057672
  
Biological name :Pkn1
  
Synonyms : P70268 / Pkn1 / Serine/threonine-protein kinase N1
  
Possible biological names infered from orthology : protein kinase N1 / Q16512
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 83666536
Gene end: 83699179
  
Corresponding Affymetrix probe sets: 10580010 (MoGene1.0st)   1436542_at (Mouse Genome 430 2.0 Array)   1436851_at (Mouse Genome 430 2.0 Array)   1459231_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116235
Ensembl peptide - ENSMUSP00000005616
Ensembl peptide - ENSMUSP00000115054
NCBI entrez gene - 320795     See in Manteia.
MGI - MGI:108022
RefSeq - NM_001199593
RefSeq - NM_177262
RefSeq Peptide - NP_001186522
RefSeq Peptide - NP_796236
swissprot - D6RH37
swissprot - P70268
Ensembl - ENSMUSG00000057672
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkn1aENSDARG00000060184Danio rerio
 pkn1bENSDARG00000062748Danio rerio
 PKN1ENSG00000123143Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pkn2 / Q8BWW9 / Serine/threonine-protein kinase N2 / Q16513* / protein kinase N2*ENSMUSG0000000459161
Pkn3 / Q8K045 / Serine/threonine-protein kinase N3 / Q6P5Z2* / protein kinase N3*ENSMUSG0000002678547


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011072  HR1 rho-binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR035892  C2 domain superfamily
 IPR036274  HR1 repeat superfamily
 IPR037313  Serine/threonine-protein kinase N, first HR1 domain
 IPR037317  Serine/threonine-protein kinase N1, second HR1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0001783 B cell apoptotic process IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0002634 regulation of germinal center formation IMP
 biological_processGO:0002637 regulation of immunoglobulin production IMP
 biological_processGO:0003014 renal system process IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0006972 hyperosmotic response IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010631 epithelial cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 biological_processGO:0035407 histone H3-T11 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0048536 spleen development IMP
 biological_processGO:2000145 regulation of cell motility IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0032154 cleavage furrow ISO
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0035402 histone kinase activity (H3-T11 specific) IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA
 molecular_functionGO:0050681 androgen receptor binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Pkn1tm1Ajmc/Pkn1tm1Ajmc,Pkn3tm1Ajmc/Pkn3tm1Ajmc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NTac

Allelic Composition: Pkn1tm1Ajmc/Pkn1tm1Ajmc,Pkn2tm1a(KOMP)Wtsi/Pkn2+,Pkn3tm1Ajmc/Pkn3tm1Ajmc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * C57BL/6NTac

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0010675 decreased activation-induced B cell apoptosis "decreased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death" [PMID:11032170]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005886 Ncoa2 / Q61026 / Nuclear receptor coactivator 2 / Q15596*  / complex / reaction
 ENSMUSG00000036940 Kdm1a / Q6ZQ88 / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341* / lysine demethylase 1A*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction / complex
 ENSMUSG00000037166 Q91VC7 / Ppp1r14a / Protein phosphatase 1 regulatory subunit 14A / Q96A00* / protein phosphatase 1 regulatory inhibitor subunit 14A*  / reaction
 ENSMUSG00000044201 Cdc25c / P48967 / cell division cycle 25C / P30307*  / reaction / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000028397 Kdm4c / Q8VCD7 / Mus musculus lysine (K)-specific demethylase 4C (Kdm4c), transcript variant 3, mRNA. / Q9H3R0* / lysine demethylase 4C*  / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction / complex
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr