ENSMUSG00000054364


Mus musculus

Features
Gene ID: ENSMUSG00000054364
  
Biological name :Rhob
  
Synonyms : P62746 / ras homolog family member B / Rhob
  
Possible biological names infered from orthology : P62745
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 8497661
Gene end: 8500009
  
Corresponding Affymetrix probe sets: 10399360 (MoGene1.0st)   1449110_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067013
NCBI entrez gene - 11852     See in Manteia.
MGI - MGI:107949
RefSeq - NM_007483
RefSeq Peptide - NP_031509
swissprot - P62746
swissprot - Q4FJM5
Ensembl - ENSMUSG00000054364
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RHOBENSGALG00000016485Gallus gallus
 RHOBENSG00000143878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*ENSMUSG0000000223383
Rhoa / Q9QUI0 / ras homolog family member A / P61586*ENSMUSG0000000781583
4930544G11Rik / RIKEN cDNA 4930544G11 geneENSMUSG0000003646374
Rhod / P97348 / ras homolog family member D / O00212*ENSMUSG0000004184549
Rnd3 / P61588 / Rho-related GTP-binding protein RhoE / P61587* / Rho family GTPase 3*ENSMUSG0000001714447
Rhof / Q8BYP3 / ras homolog family member F (in filopodia) / Q9HBH0* / ras homolog family member F, filopodia associated*ENSMUSG0000002944945
Rnd2 / Q9QYM5 / Rho family GTPase 2 / P52198*ENSMUSG0000000131343
Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*ENSMUSG0000005485540


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006886 intracellular protein transport IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045786 negative regulation of cell cycle IMP
 biological_processGO:0061154 endothelial tube morphogenesis IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0032154 cleavage furrow ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0019003 GDP binding IDA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca,Tfrctm1Nca/Tfrc+
Genetic Background: Not Specified

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca,Tfrctm1Nca/Tfrc+
Genetic Background: Not Specified

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca,Tfrctm1Nca/Tfrc+
Genetic Background: Not Specified

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca,Tfrctm1Nca/Tfrc+
Genetic Background: Not Specified

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca,Tfrctm1Nca/Tfrc+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / reaction
 ENSMUSG00000057672 Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*  / complex / reaction
 ENSMUSG00000020580 Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction / complex
 ENSMUSG00000021451 O09126 / Sema4d / Semaphorin-4D / Q92854*  / reaction
 ENSMUSG00000004591 Pkn2 / Q8BWW9 / Serine/threonine-protein kinase N2 / Q16513* / protein kinase N2*  / complex / reaction
 ENSMUSG00000041977 Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*  / reaction
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction / complex
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction
 ENSMUSG00000024290 Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000034930 Rtkn / Q8C6B2 / Rhotekin / Q9BST9*  / complex / reaction
 ENSMUSG00000038943 Prc1 / Q99K43 / protein regulator of cytokinesis 1 / O43663*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / complex / reaction
 ENSMUSG00000022021 3 / Diaph3 / Q9Z207 / Q9NSV4* / diaphanous related formin 3*  / reaction / complex
 ENSMUSG00000041498 Kif14 / L0N7N1 / Kinesin-like protein KIF14 / Q15058* / kinesin family member 14*  / reaction / complex
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / reaction
 ENSMUSG00000059495 Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*  / reaction






 

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