ENSMUSG00000022021


Mus musculus

Features
Gene ID: ENSMUSG00000022021
  
Biological name :Diaph3
  
Synonyms : 3 / Diaph3 / Q9Z207
  
Possible biological names infered from orthology : diaphanous related formin 3 / Q9NSV4
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E1
Gene start: 86655367
Gene end: 87141235
  
Corresponding Affymetrix probe sets: 10421877 (MoGene1.0st)   1422944_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022599
Ensembl peptide - ENSMUSP00000129420
Ensembl peptide - ENSMUSP00000153711
Ensembl peptide - ENSMUSP00000154037
Ensembl peptide - ENSMUSP00000154692
NCBI entrez gene - 56419     See in Manteia.
MGI - MGI:1927222
RefSeq - XM_006519312
RefSeq - XM_011245123
RefSeq - NM_019670
RefSeq Peptide - NP_062644
swissprot - Q3UVP0
swissprot - F8WIG5
swissprot - Q9Z207
Ensembl - ENSMUSG00000022021
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 diaph3ENSDARG00000090785Danio rerio
 DIAPH3ENSGALG00000016937Gallus gallus
 DIAPH3ENSG00000139734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
2 / Diaph2 / O70566 / O60879* / diaphanous related formin 2*ENSMUSG0000003448051
1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*ENSMUSG0000002445647
Daam1 / Q8BPM0 / Disheveled-associated activator of morphosis 1 / Q9Y4D1* / dishevelled associated activator of morphogenesis 1*ENSMUSG0000003457423
Daam2 / Q80U19 / Disheveled-associated activator of morphosis 2 / Q86T65* / dishevelled associated activator of morphogenesis 2*ENSMUSG0000004026023
Inf2 / inverted formin, FH2 and WH2 domain containing / Q27J81*ENSMUSG0000003767921
Fmnl3 / Q6ZPF4 / Formin-like protein 3 / Q8IVF7* / formin like 3*ENSMUSG0000002300820
Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*ENSMUSG0000005580520
Fmnl2 / A2APV2 / Formin-like protein 2 / Q96PY5* / formin like 2*ENSMUSG0000003605320
Fhdc1 / Q3ULZ2 / FH2 domain-containing protein 1 / Q9C0D6* / FH2 domain containing 1*ENSMUSG0000004184212


Protein motifs (from Interpro)
Interpro ID Name
 IPR010465  DRF autoregulatory
 IPR010472  Formin, FH3 domain
 IPR010473  Formin, GTPase-binding domain
 IPR011989  Armadillo-like helical
 IPR014767  Diaphanous autoregulatory (DAD) domain
 IPR014768  Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
 IPR015425  Formin, FH2 domain
 IPR016024  Armadillo-type fold
 IPR027654  Formin, protein diaphanous homologue 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016043 cellular component organization IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

 MP:0011179 decreased erythroblast number "reduced number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0012397 abnormal nucleated erythrocyte cell number "abnormal numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MPD:Molly]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022021 3 / Diaph3 / Q9Z207 / Q9NSV4* / diaphanous related formin 3*  / complex
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr