ENSMUSG00000055805


Mus musculus

Features
Gene ID: ENSMUSG00000055805
  
Biological name :Fmnl1
  
Synonyms : Fmnl1 / Formin-like protein 1 / Q9JL26
  
Possible biological names infered from orthology : formin like 1 / O95466
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 103171107
Gene end: 103198901
  
Corresponding Affymetrix probe sets: 10381708 (MoGene1.0st)   1450212_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151439
Ensembl peptide - ENSMUSP00000046296
Ensembl peptide - ENSMUSP00000102642
Ensembl peptide - ENSMUSP00000133299
NCBI entrez gene - 57778     See in Manteia.
MGI - MGI:1888994
RefSeq - XM_006533845
RefSeq - XM_006533839
RefSeq - XM_006533840
RefSeq - XM_006533841
RefSeq - XM_006533842
RefSeq - XM_006533843
RefSeq - XM_006533844
RefSeq - NM_001077698
RefSeq - NM_019679
RefSeq - XM_006533837
RefSeq - XM_006533838
RefSeq Peptide - NP_001071166
RefSeq Peptide - NP_062653
swissprot - G3UWI1
swissprot - A2AB60
swissprot - Q9JL26
swissprot - A0A1W2P6X3
Ensembl - ENSMUSG00000055805
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01055365.1ENSDARG00000104263Danio rerio
 fmnl1aENSDARG00000055713Danio rerio
 ENSGALG00000032155Gallus gallus
 ENSGALG00000032658Gallus gallus
 FMNL1ENSG00000184922Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fmnl2 / A2APV2 / Formin-like protein 2 / Q96PY5* / formin like 2*ENSMUSG0000003605357
Fmnl3 / Q6ZPF4 / Formin-like protein 3 / Q8IVF7* / formin like 3*ENSMUSG0000002300854
Daam1 / Q8BPM0 / Disheveled-associated activator of morphosis 1 / Q9Y4D1* / dishevelled associated activator of morphogenesis 1*ENSMUSG0000003457424
Daam2 / Q80U19 / Disheveled-associated activator of morphosis 2 / Q86T65* / dishevelled associated activator of morphogenesis 2*ENSMUSG0000004026024
1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*ENSMUSG0000002445621
3 / Diaph3 / Q9Z207 / Q9NSV4* / diaphanous related formin 3*ENSMUSG0000002202121
2 / Diaph2 / O70566 / O60879* / diaphanous related formin 2*ENSMUSG0000003448020
Inf2 / inverted formin, FH2 and WH2 domain containing / Q27J81*ENSMUSG0000003767919
Fhdc1 / Q3ULZ2 / FH2 domain-containing protein 1 / Q9C0D6* / FH2 domain containing 1*ENSMUSG0000004184212


Protein motifs (from Interpro)
Interpro ID Name
 IPR010472  Formin, FH3 domain
 IPR010473  Formin, GTPase-binding domain
 IPR011989  Armadillo-like helical
 IPR014767  Diaphanous autoregulatory (DAD) domain
 IPR014768  Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
 IPR015425  Formin, FH2 domain
 IPR016024  Armadillo-type fold
 IPR027657  Formin-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006929 substrate-dependent cell migration IMP
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0009987 cellular process IMP
 biological_processGO:0016043 cellular component organization IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0051014 actin filament severing IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005522 profilin binding IDA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IDA
 molecular_functionGO:0051015 actin filament binding IDA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mfsd2btm1a(KOMP)Wtsi/Mfsd2btm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mfsd2btm1a(KOMP)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018293 Pfn1 / P62962 / profilin 1 / P07737*  / complex / reaction
 ENSMUSG00000055805 Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*  / complex
 ENSMUSG00000006699 Cdc42 / P60766 / Cell division control   / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000026425 Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...  / reaction / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex
 ENSMUSG00000027805 Pfn2 / Q9JJV2 / Profilin-2 / P35080*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex






 

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