ENSMUSG00000006699


Mus musculus

Features
Gene ID: ENSMUSG00000006699
  
Biological name :Cdc42
  
Synonyms : Cdc42 / Cell division control / P60766
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 137319696
Gene end: 137357720
  
Corresponding Affymetrix probe sets: 10517559 (MoGene1.0st)   10344414 (MoGene1.0st)   1415724_a_at (Mouse Genome 430 2.0 Array)   1435807_at (Mouse Genome 430 2.0 Array)   1449574_a_at (Mouse Genome 430 2.0 Array)   1460708_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030417
Ensembl peptide - ENSMUSP00000054634
NCBI entrez gene - 12540     See in Manteia.
MGI - MGI:106211
RefSeq - NM_001243769
RefSeq - NM_009861
RefSeq Peptide - NP_001230698
RefSeq Peptide - NP_033991
swissprot - P60766
Ensembl - ENSMUSG00000006699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc42ENSDARG00000044573Danio rerio
 CDC42ENSGALG00000004796Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*ENSMUSG0000000184771
Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*ENSMUSG0000003322069
Rac3 / P60764 / RAS-related C3 botulinum substrate 3 / P60763* / Rac family small GTPase 3*ENSMUSG0000001801269
Rhoq / Q8R527 / Rho-related GTP-binding protein RhoQ / P17081* / ras homolog family member Q*ENSMUSG0000002414366
Rhoj / Q9ER71 / ras homolog family member J / Q9H4E5*ENSMUSG0000004676862
Rhog / P84096 / ras homolog family member G / P84095*ENSMUSG0000007398261
Rhou / Q9EQT3 / Rho-related GTP-binding protein RhoU / Q7L0Q8* / ras homolog family member U*ENSMUSG0000003996058
Rhov / Q8VDU1 / Rho-related GTP-binding protein RhoV / Q96L33* / ras homolog family member V*ENSMUSG0000003422653
Q9DAK3 / Rhobtb1 / Rho-related BTB domain-containing protein 1 / O94844* / Rho related BTB domain containing 1*ENSMUSG0000001994440
Q91V93 / Rhobtb2 / Rho-related BTB domain-containing protein 2 / Q9BYZ6* / Rho related BTB domain containing 2*ENSMUSG0000002207540


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0003161 cardiac conduction system development IGI
 biological_processGO:0003334 keratinocyte development IMP
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0006911 phagocytosis, engulfment ISS
 biological_processGO:0007015 actin filament organization ISS
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0007088 regulation of mitotic nuclear division IMP
 biological_processGO:0007097 nuclear migration IMP
 biological_processGO:0007163 establishment or maintenance of cell polarity TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0031424 keratinization IMP
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032467 positive regulation of cytokinesis ISS
 biological_processGO:0032488 Cdc42 protein signal transduction IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0034329 cell junction assembly ISS
 biological_processGO:0034332 adherens junction organization IMP
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0035088 establishment or maintenance of apical/basal cell polarity IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0036336 dendritic cell migration IGI
 biological_processGO:0042176 regulation of protein catabolic process IMP
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043497 regulation of protein heterodimerization activity IDA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IMP
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity ISS
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045859 regulation of protein kinase activity IMP
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046847 filopodium assembly IDA
 biological_processGO:0048664 neuron fate determination IMP
 biological_processGO:0048730 epidermis morphogenesis IMP
 biological_processGO:0051017 actin filament bundle assembly IMP
 biological_processGO:0051246 regulation of protein metabolic process IMP
 biological_processGO:0051489 regulation of filopodium assembly ISS
 biological_processGO:0051491 positive regulation of filopodium assembly IMP
 biological_processGO:0051647 nucleus localization IMP
 biological_processGO:0051683 establishment of Golgi localization IEA
 biological_processGO:0051835 positive regulation of synapse structural plasticity IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore ISS
 biological_processGO:0060047 heart contraction IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
 biological_processGO:0060661 submandibular salivary gland formation IEA
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IMP
 biological_processGO:0060789 hair follicle placode formation IMP
 biological_processGO:0060997 dendritic spine morphogenesis IMP
 biological_processGO:0071338 positive regulation of hair follicle cell proliferation IMP
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0072384 organelle transport along microtubule IEA
 biological_processGO:0090135 actin filament branching IEA
 biological_processGO:0090136 epithelial cell-cell adhesion IMP
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 biological_processGO:0098609 cell-cell adhesion TAS
 biological_processGO:0099563 modification of synaptic structure IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading ISS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000322 storage vacuole IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030496 midbody ISS
 cellular_componentGO:0031256 leading edge membrane IDA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0051233 spindle midzone ISS
 cellular_componentGO:0071944 cell periphery IDA
 cellular_componentGO:0072686 mitotic spindle ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030742 GTP-dependent protein binding IPI
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0051022 Rho GDP-dissociation inhibitor binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000388 absent inner root sheath "missing epidermally derived layer surrounding the hair follicle; innermost of two layers" [J:65047]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000440 domed skull 
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Vipr1tm1Dgen/Vipr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vipr1tm1Dgen/Vipr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vipr1tm1Dgen/Vipr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vipr1tm1Dgen/Vipr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0000524 reduced renal tubule number "fewer loops of Henle and collecting ducts" [J:40203]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000794 abnormal parietal lobe morphology "malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000935 abnormal folding of telencephalic vesicles "malformation of the stereotypic invaginations forming the paired diverticula of the telencephalon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001247 dermal cysts "abnormal membranous sacs appearing in the dermis" [J:53379]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Vipr1tm1Dgen/Vipr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vipr1tm1Dgen/Vipr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Bmi1tm1(cre/ERT)Mrc/Bmi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002958 aqueductal stenosis "the most common form of obstructive hydrocephaly and results from narrowing of the aqueduct of Sylvius, which connects the third and fourth ventricles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0003624 anuria "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgd4tm1Ics/Fgd4tm1Ics,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0003925 abnormal cellular glucose import "anomaly in the ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004639 fused metacarpal bones "improper union of one or more of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005034 abnormal anus morphology "structural anomaly of the lower opening of the digestive tract" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Unc93b1tm1.1Kmiy/Unc93b1tm1.1Kmiy
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cdc42tm1.1Yizh/Cdc42+
Genetic Background: Not Specified

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008800 increased small intestinal crypt cell apoptosis "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009688 abnormal spinal cord central canal morphology "any structural anomaly of the ependyma-lined lumen of the spinal cord that is filled with cerebrospinal fluid; it is patent with the ventricular system of the brain and frequently becomes occluded in aging adults" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010152 abnormal brain ependyma morphology "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

Allelic Composition: Cdc42tm1Brak/Cdc42+,Rab8atm1.1Aha/Rab8a+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0010156 abnormal small intestinal crypt cell physiology "altered function of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010686 abnormal hair follicle matrix region morphology "any structural anomaly of the bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath" [PMID:19211055]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010802 abnormal intestinal enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0011057 absent brain ependyma motile cilia "absence of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Lamc1Gt(Ex183)Byg/Lamc1Gt(Ex183)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdc42tm1Fwa/Cdc42tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011184 absent embryonic epiblast "absence of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
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Allelic Composition: Cdc42tm1Fwa/Cdc42tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Cdc42tm1.1Rac/Cdc42tm1.1Rac,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Cdc42tm1.1Yizh/Cdc42+,Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0014076 absent Paneth cells "absence or loss of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0030393 delayed fontanelle closure "late onset of closure of one or more of the membranous intervals at the margins of cranial bones" [MGI:anna]
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Allelic Composition: Mre11atm1.1Rchd/Mre11atm1.1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055805 Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*  / reaction / complex
 ENSMUSG00000031165 Was / P70315 / Wiskott-Aldrich syndrome / P42768*  / complex / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction / complex
 ENSMUSG00000022957 Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*  / reaction / complex
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / reaction / complex
 ENSMUSG00000011958 Bnip2 / O54940 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 / Q12982* / BCL2 interacting protein 2*  / complex / reaction
 ENSMUSG00000033022 Cdo1 / P60334 / Cysteine dioxygenase type 1 / Q16878*  / reaction / complex






 

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